Washington University in St. Louis has been a leader in neuroscience for nearly a century, including many aspects of systems neuroscience. One prime example is the development of functional neuroimaging, including the first application of this technology to the study of cognitive functions. Research in systems neuroscience is, however, not limited to imaging with burgeoning studies of primate anatomy and physiology, and translational and clinical studies across broad domains. The importance of systems neuroscience involving more than a dozen departments at Washington University encouraged the development of the McDonnell Center for Systems Neuroscience.