Chapman G, Determan J, Jetter H, Kaushik K, Prakasam R, Kroll KL. Defining cis-regulatory elements and transcription factors that control human cortical interneuron development. iScience. 2024 May 11;27(6):109967. doi: 10.1016/j.isci.2024.109967. PMID: 38827400; PMCID: PMC11140214.
Antony I, Narasimhan M, Shen R, Prakasam R, Kaushik K, Chapman G, Kroll KL. Duplication Versus Deletion Through the Lens of 15q13.3: Clinical and Research Implications of Studying Copy Number Variants Associated with Neuropsychiatric Disorders in Induced Pluripotent Stem Cell-Derived Neurons. Stem Cell Rev Rep. 2023 Apr;19(3):639-650. doi: 10.1007/s12015-022-10475-0. Epub 2022 Nov 12. PMID: 36370261; PMCID: PMC10115185.
Lewis EMA*, Chapman G*, Kaushik K, Determan J, Antony I, Meganathan K, Narasimhan M, Gontarz P, Zhang B, Kroll KL. Regulation of human cortical interneuron development by the chromatin remodeling protein CHD2. Sci Rep. 2022 Sep 17;12(1):15636. doi: 10.1038/s41598-022-19654-y. PMID: 36115870; PMCID: PMC9482661.
*Authors contributed equally to this work.
Meganathan K, Prakasam R, Kaushik K, Chapman G, Antony I, Kroll KL. Derivation of cortical interneurons from human pluripotent stem cells to model neurodevelopmental disorders. In: Buttermore E, editor. Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research. Amsterdam, Netherlands: Elsevier; 2022 Sep 9. p. 45-72. doi: 10.1016/B978-0-12-822277-5.00007-9
Kfoury-Beaumont N, Prakasam R, Pondugula S, Lagas JS, Matkovich S, Gontarz P, Yang L, Yano H, Kim AH, Rubin JB, Kroll KL. The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential. BMC Biol. 2022 May 30;20(1):124. doi: 10.1186/s12915-022-01324-0. PMID: 35637482; PMCID: PMC9153095.
Chapman G, Antony I, Narasimhan M, Shen R, Elman R, Kroll KL. Cellular and Molecular Neurobiology of Autism Spectrum Disorder. In: Kana R, editor. The Neuroscience of Autism. Amsterdam, Netherlands: Elsevier; 2022 May 27. p. 215-244. doi: 10.1016/B978-0-12-816393-1.00007-5.
Lewis EMA, Kaushik K, Sandoval LA, Antony I, Dietmann S, Kroll KL. Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid. Neurochem Int. 2021 Jul;147:105039. doi: 10.1016/j.neuint.2021.105039. Epub 2021 Apr 27. PMID: 33915225; PMCID: PMC8387070.
Anderson NC, Chen PF, Meganathan K, Afshar Saber W, Petersen AJ, Bhattacharyya A, Kroll KL, Sahin M; Cross-IDDRC Human Stem Cell Working Group. Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders. Stem Cell Reports. 2021 Jun 8;16(6):1446-1457. doi: 10.1016/j.stemcr.2021.03.025. Epub 2021 Apr 15. PMID: 33861989; PMCID: PMC8190574.
Meganathan K, Prakasam R, Baldridge D, Gontarz P, Zhang B, Urano F, Bonni A, Maloney SE, Turner TN, Huettner JE, Constantino JN, Kroll KL. Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7. BMC Biol. 2021 Jul 28;19(1):147. doi: 10.1186/s12915-021-01080-7. PMID: 34320968; PMCID: PMC8317352.
Lewis EMA, Sankar S, Tong C, Patterson ES, Waller LE, Gontarz P, Zhang B, Ornitz DM, Kroll KL. Geminin is required for Hox gene regulation to pattern the developing limb. Dev Biol. 2020 Aug 1;464(1):11-23. doi: 10.1016/j.ydbio.2020.05.007. Epub 2020 May 23. PMID: 32450229; PMCID: PMC8362291.
Lewis EMA*, Meganathan K*, Baldridge D, Gontarz P, Zhang B, Bonni A, Constantino JN, Kroll KL. Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons. Mol Autism. 2019 Dec 30;10:51. doi: 10.1186/s13229-019-0306-0. PMID: 31893020; PMCID: PMC6936127.
*Authors contributed equally to this work.
Meganathan K, Prakasam R, Kroll KL. A translational rheostat integrates euchromatin regulation and growth of pluripotent embryonic cells. Stem Cell Investig. 2019 May 21;6:11. doi: 10.21037/sci.2019.05.01. PMID: 31231668; PMCID: PMC6556695.
Lewis EM, Kroll KL. Development and disease in a dish: the epigenetics of neurodevelopmental disorders. Epigenomics. 2018 Feb;10(2):219-231. doi: 10.2217/epi-2017-0113. Epub 2018 Jan 15. PMID: 29334242; PMCID: PMC5810842.
