Click here to view the full list of Dr. Rajendra S. Apte’s NCBI publications on PubMed
Fundamental Research
Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function. Lee TJ, Sasaki Y, Ruzycki PA, Ban N, Lin JB, Wu HT, Santeford A, Apte RS. JCI Insight. 2024 Jan 16:e173707. doi: 10.1172/jci.insight.173707.
Targeting cell-type-specific, choroid-peripheral immune signaling to treat age-related macular degeneration. Lin JB, Santeford A, Colasanti JJ, Lee Y, Shah AV, Wang TJ, Ruzycki PA, Apte RS. Cell Rep Med. 2024 Jan 16;5(1):101353. doi: 10.1016/j.xcrm.2023.101353.PMID: 38232696
Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. Pfeifer CW, Walsh JT, Santeford A, Lin JB, Beatty WL, Terao R, Liu YA, Hase K, Ruzycki PA, Apte RS. Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2308214120. doi: 10.1073/pnas.2308214120. Epub 2023 Oct 30. PMID: 37903272
Cell-specific systemic immune signatures associated with treatment burden in neovascular age-related macular degeneration. Lin JB, Santeford A, Usmani D, Shah AV, Ruzycki PA, Apte RS. Ophthalmology Science. (2023) 10.1016/j.xops.2023.100410.
Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in macrophages. Lin JB, Mora A, Wang TJ, Santeford A, Usmani D, Ligon MM, Mysorekar IU, Apte RS. mBio. 2023 Aug 31;14(4):e0092523. doi: 10.1128/mbio.00925-23. Epub 2023 Jul 7. PMID: 37417745
Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis. Lin JB, Shen X, Pfeifer CW, Shiau F, Santeford A, Ruzycki PA, Clark BS, Liu Q, Huang AJW, Apte RS. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2204134120. doi: 10.1073/pnas.2204134120. Epub 2023 Jan 3.PMID: 36595669
The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses. Cook ME, Bradstreet TR, Webber AM, Kim J, Santeford A, Harris KM, Murphy MK, Tran J, Abdalla NM, Schwarzkopf EA, Greco SC, Halabi CM, Apte RS, Blackshear PJ, Edelson BT. Sci Immunol. 2022 Oct 28;7(76):eabo0981. doi: 10.1126/sciimmunol.abo0981. PMID: 36269839
EML1 is essential for retinal photoreceptor migration and survival. Poria D, Sun C, Santeford A, Kielar M, Apte RS, Kisselev OG, Chen S, Kefalov VJ. Sci Rep. 2022 Feb 21;12(1):2897. doi: 10.1038/s41598-022-06571-3. PMID: 35190581
Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages. Santeford A, Lee AY, Sene A, Hassman LM, Sergushichev AA, Loginicheva E, Artyomov MN, Ruzycki PA, Apte RS. Elife. 2021 Aug 23;10:e66703. doi: 10.7554/eLife.66703. Online ahead of print. PMID: 34423778
HSV-1 and Zika but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon. Miner JJ, Plat DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA, Apte RS. Cell Rep. 2020 Nov 3;33(5)e108339. dio:10.1016/j.celrep.2020.108339. PMID: 33147451
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration.Elife. 2020 Oct 27;9:e62027. doi: 10.7554/eLife.62027. PMID:33107823
LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. JCI Insight. 2020 Jan 16;5(1):e131928. doi: 10.1172/jci.insight.131928. PMID: 31829999
FGF2-induced STAT3 activation regulates pathologic neovascularization. Dong Z, Santeford A, Ban N, Lee TJ, Smith C, Ornitz DM, Apte RS. Exp Eye Res. 2019 Aug 23;187:107775. doi: 10.1016/j.exer.2019.107775. PMID: 31449793
Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Yoshida M, Satoh A, Lin JB, Mills KF, Sasaki Y, Rensing N, Wong M, Apte RS, Imai SI. Cell Metab. 2019 Jun 7. pii: S1550-4131(19)30255-4. doi:0.1016/j.cmet.2019.05.015. PMID: 31204283
Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes. Lin JB, Lin JB, Chen HC, Chen T, Apte RS. Sci Rep. 2019 Mar 7;9(1):3799. doi:10.1038/s41598-019-40177-6. PMID: 30846716
Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. Ban N, Lee TJ, Sene A, Choudhary M, Lekwuwa M, Dong Z, Santeford A, Lin JB, Malek G, Ory DS, Apte RS. JCI Insight. 2018 Sep 6;3(17). pii: 120824. doi:10.1172/jci.insight.120824. eCollection 2018 Sep 6. PMID: 30185655
Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. Ban N, Lee TJ, Sene A, Dong Z, Santeford A, Lin JB, Ory DS, Apte RS. J Lipid Res. 2018 Aug;59(8):1414-1423. doi: 10.1194/jlr.M084442. Epub 2018 Jun 26. PMID: 29946056
Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging. Lin JB, Sene A, Santeford A, Fujiwara H, Sidhu R, Ligon MM, Shankar VA, Ban N, Mysorekar IU, Ory DS, Apte RS. EBioMedicine. 2018 Jun;32:9-20. doi: 10.1016/j.ebiom.2018.05.035. Epub 2018 Jun 11. PMID: 29903570
WNT7A/B promote choroidal neovascularization. Lin JB, Sene A, Wiley LA, Santeford A, Nudleman E, Nakamura R, Lin JB, Moolani HV, Apte RS. Exp Eye Res. 2018 Sep;174:107-112. doi: 10.1016/j.exer.2018.05.033. Epub 2018 Jun 1. PMID: 29864439
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN. Nature. 2018 Apr;556(7702):501-504. doi: 10.1038/s41586-018-0052-z. Epub 2018 Apr 18. PMID: 29670287
NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E520-E530. doi: 10.1152/ajpendo.00057.2018. Epub 2018 Apr 10. PMID: 29634313
Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration. Lin JB, Moolani HV, Sene A, Sidhu R, Kell P, Lin JB, Dong Z, Ban N, Ory DS, Apte RS. JCI Insight. 2018 Apr 5;3(7). pii: 120157. doi: 10.1172/jci.insight.120157. eCollection 2018 Apr 5. PMID: 29618664
Translational Research
Multimodal Structural and Functional Characterization of Retinal Vasculopathy and Cerebral
Leukoencephalopathy. Wang W.X., Shah A.V., Bruck B., Van Stavern G., Rao P.K. & Apte R.S. Ophthalmology Retina. 2023 Oct 27. doi: 10.1016/j.oret.2023.10.013
Association of Systemic Lupus Erythematosus Disease Activity With Choroidal Thickness. Lee I, Gomez AR, Kim AHJ, Coble DW, Marshall B, Shah A, Eisen S, Apte RS, Li T. J Clin Rheumatol. 2023 Oct 12. doi: 10.1097/RHU.0000000000002036. PMID: 37798827
Vitreous microparticles contain apoptotic signals suggesting a diabetic vitreopathy. Sultan H, Rajagopal R, Rao PK, Piggott KD, Paley MA, Hassman LM, Li AS, Marshall B, Apte RS. Int J Ophthalmol. 2022 Jan 18;15(1):89-97. doi: 10.18240/ijo.2022.01.14. PMID: 35047362; PMCID: PMC8720341.
Dexamethasone implant improves anatomic response to anti-VEGF therapy in treatment-resistant polypoidal choroidal vasculopathy. Mallikarjun K, Narayanan R, Raman R, Mohamed A, Shanmugam MP, Apte RS, Padhy SK. Int Ophthalmol. 2021 Nov 9. doi: 10.1007/s10792-021-02113-4. Epub 2021 Nov 9. PMID: 34755239.
New-Onset Macular Schisis in a Patient With Glaucoma. Wilke GA, O’Bryhim BE, Apte RS. JAMA Ophthalmol. 2021;139(11):1236–1237. doi:10.1001/jamaophthalmol.2021.0939. PMID: 34473207.
