Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy (Links to an external site)

Patients with diabetes have a high risk of developing skeletal diseases accompanied by diabetic peripheral neuropathy (DPN). In this study, we isolated the role of DPN in skeletal disease with global and conditional knockout models of sterile-α and TIR-motif-containing protein-1 (Sarm1). SARM1, an NADase highly expressed in the nervous system, regulates axon degeneration upon a […]

Development and Expansion of Intramuscular Adipose Tissue is Not Dependent on UCP-1-Lineage Cells in Mice (Links to an external site)

Accumulation of adipose tissue within and outside of skeletal muscle is associated with orthopedic injury and metabolic disease, where it is thought to impede muscle function. The close juxtaposition between this adipose and myofibers has led to hypotheses that paracrine interactions between the two regulate local physiology. Recent work suggests that intramuscular adipose tissue (IMAT) […]

Congratulations to Samia Saleem on her first ASBMR presentation! (Links to an external site)

“With adequate optimization, GeoMx spatial transcriptomics is a robust tool for bone.” Samia presented her research on Spatial Transcriptomics at the ASBMR Conference in Vancouver. She talked about changes in bone in response to loading and the role of spatial transcriptomics in identifying important genes and pathways.

Xiao Zhang attends the BME leadership retreat in Minnesota.

Xiao Zhang, a PhD student in the Scheller lab attended the Biomedical Engineering retreat in Minnesota. This regional career conference helps strengthen and diversify the next generation of researchers, giving them the opportunity to network with leaders in the field. It also provides a great opportunity to learn from faculty and peers about academic careers […]

Scheller Lab presents posters at MRC Symposium (Links to an external site)

The Scheller Lab members presented their posters at the Musculoskeletal Research Symposium while Dr. Scheller presented her postdoc Dr. Muhammad Hassan’s research. The annual MRC symposium always challenges us to grow by putting our work out there. Congratulations to our experienced pros and first time presenters, and especially Xiao Zhang for taking home one of […]

Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity (Links to an external site)

Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effects, limiting options for therapeutic intervention. The objective of this study was to isolate the role of constitutive […]