2024

Egervari G*#Alexander DC*, Donahue G, Huang H, Hogan C, Mendoza M, Garcia BA, Bonini NM, Berger SL#. ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer’s disease. bioRxiv, 2024

2023

Egervari G#Donahue G, Quijano-Carde N, Hogan C, Periandri EM, Fleites V, Alexander DC, De Biasi M, Berger SL#. Decreased voluntary alcohol intake and ventral striatal epigenetic and transcriptional remodeling in male Acss2 KO mice. bioRxiv, 2023

Sen P, Donahue G, Li C, Lan Y, Egervari GRobertson N, Shah P, Kerkhoven E, Schultz D, Adams P, Berger SL. Spurious intragenic transcription is a hallmark of mammalian cellular senescence and tissue agingNature Aging, 2023 Mar;3:402-417

2022

Alexander DC, Corman T, Mendoza M, Glass A, Belity T, Campbell R, Han J, Keiser A, Winkler J, Wood MA, Kim T, Garcia BA, Cohen H, Mews P#Egervari G#, Berger SL#. Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylationProceedings of the National Academy of Sciences, 2022 Aug 9;119(32):e2114758119.

Dmitrieva-Posocco O, Wong AC, Lundgren P, Golos AM, Descamps HC, Dohnalova L, Cramer Z, Tian Y, Yueh B, Eskiocak O, Egervari G, Lan Y, Liu J, Fan J, Kim J, Madhu B, Schneider KM, Khoziainova S, Andreeva N, Wang Q, Li N, Furth EE, Bailis W, Kelsen JR, Hamilton KE, Kaestner KH, Berger SL, Epstein JA, Jain R, Li M, Beyaz S, Lengner CJ, Katona BW, Grivennikov SI, Thaiss CA, Levy M. Beta-hydroxybutyrate suppresses colorectal cancerNature, 2022 May;605(7908):160-165

Mendoza M*, Egervari G*#, Donahue G, Sidoli S, Alexander DC, Sen P, Garcia BA#, Berger SL#. Enzymatic transfer of acetate on histones from lysine reservoir sites to lysine activating sitesScience Advances, 2022 Jan 21;8(3):eabj5688.

2021

Egervari G#, Siciliano CA#, Whiteley E, Ron D#Alcohol and the brain: from genes to circuitsTrends in Neurosciences, 2021 Dec;44(12):1004-1015

Egervari G#Chromatin accessibility in neuropsychiatric disordersNeurobiology of Learning and Memory, 2021 May;181:107438

2020

Egervari G, Glastad KM, Berger SL. Food for thoughtScience, 2020 Nov;370(6517):660-662

Egervari G, Akpoyibo D, Rahman T, Fullard JF, Callens JE, Landry JA, Ly A, Zhou X, Warren N, Hauberg M, Hoffmann G, Ellis R, Ferland JN, Miller ML, Keller E, Zhang B, Roussos P, Hurd YL. Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorderNature Communications, 2020 Sep 14;11(1):4634

Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL. Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesityMolecular Psychiatry 2020 Sep;25(9):2058-2069

2019

Mews P*, Egervari G*#, Nativio R, Sidoli S, Donahue G, Lombroso SI, Alexander DC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL#. Alcohol metabolism contributes to brain histone acetylationNature, 2019 Oct;574(7780):717-721

Egervari G, Kozlenkov A, Dracheva S, Hurd YL. Molecular windows into the human brain for psychiatric disordersMolecular Psychiatry 2019 May;24(5):653-673

Miller ML, Chadwick B, Dickstein D, Purushothaman I, Egervari G, Rahman T, Tessereau C, Hof PR, Roussos P, Shen L, Baxter M, Hurd YL. Adolescent exposure to d9-tetrahydrocannabinol alters the transcriptional projectory and dendritic architecture of prefrontal pyramidal neuronsMolecular Psychiatry, 2019 Mar;24(4):588-600

2018

Xi L*, Egervari G*, Wang Y, Berger SL, Lu Z. Regulation of chromatin and gene expression by metabolic enzymes and metabolitesNature Reviews Molecular Cell Biology 2018 Sep;19(9):563-578 

Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P. An atlas of chromatin accessibility in the adult human brainGenome Research, 2018 Aug;28(8):1243-1252

Miller ML, Ren Y, Szutorisz H, Warren N, Tessereau C, Egervari G, Mlodnicka A, Chaarani B, Morris C, Schumann G, Garavan H, Bannon M, Halperin J, Kapoor M, Goete A, Hurd YL. Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerabilityMolecular Psychiatry, 2018 May;23(5):1328-1335

Egervari G, Ciccocioppo R, Jentsch JD, Hurd YL. Shaping individual addiction vulnerability – the contribution of behavior, neural circuits and molecular mechanismsNeuroscience and Biobehavoral Reviews, 2018 Feb;85:117-125

2017

Michaelides M, Miller ML, DiNieri JA, Gomez JL, Schwartz E, Egervari G, Wang GJ, Mobbs CV, Volkow ND, Hurd YL. Dopamine D2 receptor signaling in the nucleus accumbens comprises a metabolic-cognitive brain interface regulating metabolic components of glucose reinforcementNeuropsychopharmacology, 2017 Nov;42(12):2365-2376

Egervari G#, Rahman T. Increased firing of lateral habenula neurons mediates ethanol aversion – potential implications for substance use disordersJournal of Physiology, 2017 Jul 1;595(13):4135-4136

Egervari G, Landry J, Callens J, Fullard JF, Roussos P, Keller E, Hurd YL. Striatal H3K27 acertylation linked to glutamatergic gene dysregulation in human heroin abusers holds promise as therapeutic targetBiological Psychiatry 2017 Apr 1;81(7):585-594

2016

Szutorisz H, Egervari G, Sperry J, Carter JM, Hurd YL. Cross-generational THC exposure alters the developmental sensitivity of ventral and dorsal striatal gene expression in male and female offspringNeurotoxicology and Teratology 2016 Nov – Dec;58:107-114

Egervari G#. AMPA receptor plasticity in the nucleus accumbens mediates withdrawal-related negative-affective statesJournal of Neuroscience, 2016 Oct 12;36(41):10505-10507

Egervari G*, Jutras-Aswad D*, Landry J, Miller ML, Anderson SA, Michaelides M, Jacobs MM, Peter C, Yiannoulos G, Liu X, Hurd YL. A functional 3’UTR polymorphism (rs2235749) of prodynorphin alters microRNA-365 binding in ventral striatonigral neurons to influence novelty seeking and positive reward traitsNeuropsychopharmacology 2016 Sep;41(10):2512-2520

2015

Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Peña CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonté B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental areaNature Neuroscience 2015 Mar;18(3):415-22

2014

Szutorisz H, DiNieri, JA, Sweet E, Egervari G, Michaelides M, Carter JM, Ren Y, Miller ML, Blitzer RD, Hurd YL. Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generationNeuropsychopharmacology 2014 May;39(6):1315-23

2011

Egervari G*, Mark A*, Hajdu M, Barna G, Sapi Z, Krenacs T, Kopper L, Sebestyen A. Mitotic lymphoma cells are characterized by high expression of phosphorylated ribosomal S6 proteinHistochemistry and Cell Biology 2011 Apr;135(4):409-17