** co-first authors, † co-corresponding authors, Millman lab member
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Alessandro Grattoni, Gregory Korbutt, Alice A. Tomei, Andrés J. García, Andrew R. Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R. Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A. Desai, M. Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A. Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi, Esther Latres, Nicholas E. Mamrak, Jaime Giraldo, Mark C. Poznansky, Paul de Vos. Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead. Nature Reviews Endocrinology (2024). Article Link
Marlie M. Maestas, Maggie H. Bui, Jeffrey R. Millman. Recent progress in modeling and treating diabetes using stem cell-derived islets. Stem Cells Translational Medicine (2024). Article Link
Matthew Ishahak, Rowland H. Han, Devi Annamalai, Timothy Woodiwiss, Colin McCornack, Ryan T. Cleary, Patrick A. DeSouza, Xuan Qu, Sonika Dahiya, Albert H. Kim, Jeffrey R. Millman. Modeling glioblastoma tumor progression via CRISPR-engineered brain organoids. bioRxiv (2024). Article Link
, , , , invokes unique cell-type specific responses in primary human pancreatic islets. bioRxiv (2024). Article Link
Marlie M. Maestas, Matthew Ishahak, Punn Augsornworawat, Daniel A. Veronese-Paniagua, Kristina G. Maxwell, Leonardo Velazco-Cruz, Erica Marquez, Jiameng Sun, Mira Shunkarova, Sarah E. Gale, Fumihiko Urano, Jeffrey R. Millman. Identification of unique cell type responses in pancreatic islets to stress. Nature Communications (2024). Article Link
Mason D Schmidt, Matthew Ishahak, Punn Augsornworawat, Jeffrey R. Millman. Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells. BMC Genomics (2024). Article Link
Punn Augsornworawat, Nathaniel J. Hogrebe, Matthew Ishahak, Mason D. Schmidt, Erica Marquez, Marlie M. Maestas, Daniel A. Veronese-Paniagua, Sarah E. Gale, Julia R. Miller, Leonardo Velazco-Cruz, Jeffrey R. Millman. Single-nucleus multi-omics of human stem cell-derived islets identifies deficiencies in lineage specification. Nature Cell Biology (2023). Article Link
Xiaomeng Hu, Kathy White, Ari G. Olroyd, Rowena DeJesus, Antonia A. Dominguez, William E. Dowdle, Annabelle M. Friera, Chi Young, Frank Wells, Elaine Y. Chu, Cade Ellis Ito, Harini Krishnapura, Surbhi Jain, Ramya Ankala, Trevor J. McGill, August Lin, Kyla Egenberger, Allison Gagnon, J. Michael Rukstalis, Nathaniel J. Hogrebe, Corie Gattis, Ron Basco, Jeffrey R. Millman, Paul Kievit, Mark M. Davis, Lewis L. Lanier, Andrew J. Connolly, Tobias Deuse, Sonja Schrepfer. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. Nature Biotechnology (2023). Article Link
Nathaniel J. Hogrebe, Matthew Ishahak, Jeffrey R. Millman. Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes. Cell Stem Cell (2023). Article Link
Xiaomeng Hu, Corie Gattis, Ari G Olroyd, Annabelle M Friera, Kathy White, Chi Young, Ron Basco, Meghan Lamba, Frank Wells, Ramya Ankala, William E Dowdle, August Lin, Kyla Egenberger, J Michael Rukstalis, Jeffrey R Millman, Andrew J Connolly, Tobias Deuse, Sonja Schrepfer. Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice. Science Translational Medicine (2023). Article Link
Daniel A. Domingo-Lopez, Ruth E. Levey, Benjamin Brennan, Oliver Carroll, Sarah E. Gale, Jeffrey R. Millman, Liam McDonough, Helena M. Kelly, William Ronan,Garry P. Duffy. A Predictive Oxygen Durability Model to Analyze Oxygen Consumption of Insulin Producing Cells Encapsulated Within a Highly Oxygenated Hydrogel. Advanced Materials Technologies (2022). Article Link
**Rie Asada Kitamura, **Kristina Maxwell, Wenjuan Ye, Kelly Kries, Cris Brown, Punn Augsornworawat, Yoel Hirsch, Martin Johansson, Tzvi Weiden, Joseph Ekstein, Joshua Cohen, Justin Klee, Kent Leslie, Anton Simeonov, Mark Henderson, †Jeffrey R. Millman, †Fumihiko Urano. Multidimensional analysis and therapeutic development using patient iPSC–derived disease models of Wolfram syndrome. JCI Insight (2022). Article Link
Kristina G. Maxwell, Michelle H Kim, Sarah E Gale, Jeffrey R. Millman. Differential Function and Maturation of Human Stem Cell-Derived Islets After Transplantation. Stem Cells Translational Medicine (2022). Article Link Free-access Link
**Nathaniel Hogrebe, **Kristina G. Maxwell, **Punn Augsornworawat, †Jeffrey R. Millman. Generation of insulin-producing pancreatic β cells from multiple human stem cell lines. Nature Protocols (2021). Article Link
†Jeffrey R. Millman, Jit Hin Tan, †Clark K. Colton. Mouse Pluripotent Stem Cell Differentiation Under Physiological Oxygen Reduces Residual Teratomas. Cellular and Molecular Bioengineering (2021). Article Link Open Access Link
Debkalpa Goswami, Daniel A. Domingo-Lopez, Niamh A. Ward, Jeffrey R. Millman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche. Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes. Advanced Science (2021). Article Link
