Click here to view the full list of Dr. Rajendra S. Apte’s NCBI publications on PubMed

Fundamental Research 

EML1 is essential for retinal photoreceptor migration and survival. Poria D, Sun C, Santeford A, Kielar M, Apte RS, Kisselev OG, Chen S, Kefalov VJ. Sci Rep. 2022 Feb 21;12(1):2897. doi: 10.1038/s41598-022-06571-3. PMID: 35190581

Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages. Santeford A, Lee AY, Sene A, Hassman LM, Sergushichev AA, Loginicheva E, Artyomov MN, Ruzycki PA, Apte RS. Elife. 2021 Aug 23;10:e66703. doi: 10.7554/eLife.66703. Online ahead of print. PMID: 34423778 

HSV-1 and Zika but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon. Miner JJ, Plat DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA, Apte RS. Cell Rep. 2020 Nov 3;33(5)e108339. dio:10.1016/j.celrep.2020.108339. PMID33147451

SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration. Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N, Dong Z, Lin JB, Boye SL, DiAntonio A, Boye SE, Apte RS, Milbrandt J. Elife. 2020 Oct 27;9:e62027. doi: 10.7554/eLife.62027. PMID:33107823

LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G.JCI Insight. 2020 Jan 16;5(1):e131928. doi: 10.1172/jci.insight.131928. PMID31829999

FGF2-induced STAT3 activation regulates pathologic neovascularization. Dong Z, Santeford A, Ban N, Lee TJ, Smith C, Ornitz DM, Apte RSExp Eye Res. 2019 Aug 23;187:107775. doi: 10.1016/j.exer.2019.107775. PMID: 31449793

Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Yoshida M, Satoh A, Lin JB, Mills KF, Sasaki Y, Rensing N, Wong M, Apte RS, Imai SI. Cell Metab. 2019 Jun 7. pii: S1550-4131(19)30255-4. doi:0.1016/j.cmet.2019.05.015.  PMID: 31204283

Combined SIRT3 and SIRT5 deletion is associated with inner retinal dysfunction in a mouse model of type 1 diabetes. Lin JB, Lin JB, Chen HC, Chen T, Apte RS. Sci Rep. 2019 Mar 7;9(1):3799. doi:10.1038/s41598-019-40177-6. PMID: 30846716

Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. Ban N, Lee TJ, Sene A, Choudhary M, Lekwuwa M, Dong Z, Santeford A, Lin JB, Malek G, Ory DS, Apte RS. JCI Insight. 2018 Sep 6;3(17). pii: 120824. doi:10.1172/jci.insight.120824. eCollection 2018 Sep 6. PMID: 30185655

Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. Ban N, Lee TJ, Sene A, Dong Z, Santeford A, Lin JB, Ory DS, Apte RSJ Lipid Res. 2018 Aug;59(8):1414-1423. doi: 10.1194/jlr.M084442. Epub 2018 Jun 26. PMID: 29946056

Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging. Lin JB, Sene A, Santeford A, Fujiwara H, Sidhu R, Ligon MM, Shankar VA, Ban N, Mysorekar IU, Ory DS, Apte RS. EBioMedicine. 2018 Jun;32:9-20. doi: 10.1016/j.ebiom.2018.05.035. Epub 2018 Jun 11.  PMID: 29903570

WNT7A/B promote choroidal neovascularization. Lin JB, Sene A, Wiley LA, Santeford A, Nudleman E, Nakamura R, Lin JB, Moolani HV, Apte RS. Exp Eye Res. 2018 Sep;174:107-112. doi: 10.1016/j.exer.2018.05.033. Epub 2018 Jun 1. PMID: 29864439

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN. Nature. 2018 Apr;556(7702):501-504. doi: 10.1038/s41586-018-0052-z. Epub 2018 Apr 18. PMID: 29670287

NAD+-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism. Porter LC, Franczyk MP, Pietka T, Yamaguchi S, Lin JB, Sasaki Y, Verdin E, Apte RS, Yoshino J. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E520-E530. doi: 10.1152/ajpendo.00057.2018. Epub 2018 Apr 10. PMID: 29634313

