Longitudinal Multimodal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer’s Disease


OASIS-3 is a retrospective compilation of data for 1378 participants that were collected across several ongoing projects through the WUSTL Knight ADRC over the course of 30years. Participants include 755 cognitively normal adults and 622 individuals at various stages of cognitive decline ranging in age from 42-95yrs. All participants were assigned a new random identifier and all dates were removed and normalized to reflect days from entry into study. The dataset contains 2842 MR sessions which include T1w, T2w, FLAIR, ASL, SWI, time of flight, resting-state BOLD, and DTI sequences. Many of the MR sessions are accompanied by volumetric segmentation files produced through FreeSurfer processing. PET imaging from different tracers, PIB, AV45, and FDG, totaling over 2157 raw imaging scans and the accompanying post-processed files from the Pet Unified Pipeline (PUP) are also available in OASIS-3. Additionally, 451 Tau PET sessions and post-processed PUP are now available for OASIS-3 subjects in a sub-project ‘OASIS-3_AV1451’.


MR Sessions

PET Sessions

CT Sessions

Publications and Acknowledgements


Acknowledgments: “Data were provided [in part] by OASIS [insert appropriate OASIS source info]”

  1. OASIS-3: Longitudinal Multimodal Neuroimaging: Principal Investigators: T. Benzinger, D. Marcus, J. Morris; NIH P30 AG066444, P50 AG00561, P30 NS09857781, P01 AG026276, P01 AG003991, R01 AG043434, UL1 TR000448, R01 EB009352. AV-45 doses were provided by Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly.
  2. OASIS-3_AV1451: Principal Investigators: T. Benzinger, J. Morris; NIH P30 AG066444, AW00006993. AV-1451 doses were provided by Avid Radiopharmaceuticals, a wholly owned subsidiary of Eli Lilly.


OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease Pamela J LaMontagne, Tammie L.S. Benzinger, John C. Morris, Sarah Keefe, Russ Hornbeck, Chengjie Xiong, Elizabeth Grant, Jason Hassenstab, Krista Moulder, Andrei Vlassenko, Marcus E. Raichle, Carlos Cruchaga, Daniel Marcus, 2019. medRxiv. doi: 10.1101/2019.12.13.19014902

AVID Radiopharmaceuticals Review Information

All proposed publications or presentations using Florbetapir F18 (AV45) or Flortaucipir F18 (AV1451) PET data must be submitted to Avid Radiopharmaceuticals for review and comment thirty days prior to such presentation or publication for review of intellectual property interests. See Imaging data dictionary for contact information and details.

OASIS-3 Imaging Data Dictionary And Methods

The following links contain important links for project documentation.

OASIS-3 Demographic and Clinical Files

Subject 0AS_data_files contains all non-imaging data including the following files:

  • UDS forms: A1, A2, A3, A4-g, A4-d, A5, B1, B2, B3, B4, B5, B6, B7, B8, B9, D1, D2
  • Cognitive Assessments (psychometrics)
  • JSON summary information for MR, PET, CT scans
  • Scan Post-processing files
    • FreeSurfer output spreadsheet
    • PUP output spreadsheet
    • Amyloid Centiloid Values
  • Data Dictionaries:
    • UDS-2 and UDS-3
    • OASIS Imaging Data dictionary
    • OASIS Clinical and Psychometric dictionary
  • Data File Download instructions:
    • Click on MR session (OASIS3_data_files)
    • Select assessments you want to download
    • Bulk action Download
OASIS-3 Scan Download Scripts

The following shell script can be used to download large amounts of data from the OASIS-3 dataset on NITRC-IR.

  1. Create a CSV spreadsheet with a list of sessions to download (or download a CSV from NITRC-IR)
  2. Download the script: https://github.com/NrgXnat/oasis-scripts
  3. Open a Terminal window (on Mac) or Command Line window (on PC / Linux)

To run the script and download data, you need to provide the following parameters:

  • <input_file.csv> – your list of sessions to download
  • <directory_name> – the path to your local download folder
  • <NITRC_username> – your username
  • <scan_type> – (optional) the type of scan or scans to download