Metabolic-epigenetic interactions

in the healthy and diseased brain

Our goal is to elucidate how metabolic changes influence gene expression in the brain in physiological and pathological states. We combine state-of-the art proteomic, genomic and metabolomic approaches including on the single cell level, with quantitative and mechanistic studies, using disease-relevant in vitro and in vivo models. Our hope is that this work will identify new therapeutic targets for a variety of human diseases, and transform our understanding of how the brain adapts to environmental stimuli.