Macrophage microRNA-150 promotes pathological angiogenesis as seen in age-related macular degeneration. Lin JB, Moolani HV, Sene A, Sidhu R, Kell P, Lin JB, Dong Z, Ban N, Ory DS, Apte RSJCI Insight. 2018 Apr 5;3(7). pii: 120157. doi: 10.1172/jci.insight.120157. eCollection 2018 Apr 5. PMID: 29618664

Translational Research 

Vitreous microparticles contain apoptotic signals suggesting a diabetic vitreopathy. Sultan H, Rajagopal R, Rao PK, Piggott KD, Paley MA, Hassman LM, Li AS, Marshall B, Apte RS. Int J Ophthalmol. 2022 Jan 18;15(1):89-97. doi: 10.18240/ijo.2022.01.14. PMID: 35047362; PMCID: PMC8720341.

Dexamethasone implant improves anatomic response to anti-VEGF therapy in treatment-resistant polypoidal choroidal vasculopathy. Mallikarjun K, Narayanan R, Raman R, Mohamed A, Shanmugam MP, Apte RS, Padhy SK. Int Ophthalmol. 2021 Nov 9. doi: 10.1007/s10792-021-02113-4. Epub 2021 Nov 9. PMID: 34755239.

New-Onset Macular Schisis in a Patient With Glaucoma. Wilke GA, O’Bryhim BE, Apte RS.  JAMA Ophthalmol. 2021;139(11):1236–1237. doi:10.1001/jamaophthalmol.2021.0939. PMID: 34473207.

OCT Angiography Findings in Preclinical Alzheimer’s Disease: 3-Year Follow-Up. O’Bryhim BE, Lin JB, Van Stavern GP, Apte RS. Ophthalmology. 2021 Oct;128(10):1489-1491. doi: 10.1016/j.ophtha.2021.02.016. Epub 2021 Feb 19. PMID: 33610626.

OCTA Findings in Pre-Clinical Alzheimer’s Disease: 3 Year Follow-Up. O’Bryhim BE, Lin JB, Van Stavern GP, Apte RS. Ophthalmology. 2021 Feb 18:S0161-6420(21)00128-7. doi: 10.1016/j.ophtha.2021.02.016. Epub ahead of print. PMID: 33610626

Longitudinal Growth Differentiation Factor 15 (GDF15) and Long-term Intraocular Pressure Fluctuation in Glaucoma: A Pilot Study. Lin JB, Sheybani A, Santeford A, Apte RS. J Ophthalmic Vis Res. 2021 Jan 20;16(1):21-27. doi: 10.18502/jovr.v16i1.8245. PMID: 33520124

Sourcing Photoreceptor-like Cells for Treating Vision Loss.  Apte RS. N Engl J Med. 2020 Nov 5;383(19):1888-1890. doi: 10.1056/NEJMcibr2027602. PMID: 33211935

Increased Aqueous Humor GDF15 Is Associated with Worse Visual Field Loss in Pseudoexfoliative Glaucoma Patients. Lin JB, Sheybani A, Santeford A, De Maria A, Apte RS. Transl Vis Sci Technol. 2020 Sep 15;9(10):16. doi: 10.1167/tvst.9.10.16. eCollection 2020 Sep. PMID: 3298362

Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration. Shah A, Apte RS. Trends Mol Med. 2020 Oct;26(10):892-895. doi: 10.1016/j.molmed.2020.08.003. Epub 2020 Aug 28. PMID: 32868169

Retinal Biomarkers of Alzheimer Disease. Lee CS, Apte RS. Am J Ophthalmol. 2020 Oct;218:337-341. doi: 10.1016/j.ajo.2020.04.040. Epub 2020 May 6. PMID32387435

Anterior Chamber Angles after Intravitreal Injections for Macular Degeneration. O’Bryhim BE, Lin JB, Piggott KD, Rao PK, Apte RS. Ophthalmol Retina. 2020 Jul;4(7):750-751. doi: 10.1016/j.oret.2020.02.007. Epub 2020 Feb 21. PMID: 32224100