Xi Wang, Kristina G. Maxwell, Kai Wang, Daniel T. Bowers, James A. Flanders, Wanjun Liu, Long-Hai Wang, Qingsheng Liu, Chengyang Liu, Ali Naji, Yong Wang, Bo Wang, Jing Chen, Alexander U. Ernst, Juan M. Melero-Martin, †Jeffrey R. Millman, †Minglin Ma . A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes. Science Translational Medicine (2021). Article Link
Kristina Maxwell, Jeffrey R Millman. Applications of iPSC-derived beta cells from patients with diabetes. Cell Reports Medicine (2021). Article Link
**Punn Augsornworawat, **Kristina G Maxwell, Leonardo Velazco-Cruz, Jeffrey R Millman. Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after Transplantation. Cell Reports (2020). Article link
Punn Augsornworawat, Jeffrey R Millman. Single-cell RNA Sequencing for Engineering and Studying Human Islets. Current Opinion in Biomedical Engineering (2020) Article Link
Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Jeffrey R Millman. Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells. Frontiers in Bioengineering and Biotechnology (2020) Article Link
Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Kristina G Maxwell, Punn Augsornworawat, Nathaniel J Hogrebe, Jeffrey R Millman. SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Cell Reports (2020). Article link
Kristina G Maxwell, Punn Augsornworawat, Leonardo Velazco-Cruz, Michelle H Kim, Rie Asada, Nathaniel J Hogrebe, Shuntaro Morikawa, †Fumihiko Urano, †Jeffrey R Millman. Gene-edited human stem cell-derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice. Science Translational Medicine (2020). Article link
Nathaniel J. Hogrebe, Punn Augsornworawat, Kristina G. Maxwell, Leonardo Velazco-Cruz, Jeffrey R Millman. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nature Biotechnology. (2020). Article link
**Punn Augsornworawat, **Leonardo Velazco-Cruz, Jiwon Song, Jeffrey R Millman. A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells. Acta Biomaterialia. (2019). Article link
Leonardo Velazco-Cruz, Jiwon Song, Kristina G. Maxwell, Madeleine M. Goedegebuure, Punn Augsornworawat, Nathaniel J. Hogrebe, and Jeffrey R. Millman. Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells. Stem Cell Reports. 12, (2019). Article Link
Jeffrey R. Millman, Teresa Doggett, Christina Thebeau, Sheng Zhang, Clay F. Semenkovich, and Rithwick Rajagopal. Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis. Journal of Visualized Experiments. 143, e58626 (2019). Article Link
†Jeffrey R. Millman and †Felicia W. Pagliuca. Autologous Pluripotent Stem Cell–Derived β-Like Cells for Diabetes Cellular Therapy. Diabetes 66(5):1111-1120 (2017). Article link
Jiwon Song and Jeffrey R. Millman. Economic 3D-Printing Approach for Transplantation of Stem Cell-Derived β Cells. Biofabrication 9(1), 015002 (2016). Article link
†Jeffrey R. Millman, Chunhui Xie, Alana van Dervort, Mads Gürtler, Felicia W. Pagliuca, and †Douglas A. Melton. Generation of stem cell-derived β cells from patients with type 1 diabetes. Nature Communications 7, 11463 (2016). Article link
Arturo J. Vegas, Omid Veiseh, Mads Gürtler, Jeffrey R. Millman, Felicia W. Pagliuca, Andrew R. Bader, Joshua C. Doloff, Jie Li, Michael Chen, Karsten Olejnik, Hok Hei Tam, Siddharth Jhunjhunwala, Erin Langan, Stephanie Aresta-Dasilva, Srujan Gandham, James J. McGarrigle, Matthew A. Bochenek, Jennifer Hollister-Lock, Jose Oberholzer, Dale L. Greiner, Gordon C.Weir, Douglas A. Melton, Robert Langer, Daniel G. Anderson. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nature Medicine 22(3), 306-11 (2016). Article link
**Felicia W. Pagliuca, **Jeffrey R. Millman, **Mads Gurtler, Michael Segel, Alana Van Dervort, Jennifer Hyoje Ryu, Quinn P. Peterson, Dale Greiner, Douglas A. Melton. Generation of Functional Human Pancreatic β Cells In Vitro. Cell 159, 428-39 (2014). Article link
Siniša Hrvatin, Charles W. O’Donnell, Francis Deng, Jeffrey R. Millman, Felicia W. Pagliuca, Philip DiIorio, Alireza Rezania, David K. Gifford, Douglas A. Melton. Differentiated Human Stem Cells Resemble Fetal, Not Adult β Cells. Proceedings of the National Academy of Sciences 111(8), 3038-43 (2014). Article link
**Daryl E. Powers, **Jeffrey R. Millman, Michael Rappel, Clark K. Colton. Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnology Progress 26(3), 805-18 (2010). Article link
**Jeffrey R. Millman, **Jit Hin Tan, Clark K. Colton. The effects of low oxygen on self-renewal and differentiation of embryonic stem cells. Current Opinions in Organ Transplantation 14(6), 694-700 (2009). Article link
**Renita Horton, **Jeffrey R. Millman, Clark K. Colton, Debra Auguste. Engineering microenvironments for embryonic stem cell differentiation to cardiomyocytes. Regenerative Medicine 4(5), 721-32 (2009). Article link
Daryl E. Powers, Jeffrey R. Millman, Ryan B. Huang, Clark K. Colton. Effects of oxygen on mouse embryonic stem cell growth, phenotype retention, and cellular energetics. Biotechnology and Bioengineering 101, 241-54 (2008). Article link
Jeffrey R. Millman, Ketan H. Bhatt, Brian G. Prevo, Orlin D. Velev. Anisotropic particle synthesis in dielectrophoretically controlled microdroplet reactors. Nature Materials 4, 98-102 (2005). Article link