Summary: This set consists of a cross-sectional collection of 416 subjects aged 18 to 96. For each subject, 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 100 of the included subjects over the age of 60 have been clinically diagnosed with very mild to moderate Alzheimer’s disease (AD). Additionally, a reliability data set is included containing 20 nondemented subjects imaged on a subsequent visit within 90 days of their initial session.
Summary: This set consists of a longitudinal collection of 150 subjects aged 60 to 96. Each subject was scanned on two or more visits, separated by at least one year for a total of 373 imaging sessions. For each subject, 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 72 of the subjects were characterized as nondemented throughout the study. 64 of the included subjects were characterized as demented at the time of their initial visits and remained so for subsequent scans, including 51 individuals with mild to moderate Alzheimer’s disease. Another 14 subjects were characterized as nondemented at the time of their initial visit and were subsequently characterized as demented at a later visit.
Summary: OASIS-3 is a retrospective compilation of data for 1378 participants that were collected across several ongoing projects through the WUSTL Knight ADRC over the course of 30years. Participants include 755 cognitively normal adults and 622 individuals at various stages of cognitive decline ranging in age from 42-95yrs. All participants were assigned a new random identifier and all dates were removed and normalized to reflect days from entry into study. The dataset contains 2842 MR sessions which include T1w, T2w, FLAIR, ASL, SWI, time of flight, resting-state BOLD, and DTI sequences. Many of the MR sessions are accompanied by volumetric segmentation files produced through FreeSurfer processing. PET imaging from different tracers, PIB, AV45, and FDG, totaling over 2157 raw imaging scans and the accompanying post-processed files from the Pet Unified Pipeline (PUP) are also available in OASIS-3. Additionally, 451 Tau PET sessions and post-processed PUP are now available for OASIS-3 subjects in a sub-project ‘OASIS-3_AV1451’.
Summary: An additional 451 Tau PET sessions and post-processed PUP are now available for OASIS-3 subjects in a sub-project ‘OASIS-3_AV1451’.
This dataset requires a unique data request at the following link: https://sites.wustl.edu/oasisbrains/home/oasis-3/request-tau-access/
Summary: This set consists of a collection of 663 subjects aged 21 to 94. This clinical cohort was evaluated for memory disorders and dementia including clinical, csf, neurospychometric, and neuroimaging assessments.
This is a unique OASIS dataset and not an update to the OASIS-3 Longitudinal Multimodal Neuroimaging datasets.