Codes and data: 

Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales

Pingchuan Ma, Peter Chen, Elizabeth Tilden, Samarth Aggarwal, Anna Oldenborg, and Yao Chen (2024). Science Advances, Vol. 10, No. 8. PDF.


Fluorescence lifetime imaging captures neuromodulator dynamics at multiple time scales

A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics

Elizabeth I. Tilden, Aditi Maduskar, Anna Oldenborg, Bernardo L. Sabatini and Yao Chen (2024). Scientific Reports volume 14, 3054. PDF.

Beyond conventional wisdom: unveiling quantitative insights in fluorescence lifetime imaging via realistic simulation of biological systems

Pingchuan Ma and Yao Chen (2023). BioRxiv preprint, this version posted December 21, 2023. PDF.

A modular chemigenetic calcium indicator enables in vivo functional imaging with near-infrared light

Helen Farrants, Yichun Shuai, William C. Lemon, Christian Monroy Hernandez, Shang Yang,
Ronak Patel, Guanda Qiao, Michelle S. Frei, Jonathan B. Grimm, Timothy L. Hanson, Filip
Tomaska, Glenn C. Turner, Carsen Stringer, Philipp J. Keller, Abraham G. Beyene, Yao Chen,
Yajie Liang, Luke D. Lavis, *Eric R. Schreiter. BioRxiv preprint, this version posted July 19, 2023. PDF.

The Kinase Specificity of Protein Kinase Inhibitor Peptide

Yao Chen and Bernardo L. Sabatini (2021). Frontiers in Pharmacology vol. 12 632815. PDF.

Cell-type-specific asynchronous modulation of PKA by dopamine in learning

Suk Joon Lee, Bart Lodder, Yao Chen, Tommaso Patriarchi, Lin Tian &
Bernardo L. Sabatini (2021). Nature 590: 451–456. PDF.

Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry

Lee S, Chen Y, Lodder B, and Sabatini BL (2019). Frontiers in Neuroscience vol. 13 766. PDF.

Endogenous Gαq-coupled neuromodulator receptors activate protein kinase A

Chen Y, Granger AJ, Tran T, Saulnier JL, Kirkwood A, Sabatini BL (2017). Neuron 96: 1070. PDF.

A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

Chen Y, Saulnier JL, Yellen G, Sabatini BL (2014). Frontiers in Pharmacology 5: 56. PDF.

Signaling in dendritic spines and spine microdomains

Chen Y and Sabatini BL (2012). Current Opinion in Neurobiology 22: 389-96. PDF.

Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels

Chen Y, Mohammadi M, Flanagan JG (2009). Neuron 62: 773-780. PDF.

Evidence for an upper limit to mitotic spindle length

Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ (2008). Current Biology 18: 1256-61. PDF.

Follow your nose: axon pathfinding in olfactory map formation

Chen Y and Flanagan, J (2006). Cell 127: 881-4. PDF.