Meganathan K, Lewis EMA, Gontarz P, Liu S, Stanley EG, Elefanty AG, Huettner JE, Zhang B, Kroll KL. Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11180-E11189. doi: 10.1073/pnas.1712365115. Epub 2017 Dec 11. PMID: 29229852; PMCID: PMC5748186.
Sankar S, Patterson E, Lewis EM, Waller LE, Tong C, Dearborn J, Wozniak D, Rubin JB, Kroll KL. Geminin deficiency enhances survival in a murine medulloblastoma model by inducing apoptosis of preneoplastic granule neuron precursors. Genes Cancer. 2017 Sep;8(9-10):725-744. doi: 10.18632/genesandcancer.157. PMID: 29234490; PMCID: PMC5724806.
Zhang B, Madden P, Gu J, Xing X, Sankar S, Flynn J, Kroll K, Wang T. Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. BMC Genomics. 2017 Jun 5;18(1):439. doi: 10.1186/s12864-017-3813-4. PMID: 28583088; PMCID: PMC5460472.
Sankar S, Yellajoshyula D, Zhang B, Teets B, Rockweiler N, Kroll KL. Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1. Sci Rep. 2016 Nov 24;6:37412. doi: 10.1038/srep37412. PMID: 27881878; PMCID: PMC5121602.
Dandulakis MG, Meganathan K, Kroll KL, Bonni A, Constantino JN. Complexities of X chromosome inactivation status in female human induced pluripotent stem cells-a brief review and scientific update for autism research. J Neurodev Disord. 2016 Jun 9;8:22. doi: 10.1186/s11689-016-9155-8. PMID: 27303449; PMCID: PMC4907282.
Corley M, Kroll KL. The roles and regulation of Polycomb complexes in neural development. Cell Tissue Res. 2015 Jan;359(1):65-85. doi: 10.1007/s00441-014-2011-9. Epub 2014 Nov 1. PMID: 25367430; PMCID: PMC4286515.
Patterson ES, Waller LE, Kroll KL. Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation. Dev Biol. 2014 Sep 1;393(1):44-56. doi: 10.1016/j.ydbio.2014.06.021. Epub 2014 Jul 1. PMID: 24995796; PMCID: PMC4134736.
Caronna EA, Patterson ES, Hummert PM, Kroll KL. Geminin restrains mesendodermal fate acquisition of embryonic stem cells and is associated with antagonism of Wnt signaling and enhanced polycomb-mediated repression. Stem Cells. 2013 Aug;31(8):1477-87. doi: 10.1002/stem.1410. PMID: 23630199; PMCID: PMC3776023.
Siles L, Sánchez-Tilló E, Lim JW, Darling DS, Kroll KL, Postigo A. ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression. Mol Cell Biol. 2013 Apr;33(7):1368-82. doi: 10.1128/MCB.01259-12. Epub 2013 Jan 22. PMID: 23339872; PMCID: PMC3624276.
Yellajoshyula D, Lim JW, Thompson DM Jr, Witt JS, Patterson ES, Kroll KL. Geminin regulates the transcriptional and epigenetic status of neuronal fate-promoting genes during mammalian neurogenesis. Mol Cell Biol. 2012 Nov;32(22):4549-60. doi: 10.1128/MCB.00737-12. Epub 2012 Sep 4. PMID: 22949506; PMCID: PMC3486176.
Ishibashi S, Kroll KL, Amaya E. Generating transgenic frog embryos by restriction enzyme mediated integration (REMI). Methods Mol Biol. 2012;917:185-203. doi: 10.1007/978-1-61779-992-1_11. PMID: 22956089; PMCID: PMC3818119.
Sengupta R, Dubuc A, Ward S, Yang L, Northcott P, Woerner BM, Kroll K, Luo J, Taylor MD, Wechsler-Reya RJ, Rubin JB. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Res. 2012 Jan 1;72(1):122-32. doi: 10.1158/0008-5472.CAN-11-1701. Epub 2011 Nov 3. PMID: 22052462; PMCID: PMC3520097.
Yellajoshyula D, Patterson ES, Elitt MS, Kroll KL. Geminin promotes neural fate acquisition of embryonic stem cells by maintaining chromatin in an accessible and hyperacetylated state. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3294-9. doi: 10.1073/pnas.1012053108. Epub 2011 Feb 7. PMID: 21300881; PMCID: PMC3044367.
He Z, Cai J, Lim JW, Kroll K, Ma L. A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J Biol Chem. 2011 Mar 4;286(9):7279-89. doi: 10.1074/jbc.M110.178780. Epub 2010 Dec 21. PMID: 21177534; PMCID: PMC3044984.
Lim JW, Hummert P, Mills JC, Kroll KL. Geminin cooperates with Polycomb to restrain multi-lineage commitment in the early embryo. Development. 2011 Jan;138(1):33-44. doi: 10.1242/dev.059824. Epub 2010 Nov 23. PMID: 21098561; PMCID: PMC2998164.
