Adverse childhood experiences (ACEs) are, unfortunately, familiar in American Indian and Alaska Native (AI/AN) communities, where factors such as poverty, unemployment, chronic stress and intergenerational trauma contribute to ACEs and their resulting detrimental effects (Warne et al., 2017). Recognizing that AI/AN populations are disproportionately impacted by trauma requires translating research into appropriate interventions. The Indian Country Child Trauma Center (ICCTC) developed cultural adaptations of two evidence-based practices, Trauma Focused Cognitive Behavior Therapy and Problematic Sexual Behavior Cognitive Behavior Therapy (PSB-CBT), to mitigate the impact of trauma and ACEs with AI/AN youth. A brief overview of ACEs within the AI/AN context is provided, along with a description of these culturally enhanced treatments and implications for future research, practice and policy.