OCT Angiography Findings in Preclinical Alzheimer’s Disease: 3-Year Follow-Up. O’Bryhim BE, Lin JB, Van Stavern GP, Apte RS. Ophthalmology. 2021 Oct;128(10):1489-1491. doi: 10.1016/j.ophtha.2021.02.016. Epub 2021 Feb 19. PMID: 33610626.
OCTA Findings in Pre-Clinical Alzheimer’s Disease: 3 Year Follow-Up. O’Bryhim BE, Lin JB, Van Stavern GP, Apte RS. Ophthalmology. 2021 Feb 18:S0161-6420(21)00128-7. doi: 10.1016/j.ophtha.2021.02.016. Epub ahead of print. PMID: 33610626
Longitudinal Growth Differentiation Factor 15 (GDF15) and Long-term Intraocular Pressure Fluctuation in Glaucoma: A Pilot Study. Lin JB, Sheybani A, Santeford A, Apte RS. J Ophthalmic Vis Res. 2021 Jan 20;16(1):21-27. doi: 10.18502/jovr.v16i1.8245. PMID: 33520124
Sourcing Photoreceptor-like Cells for Treating Vision Loss.
Increased Aqueous Humor GDF15 Is Associated with Worse Visual Field Loss in Pseudoexfoliative Glaucoma Patients. Transl Vis Sci Technol. 2020 Sep 15;9(10):16. doi: 10.1167/tvst.9.10.16. eCollection 2020 Sep. PMID: 3298362
Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration.
Retinal Biomarkers of Alzheimer Disease.
Anterior Chamber Angles after Intravitreal Injections for Macular Degeneration. Ophthalmol Retina. 2020 Jul;4(7):750-751. doi: 10.1016/j.oret.2020.02.007. Epub 2020 Feb 21. PMID: 32224100
Identification of Retinal Vascular Lesions Using Ultra-Widefield Angiography in Hereditary Hemorrhagic Telangiectasia Patients. Sindhar S, O’Bryhim BE, Licata J, Piccirillo JF, Apte RS. Ophthalmol Retina. 2019 Jun;3(6):510-515. doi: 10.1016/j.oret.2019.02.004. PMID: 31174673
SURGICAL OUTCOMES AFTER INVERTED INTERNAL LIMITING MEMBRANE FLAP VERSUS CONVENTIONAL PEELING FOR VERY LARGE MACULAR HOLES. Narayanan R, Singh SR, Taylor S, Berrocal MH, Chhablani J, Tyagi M, Ohno-Matsui K, Pappuru RR, Apte RS. Retina. 2019 Aug;39(8):1465-1469. doi: 10.1097/IAE.0000000000002186. PMID: 29689027
Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings. O’Bryhim BE, Apte RS, Kung N, Coble D, Van Stavern GP. JAMA Ophthalmol. 2018 Nov 1;136(11):1242-1248. doi:10.1001/jamaophthalmol.2018.3556. PMID: 30352114
Preoperative Electrophysiological Characterization of Patients with Primary Macula-involving Rhegmatogenous Retinal Detachment. Lin JB, Sein J, Van Stavern GP, Apte RS. J Ophthalmic Vis Res. 2018 Jul-Sep;13(3):241-248. doi: 10.4103/jovr.jovr_161_17. PMID: 30090179
Invited Reviews
NAD+ boosting brings tears to aging eyes. Yoshida, M., Apte, R.S. Nat Aging (2022). https://doi.org/10.1038/s43587-022-00172-5
Age-Related Macular Degeneration. Apte RS. N Engl J Med. 2021 Aug 5;385(6):539-547. doi: 10.1056/NEJMcp2102061. PMID: 34347954.
Practicality of Prophylactic Aflibercept to Reduce Diabetic Retinopathy Progression. Apte RS, Hwang CK. JAMA Ophthalmol. 2021 Jul 1;139(7):713-714. doi: 10.1001/jamaophthalmol.2021.0624. PMID: 33784736.