Amaya E, Kroll K. Production of transgenic Xenopus laevis by restriction enzyme mediated integration and nuclear transplantation. J Vis Exp. 2010 Aug 21;(42):2010. doi: 10.3791/2010. PMID: 20811326; PMCID: PMC3156005.
Ishibashi S, Kroll KL, Amaya E. A method for generating transgenic frog embryos. Methods Mol Biol. 2008;461:447-66. doi: 10.1007/978-1-60327-483-8_31. PMID: 19030816; PMCID: PMC3814177.
Langer EM, Feng Y, Zhaoyuan H, Rauscher FJ 3rd, Kroll KL, Longmore GD. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell. 2008 Mar;14(3):424-36. doi: 10.1016/j.devcel.2008.01.005. PMID: 18331720; PMCID: PMC2279146.
Seo S, Lim JW, Yellajoshyula D, Chang LW, Kroll KL. Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J. 2007 Dec 12;26(24):5093-108. doi: 10.1038/sj.emboj.7601923. Epub 2007 Nov 15. PMID: 18007592; PMCID: PMC2140110.
Yellajoshyula D, Patterson ES, Kroll KL. Maternal cyclin B levels “Chk” the onset of DNA replication checkpoint control in Drosophila. Bioessays. 2007 Oct;29(10):949-52. doi: 10.1002/bies.20646. PMID: 17876773.
Lauberth SM, Bilyeu AC, Firulli BA, Kroll KL, Rauchman M. A phosphomimetic mutation in the Sall1 repression motif disrupts recruitment of the nucleosome remodeling and deacetylase complex and repression of Gbx2. J Biol Chem. 2007 Nov 30;282(48):34858-68. doi: 10.1074/jbc.M703702200. Epub 2007 Sep 25. PMID: 17895244.
Ishibashi S, Kroll KL, Amaya E. Generation of Transgenic Xenopus laevis: I. High-Speed Preparation of Egg Extracts. CSH Protoc. 2007 Sep 1;2007:pdb.prot4838. doi: 10.1101/pdb.prot4838. PMID: 21357171.
Ishibashi S, Kroll KL, Amaya E. Generation of Transgenic Xenopus laevis: II. Sperm Nuclei Preparation. CSH Protoc. 2007 Sep 1;2007:pdb.prot4839. doi: 10.1101/pdb.prot4839. PMID: 21357172.
Ishibashi S, Kroll KL, Amaya E. Generation of Transgenic Xenopus laevis: III. Sperm Nuclear Transplantation. CSH Protoc. 2007 Sep 1;2007:pdb.prot4840. doi: 10.1101/pdb.prot4840. PMID: 21357173.
Kroll KL. Geminin in embryonic development: coordinating transcription and the cell cycle during differentiation. Front Biosci. 2007 Jan 1;12:1395-409. doi: 10.2741/2156. PMID: 17127390.
Boos A, Lee A, Thompson DM, Kroll KL. Subcellular translocation signals regulate Geminin activity during embryonic development. Biol Cell. 2006 Jun;98(6):363-75. doi: 10.1042/BC20060007. PMID: 16464175.
Seo S, Kroll KL. Geminin’s double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation. Cell Cycle. 2006 Feb;5(4):374-9. doi: 10.4161/cc.5.4.2438. Epub 2006 Feb 15. PMID: 16479171.
Taylor JJ, Wang T, Kroll KL. Tcf- and Vent-binding sites regulate neural-specific geminin expression in the gastrula embryo. Dev Biol. 2006 Jan 15;289(2):494-506. doi: 10.1016/j.ydbio.2005.10.047. Epub 2005 Dec 9. PMID: 16337935.
Concurrent commentary on Seo et al., 2005:
Aigner S, Gage FH. A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug;9(2):171-2. doi: 10.1016/j.devcel.2005.07.005. PMID: 16054024.
Seo S, Herr A, Lim JW, Richardson GA, Richardson H, Kroll KL. Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev. 2005 Jul 15;19(14):1723-34. doi: 10.1101/gad.1319105. PMID: 16024661; PMCID: PMC1176010.
Seo S, Richardson GA, Kroll KL. The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. Development. 2005 Jan;132(1):105-15. doi: 10.1242/dev.01548. Epub 2004 Dec 2. PMID: 15576411.
Postigo AA, Depp JL, Taylor JJ, Kroll KL. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 2003 May 15;22(10):2453-62. doi: 10.1093/emboj/cdg226. PMID: 12743039; PMCID: PMC155984.
Bainter JJ, Boos A, Kroll KL. Neural induction takes a transcriptional twist. Dev Dyn. 2001 Nov;222(3):315-27. doi: 10.1002/dvdy.1210. PMID: 11747068.