We’ll work with you to customize and develop your project based on your ideas, expertise, and interests while leveraging our ongoing work to provide a strong foundation.
- Extracellular regulators of skeletal innervation and repair. Current emphasis is on the study of periostin. Techniques include working with rodent and human samples, high-resolution imaging, fracture/loading, molecular biology, skeletal phenotyping, and dental biology/tooth movement. Possible candidates include trainees at the graduate or post-doctoral level (BME, neurobiology, cell biology, etc).
- Neural regulation of bone marrow adipose tissue expansion and function in health and disease. These investigations build upon our extensive previous publications in this area to define novel regulators of BMAT function and its integration with bone health and peripheral metabolism. Areas of interest include high-resolution imaging, bone/adipose tissue biology, neurobiology, physiology and metabolism, molecular biology, use of rodent and human samples and beyond. Possible candidates include trainees at the graduate or post-doctoral level (neurobiology, physiology, endocrinology, cell biology, etc).
- Peripheral neuropathy as a determinant of musculoskeletal health in adolescents with type 1 diabetes. This is a new clinical project in collaboration with pediatric endocrinology and the bone health clinic at Washington University. Project includes collection and analysis of human data pertaining to bone health (Xtreme CT II) and nerve-muscle-bone interactions in young patients with diabetes. Serial image registration techniques will be developed to augment your interpretation of disease pathogenesis (‘virtual histomorphometry’). Possible candidates include BME graduate students, clinical research fellows (endocrinology, bone health, or pediatrics), and post-doctoral fellows.