On January 29, 2019, Dean Mary McKay presented at the ICHAD and SMART Africa Speaker Series. Entitled “Adapting HIV Prevention and Care Supports for Youth and Families across Contexts and Systems”, her presentation identified the current challenges children and families face, including the lack of publicly funded services systems, and how we can meet the complex needs of youth and families. Dean McKay further highlighted the CHAMP model (Collaborative HIV prevention and Adolescent Mental Health Project), which aims to bolster key family and youth processes related to youth health and risk taking behaviors. Dean McKay concluded her presentation by explaining how important it is for each study intervention and implementation to be adapted to the particular culture and context of the particular population they are intended for.