Codes and data: https://github.com/YaoChenLabWashU
The promise and peril of comparing fluorescence lifetime in biology revealed by simulations
Pingchuan Ma, Scott Sternson, Yao Chen (2024). eLife. PDF.
A modular chemigenetic calcium indicator for multiplexed in vivo functional imaging
Helen Farrants, Yichun Shuai, William C. Lemon, Christian Monroy Hernandez, Deng Zhang, Shang Yang, Ronak Patel, Guanda Qiao, Michelle S. Frei, Sarah E. Plutkis, Jonathan B. Grimm, Timothy L. Hanson, Filip Tomaska, Glenn C. Turner, Carsen Stringer, Philipp J. Keller, Abraham G. Beyene, Yao Chen, Yajie Liang, Luke D. Lavis & Eric R. Schreiter (2024). Nature Methods, Volume 21:9. PDF.
Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales
Pingchuan Ma, Peter Chen, Elizabeth Tilden, Samarth Aggarwal, Anna Oldenborg, and Yao Chen (2024). Science Advances, Vol. 10, No. 8. PDF.
Fluorescence lifetime imaging captures neuromodulator dynamics at multiple time scales
A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics
Elizabeth I. Tilden, Aditi Maduskar, Anna Oldenborg, Bernardo L. Sabatini and Yao Chen (2024). Scientific Reports volume 14, 3054. PDF.
The Kinase Specificity of Protein Kinase Inhibitor Peptide
Yao Chen and Bernardo L. Sabatini (2021). Frontiers in Pharmacology vol. 12 632815. PDF.
Cell-type-specific asynchronous modulation of PKA by dopamine in learning
Suk Joon Lee, Bart Lodder, Yao Chen, Tommaso Patriarchi, Lin Tian &
Bernardo L. Sabatini (2021). Nature 590: 451–456. PDF.
Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry
Lee S, Chen Y, Lodder B, and Sabatini BL (2019). Frontiers in Neuroscience vol. 13 766. PDF.
Endogenous Gαq-coupled neuromodulator receptors activate protein kinase A
Chen Y, Granger AJ, Tran T, Saulnier JL, Kirkwood A, Sabatini BL (2017). Neuron 96: 1070. PDF.
A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging
Chen Y, Saulnier JL, Yellen G, Sabatini BL (2014). Frontiers in Pharmacology 5: 56. PDF.
Signaling in dendritic spines and spine microdomains
Chen Y and Sabatini BL (2012). Current Opinion in Neurobiology 22: 389-96. PDF.
Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels
Chen Y, Mohammadi M, Flanagan JG (2009). Neuron 62: 773-780. PDF.
Evidence for an upper limit to mitotic spindle length
Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ (2008). Current Biology 18: 1256-61. PDF.
Follow your nose: axon pathfinding in olfactory map formation
Chen Y and Flanagan, J (2006). Cell 127: 881-4. PDF.