Fluorescence lifetime enables high-resolution analysis of neuromodulator dynamics across time and animals
Pingchuan Ma, Peter Chen, Elizabeth Tilden, Samarth Aggarwal, Anna Oldenborg, and Yao Chen. Science Advances, Vol. 10, No. 8, 21 Feb 2024. PDF.
A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics
Elizabeth I. Tilden, Aditi Maduskar, Anna Oldenborg, Bernardo L. Sabatini and Yao Chen. Scientific Reports volume 14, Article number: 3054 (2024) PDF.
Beyond conventional wisdom: unveiling quantitative insights in fluorescence lifetime imaging via realistic simulation of biological systems
Pingchuan Ma and Yao Chen (2023). BioRxiv preprint, this version posted December 21, 2023. PDF.
A modular chemigenetic calcium indicator enables in vivo functional imaging with near-infrared light
Helen Farrants, Yichun Shuai, William C. Lemon, Christian Monroy Hernandez, Shang Yang,
Ronak Patel, Guanda Qiao, Michelle S. Frei, Jonathan B. Grimm, Timothy L. Hanson, Filip
Tomaska, Glenn C. Turner, Carsen Stringer, Philipp J. Keller, Abraham G. Beyene, Yao Chen,
Yajie Liang, Luke D. Lavis, *Eric R. Schreiter. BioRxiv preprint, this version posted July 19, 2023. PDF.
The Kinase Specificity of Protein Kinase Inhibitor Peptide
Yao Chen and Bernardo L. Sabatini (2021). Frontiers in Pharmacology vol. 12 632815. PDF.
Cell-type-specific asynchronous modulation of PKA by dopamine in learning
Suk Joon Lee, Bart Lodder, Yao Chen, Tommaso Patriarchi, Lin Tian &
Bernardo L. Sabatini (2021). Nature 590: 451–456. PDF.
Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry
Lee S, Chen Y, Lodder B, and Sabatini BL (2019). Frontiers in Neuroscience vol. 13 766. PDF.
Endogenous Gαq-coupled neuromodulator receptors activate protein kinase A
Chen Y, Granger AJ, Tran T, Saulnier JL, Kirkwood A, Sabatini BL (2017). Neuron 96: 1070. PDF.
A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging
Chen Y, Saulnier JL, Yellen G, Sabatini BL (2014). Frontiers in Pharmacology 5: 56. PDF.
Signaling in dendritic spines and spine microdomains
Chen Y and Sabatini BL (2012). Current Opinion in Neurobiology 22: 389-96. PDF.
Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels
Chen Y, Mohammadi M, Flanagan JG (2009). Neuron 62: 773-780. PDF.
Evidence for an upper limit to mitotic spindle length
Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ (2008). Current Biology 18: 1256-61. PDF.
Follow your nose: axon pathfinding in olfactory map formation
Chen Y and Flanagan, J (2006). Cell 127: 881-4. PDF.