PreMIER (Precision Medicine Integrated Experimental Resource)
Harnessing the power of model systems to unravel the complexities of human development and disease
PreMIER (Precision Medicine Integrated Experimental Resource) is a panel of experts that directs clinicians and researchers to appropriate model systems and resources at Washington University, to facilitate progress in our fundamental understanding of biology related to human health and disease. My laboratory coordinates PreMIER’s connections between patients and clinicians and human stem cell and organoid models, while we use these models to assess how gene variants found in patients cause neurodevelopmental disorders.
Radio Interview
Radio Interview over AP article for a station in Melbourne, AU. The interview starts around 1:07:13.
Research Article
Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons
Lewis, E.M.A., Meganathan, K., Baldridge, D. et al. Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons. Molecular Autism 10, 51 (2019) doi:10.1186/s13229-019-0306-0
Research Article
Alterations in neuronal physiology, development, and function associated with a common duplication of chromosome 15 involving CHRNA7
Meganathan K, Prakasam R, Baldridge D, Gontarz P, Zhang B, Urano F, Bonni A, Constantino JN, Kroll KL. Alterations in neuronal physiology, development, and function associated with a common duplication of chromosome 15 involving CHRNA7. bioRxiv. Forthcoming; https://doi.org/10.1101/2020.01.28.922187.
Research Article
Balancing Serendipity and Reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders
Anderson NC, Chen PF, Meganathan K, Afshar Saber W, Bhattacharyya A, Kroll K, and Sabin M on behalf of the Cross-IDDRC Human Stem Cell Working Group. Balancing Serendipity and Reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders.Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2021.03.025
Research Article
Epigenetic regulation during human cortical development: seq-ing answers from the brain to the organoid
Emily M. A. Lewisa, Komal Kaushika, Luke A. Sandovala, Irene Antonya, Sabine Dietmanna, Kristen L. Krolla* Epigenetic regulation during human cortical development: seq-ing answers from the brain to the organoid. https://doi.org/10.1016/j.neuint.2021.105039
Research Article
New models to understand the intricacies of neurodevelopmental disorders
Scientia. https://doi.org/10.33548/SCIENTIA663
Research Article
Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2
Lewis EMA, Chapman G, Kaushik K, Determan J, Antony I, Meganathan K, Narasimhan M, Gontarz P, Zhang B, Kroll KL. Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2. Sci Rep. 2022 Sep 17;12(1):15636. doi: 10.1038/s41598-022-19654-y.