Seeing Parkinson Disease in the Retina. Lin JB, Apte RS. JAMA Ophthalmol. 2021 Feb 1;139(2):189-190. doi: 10.1001/jamaophthalmol.2020.5719. PMID: 33355611.
Sourcing Photoreceptor-like Cells for Treating Vision Loss. Apte RS. N Engl J Med. 2020 Nov 5;383(19):1888-1890. doi: 10.1056/NEJMcibr2027602. PMID: 33211935.
Retinal Biomarkers of Alzheimer Disease. Am J Ophthalmol. Lee CS, Apte RS. 2020 Oct;218:337-341. doi: 10.1016/j.ajo.2020.04.040. Epub 2020 May 6. PMID: 32387435; PMCID: PMC7529847.
Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration. Shah A, Apte RS. Trends Mol Med. 2020 Oct;26(10):892-895. doi: 10.1016/j.molmed.2020.08.003. Epub 2020 Aug 28. PMID: 32868169
Reducing Treatment Burden in AMD. Apte RS. Cell. 2020 Mar 19;180(6):1033. doi: 10.1016/j.cell.2020.02.028. PMID: 32200797; PMCID: PMC7460805.
Macrophage Plasticity and Function in the Eye and Heart. Wang Z, Koenig AL, Lavine KJ, Apte RS. Trends Immunol. 2019 Sep;40(9):825-841. doi: 10.1016/j.it.2019.07.002. Epub 2019 Aug 15. Review. PMID: 31422901
Challenges to Routine Genetic Testing for Inherited Rod Dystrophies. Li AS, MacKay D, Chen H, Rajagopal R, Apte RS. Ophthalmology. 2019 Apr 24. pii: S0161-6420(19)30766-3. doi:0.1016/j.ophtha.2019.04.031.PMID: 31028769
Visualizing the Heterogeneity of Retinal Microglia. Lin JB, Apte RS. Immunity. 2019 Mar 19;50(3):544-546. doi:10.1016/j.immuni.2019.02.017. PMID: 30893583
VEGF in Signaling and Disease: Beyond Discovery and Development. Apte RS, Chen DS, Ferrara N. Cell. 2019 Mar 7;176(6):1248-1264. doi:10.1016/j.cell.2019.01.021. PMID: 30849371
No Bad Blood: A Pars Plana Approach to Controlled Drainage of Suprachoroidal Hemorrhage. Li AS, Apte RS. Ophthalmol Retina. 2018 Oct;2(10):1082-1083. doi:0.1016/j.oret.2018.05.001. Epub 2018 Jun 7. PMID: 31047500
NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies. Lin JB, Apte RS. Prog Retin Eye Res. 2018 Nov;67:118-129. doi:10.1016/j.preteyeres.2018.06.002. Epub 2018 Jun 12. PMID: 29906612
Role of Sirtuins in Retinal Function Under Basal Conditions. Lin JB, Kubota S, Mostoslavsky R, Apte RS. Adv Exp Med Biol. 2018;1074:561-567. doi:10.1007/978-3-319-75402-4_68. PMID: 29721988
Inflammation-Induced Photoreceptor Cell Death. Sene A, Apte RS. Adv Exp Med Biol. 2018;1074:203-208. doi:10.1007/978-3-319-75402-4_25. Review. PMID: 29721945
Gene Therapy for Retinal Degeneration. Apte RS. Cell. 2018 Mar 22;173(1):5. doi: 10.1016/j.cell.2018.03.021. PMID: 29570997
Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Does Flavor Matter? Apte RS. JAMA Ophthalmol. 2018 Mar 1;136(3):269-270. doi:10.1001/jamaophthalmol.2017.6559. PMID: 29392302
Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications. Ban N, Siegfried CJ, Apte RS. Trends Mol Med. 2018 Jan;24(1):7-17. doi:10.1016/j.molmed.2017.11.004. Epub 2017 Dec 7. PMID: 29233479