Cancer Biology

oncoprotein signaling networks

• Email: hema.adhikari@wustl.edu

Identification of new targets to improve tumor radiation effectiveness and to protect normal tissues such as the heart from radiation injury

• Email: acbergom@wustl.edu

The interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis

• Email: bolton@wustl.edu

Tyrosine Kinase Signaling in Breast Cancer

• Email: rbose@dom.wustl.edu

pediatric, glioma, obesity, neurofibromatosis, neurodevelopment

• Email: nbrossier@wustl.edu

Immunotherapy, brain tumor, spinal cord tumor, high grade gliomas

• Email: jcampian@dom.wustl.edu

genetic determinants and pathogenic mechanisms of urogenital diseases with the goal of improving diagnostic and therapeutic strategies targeting these diseases

• Email: fchen@wustl.edu

Understanding T cells and immunoregulatory networks in GvHD and GvL for the treatment of hematopoietic malignancies

• Email: jchoi25@wustl.edu

neurologic complications of cancer and its treatment

• Email: mai@wustl.edu

Cancer Proteogenomics and Cancer Models

• Email: lding@wustl.edu

We use both mouse models and patient samples of acute myloid leukemia to understand leukemogenesis and to identify novel therapeutic targets.

• Email: ferrarof@wustl.edu

AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

• Email: alirezag@wustl.edu

Metabolism of cancer, targeting tumor metabolism by blocking metabolic pathways

• Email: matthewlgoodwin@wustl.edu

identify factors within DNA damage response signaling pathways that represent therapeutic vulnerabilities in order to develop new treatment options for children with cancer

• Email: abby.green@wustl.edu

Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics

• Email: ericg@wustl.edu

cancer, metabolism, imaging, sex differences, glioblastoma

• Email: ippolitoj@wustl.edu

• Twitter

Hematopoietic stem cells, Multipotent progenitor, Cell fate decision, Lineage specification

• Email: yoonakang@wustl.edu

Cancer, Targeted therapy, Antibodies, Cell signaling, antibody-drug conjugates, drug resistance

• Email: vkapoor@wustl.edu

DNA damage response and how to apply new discoveries to the treatment of cancer

• Email: krais@wustl.edu

cancer genomics, leukemia, oncogene

• Email: timley@wustl.edu

Epigenetics, prostate cancer, transcriptomics, small molecule therapeutics, radioresistance, DNA damage signaling, and tumor-immune dynamics

• Email: kiranm@wustl.edu

proteomics, functional genomics, lung cancer, signal transduction, WNT, oxidative stress

• Email: bmajor@wustl.edu

prognosis and response to radiation therapy, therapeutic targets for cervical and anal cancers

• Email: smarkovina@wustl.edu

immune regulation of graft-versus-host disease (GVHD), a debilitating and potentially fatal complication of hematopoietic stem cell transplantation (HSCT)

• Email: mmmavers@wustl.edu

Epigenetics, Chromatin, Genomics, Gene Regulation, Cell fate, Transcription Factors

• Email: meers@wustl.edu

spinal deformity, spinal oncology, improving surgical safety, efficacy, and efficiency

• Email: cmolina@wustl.edu

Dendritic cells control adaptive immune responses

• Email: kmurphy@wustl.edu

Cartilage MRI, sustainability in Radiology, image-guided ablation of musculoskeletal tumors, musculoskeletal interventional radiology

• Email: northrupb@wustl.edu

identifying determinant protein domains governing voltage sensing and gate opening mechanisms of the cardiac IKs channel, which is a pathological determinant of the high mortality “Long QT Syndrome”

• Email: hpan@wustl.edu

To understand the metabolic crosstalk between cells and tissues in disease models such as cancer by using isotopes and metabolomics

• Email: gjpattij@wustl.edu

Role of Senescent T cells in tumor and neurodegeneration; tumor-associated regulatory T cells (Tregs) in suppression of anti-tumor immunity, Toll-like receptor (TLR) ligands and other immunomodulators; metabolic and epigenetic reprogramming of T cells for immunotherapy

• Email: pengg@wustl.edu

Clinical and translational theranostics

• Email: pvikas@wustl.edu

Molecular imaging tools to understand tumor biology and response to therapies

• Email: ribeiropereirap@wustl.edu

tumor biology, signal transduction, stem cells, neural development, sexual dimorphism, circadaian rhythm, chemokines, cAMP

• Email: Rubin_J@wustl.edu

Gynecologic cancers, thyroid cancer, molecular imaging

• Email: jschwarz@wustl.edu

targeting cancer-specific abnormalities, biology of cancer-relevant cellular proteins, breast cancer

• Email: shao.j@wustl.edu

Epigenetics, stem cell radiation response, chromatin and DNA damage response, apoptosis, DNA repair, post-translational histone modifications, oncogenesis.

• Email: sharma@wustl.edu

Antigen-4 (VLA-4) targeted PET radiopharmaceuticals, multiple myeloma, hematopoietic progenitor cells (HPCs), PET, MRI and Optical imaging techniques

• Email: mshokeen@wustl.edu

Long non-coding RNAs and RNA modifications in cancer metastasis and relapse

• Email: silvajm@wustl.edu

pathogenesis of glioblastoma, tumor-mediated immune suppression, nanotechnologies

• Email: stegh@wustl.edu

cancer metastasis; tumor microenvironment, cancer immunology, CRISPR screen, quantitative biology

• Email: ruit@wustl.edu

skin microbiome, skinomics, metagenomics, host-microbial genetics

• Email: uberoi@wustl.edu

The Verma lab studies the causes and consequences of DNA damage in cancers

• Email: vermap@wustl.edu

Tumor Immunology, Neoantigens, Immunotherapy

• Email: jward2@wustl.edu

pancreatic cancer, immunotherapy, myeloid cells, tumor microenvironment, CRISPR screening

• Email: wattenberg@wustl.edu

Pancreatic cancer, immunotherapy, myeloid cells, CRISPR screening, translational research

• Email: wattenberg@wustl.edu

Cancer, DNA damage response, RNA surveillance, cell cycle, chromatin, laser micro-irradiation, Xenopus egg extracts, imaging, genetically-encoded reporters

• Email: zyou@wustl.edu

mechanisms that influence arterial collateral formation and peripheral arterial atheroprogression in the setting of diabetes

• Email: zayedm@wustl.edu