Molecular Cell Biology

biophysics, cancer, imaging, mathematical modeling, neurobiology

• Email: ackerman@wustl.edu

Isolation and characterization of cancer-related genes

• Email: aft@wustl.edu

Function and modulation of transmitter-gated ion channels

• Email: akk@wustl.edu

Understanding the endogenous opioid systems to defeat addiction, ameliorate affective disorders, and relieve chronic pain.

• Email: al-hasanir@wustl.edu

Uncovering novel regulators of glycolytic and mitochondrial metabolism at the synapse and their role in the pathology of Alzheimer’s disease

• Email: ghazaleh@wustl.edu

We investigate the mechanisms of neoplasia and metastasis, and develop targeted drug-delivery systems for cancer treatment.

• Email: aazab@wustl.edu

Cell and molecular biology of the ocular lens

• Email: bassnett@vision.wustl.edu

Understanding the importance of telomerase in human stem and progenitor cell function and regulation

• Email: lbatista@wustl.edu

My lab investigates the signals that regulate early B cell development. Specifically, we are interested in how cellular responses activated by double-strand DNA breaks integrate with normal development processes.

• Email: bednarski_j@wustl.edu

Identification of new targets to improve tumor radiation effectiveness and to protect normal tissues such as the heart from radiation injury

• Email: acbergom@wustl.edu

Novel mechanisms of cardiovascular disease in human and mouse models with insulin resistance and type 2 DM

• Email: cbernal@im.wustl.edu

G protein-coupled receptor signaling in physiology and disease

• Email: kblumer@wustl.edu

Tyrosine Kinase Signaling in Breast Cancer

• Email: rbose@dom.wustl.edu

Cell biology of developing nerve and muscle cells

• Email: bridgmap@wustl.edu

Cell and molecular mechanisms of airway epithelial cell differentiation and cilia biogenesis

• Email: brodys@wustl.edu

Obesity, diabetes, skeletal muscle, metabolism, cellular stress response

• Email: rbrookheart@wustl.edu

Regulation of coagulation, hemostasis

• Email: gbroze@wustl.edu

Molecular Biology of DNA replication and damage response in yeast and human

• Email: burgers@wustl.edu

Cellular, Molecular and Epigenetic control of axon regeneration

• Email: cavalli@wustl.edu

Hematopoietic stem cells, Leukemia stem cells, Epigenetic modifications

• Email: gchallen@wustl.edu

pathogenesis of neurodegenerative diseases, inflammation, CNS immune responses, myeloid cell responses

• Email: achaney@wustl.edu

molecular mechanisms of opioid receptor signaling, nanobodies, X-ray, Cryo-EM, opioid receptor signaling

• Email: taoche@wustl.edu

Combines biology, engineering, and medicine to develop ultrasound techniques for noninvasive, targeted, and personalized cancer treatment

• Email: hongchen@wustl.edu

Understanding the function of neuromodulators and sleep through the spatiotemporal dynamics of molecular signals

• Email: yaochen@wustl.edu

I am interested in the structure and function of neuronal ligand-gated ion channels, and the mechanism of channel modulation by endogenous lipids or exogenous drugs such as general anesthetics.

• Email: wayland.cheng@wustl.edu

Understanding epigenetic and genetic mechanisms governing the cancer stem cell state

• Email: mchheda@dom.wustl.edu

Understanding T cells and immunoregulatory networks in GvHD and GvL for the treatment of hematopoietic malignancies

• Email: jchoi25@wustl.edu

Cell fate, transcription factors, hematopoiesis, vascular, development, regeneration, stem cells, angiogenesis, tumor

• Email: kchoi@pathology.wustl.edu

Idiopathic pulmonary fibrosis (IPF), metabolic networks, targetable mechanisms driving fibroblast function and fibrosis

• Email: malay@wustl.edu

Bone biology, cell adhesion, signal transduction, gap junctions, cadherin

• Email: rcivitel@dom.wustl.edu

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lung vascular biology, cardiopulmonary diseases, single-cell RNA-sequencing, spatial transcriptomics

• Email: z.dai@wustl.edu

Gene expression, RNA, cancer, mRNA editing, mRNA stability

• Email: nod@wustl.edu

Understanding the molecular and cellular mechanisms of protein aggregation and neurodegeneration in Parkinson disease and dementia with Lewy bodies

• Email: albert.a.davis@wustl.edu

Cancer metabolism, fasting liver metabolism and caloric restriction mechanisms in diabetes and obesity, mechanistic action of chemotherapy, mitochondrial metabolism, cell signaling

• Email: bdebosch@wustl.edu

Innate immunity, immunodeficiency, inflammation, hematology

• Email: dinauer_m@wustl.edu

enteric virus infection, innate immune response, intestinal inflammatory signaling

• Email: siyuan.ding@wustl.edu

Lysosomes, Ischemia-reperfusion, cell death, autophagy, transcriptional regulation, metabolism

• Email: adiwan@wustl.edu

Cytoskeleton, microtubules, molecular motors, optical molecular imaging, plant biology

• Email: ramdixit@wustl.edu

Biochemistry, miRNA, RNA, Ribosome, translation, gene expression, translational control, cancer, malaria

• Email: sergej.djuranovic@wustl.edu

Gene regulation, host-pathogen interactions, biochemistry, microbial pathogenesis, pathogenic fungi, yeast, glycobiology, biosynthetic pathways, blood-brain barrier, host response

• Email: doering@wustl.edu

Signal transduction, centrioles, cilia, human ciliopathies

• Email: dutcher@wustl.edu

Metabolism, epigenetics, alcohol, addiction, neurodegeneration, Alzheimer’s

• Email: gabor@wustl.edu

Analysis of maternal virome and antiviral antibodies to determine the role of viral exposure in the causation of congenital heart disease.

• Email: eghtesady670@wustl.edu

Women’s health, potassium channels, uterine, muscle excitability, pregnancy

• Email: englands@wustl.edu

Arthritis, inflammation, cancer, bone metastases, osteoclasts

• Email: faccior@wustl.edu

Angiogenesis, apoptosis, autophagy, immunology, lymphocyte, tolerance, photoreceptors, vision

• Email: ferguson@vision.wustl.edu

We use both mouse models and patient samples of acute myloid leukemia to understand leukemogenesis and to identify novel therapeutic targets.

• Email: ferrarof@wustl.edu

Identify novel target pathways for therapeutic treatment of obesity-related diseases including diabetes, cardiovascular disease, and fatty liver disease

• Email: bfinck@wustl.edu

High-risk obstetrics, maternal medical conditions complicating pregnancy, preterm birth, abnormal labor

• Email: frolovaa@wustl.edu

Ovarian cancer, receptor tyrosine kinase signaling, metastasis, EMT, tumor microenvironment