Identification of Retinal Vascular Lesions Using Ultra-Widefield Angiography in Hereditary Hemorrhagic Telangiectasia Patients. Sindhar S, O’Bryhim BE, Licata J, Piccirillo JF, Apte RS. Ophthalmol Retina. 2019 Jun;3(6):510-515. doi: 10.1016/j.oret.2019.02.004.  PMID: 31174673

SURGICAL OUTCOMES AFTER INVERTED INTERNAL LIMITING MEMBRANE FLAP VERSUS CONVENTIONAL PEELING FOR VERY LARGE MACULAR HOLES. Narayanan R, Singh SR, Taylor S, Berrocal MH, Chhablani J, Tyagi M, Ohno-Matsui K, Pappuru RR, Apte RS. Retina. 2019 Aug;39(8):1465-1469. doi: 10.1097/IAE.0000000000002186. PMID: 29689027

Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings. O’Bryhim BE, Apte RS, Kung N, Coble D, Van Stavern GP. JAMA Ophthalmol. 2018 Nov 1;136(11):1242-1248. doi:10.1001/jamaophthalmol.2018.3556. PMID: 30352114

Preoperative Electrophysiological Characterization of Patients with Primary Macula-involving Rhegmatogenous Retinal Detachment. Lin JB, Sein J, Van Stavern GP, Apte RSJ Ophthalmic Vis Res. 2018 Jul-Sep;13(3):241-248. doi: 10.4103/jovr.jovr_161_17. PMID: 30090179

Invited Reviews

NAD+ boosting brings tears to aging eyes. Yoshida, M., Apte, R.S. Nat Aging (2022).

Age-Related Macular Degeneration. Apte RS. N Engl J Med. 2021 Aug 5;385(6):539-547. doi: 10.1056/NEJMcp2102061. PMID: 34347954.

Practicality of Prophylactic Aflibercept to Reduce Diabetic Retinopathy Progression. Apte RS, Hwang CK. JAMA Ophthalmol. 2021 Jul 1;139(7):713-714. doi: 10.1001/jamaophthalmol.2021.0624. PMID: 33784736.

Seeing Parkinson Disease in the Retina. Lin JB, Apte RS. JAMA Ophthalmol. 2021 Feb 1;139(2):189-190. doi: 10.1001/jamaophthalmol.2020.5719. PMID: 33355611.

Sourcing Photoreceptor-like Cells for Treating Vision Loss. Apte RS. N Engl J Med. 2020 Nov 5;383(19):1888-1890. doi: 10.1056/NEJMcibr2027602. PMID: 33211935.

Retinal Biomarkers of Alzheimer Disease. Am J Ophthalmol. Lee CS, Apte RS. 2020 Oct;218:337-341. doi: 10.1016/j.ajo.2020.04.040. Epub 2020 May 6. PMID: 32387435; PMCID: PMC7529847.

Optical Coherence Tomography Angiography: A Window into Central Nervous System Neurodegeneration. Shah A, Apte RS. Trends Mol Med. 2020 Oct;26(10):892-895. doi: 10.1016/j.molmed.2020.08.003. Epub 2020 Aug 28. PMID: 32868169

Reducing Treatment Burden in AMD. Apte RS. Cell. 2020 Mar 19;180(6):1033. doi: 10.1016/j.cell.2020.02.028. PMID: 32200797; PMCID: PMC7460805.

Macrophage Plasticity and Function in the Eye and HeartWang Z, Koenig AL, Lavine KJ, Apte RS. Trends Immunol. 2019 Sep;40(9):825-841. doi: 10.1016/ Epub 2019 Aug 15. Review. PMID: 31422901

Challenges to Routine Genetic Testing for Inherited Rod Dystrophies. Li AS, MacKay D, Chen H, Rajagopal R, Apte RS. Ophthalmology. 2019 Apr 24. pii: S0161-6420(19)30766-3. doi:0.1016/j.ophtha.2019.04.031.PMID: 31028769

Visualizing the Heterogeneity of Retinal Microglia. Lin JB, Apte RS. Immunity. 2019 Mar 19;50(3):544-546. doi:10.1016/j.immuni.2019.02.017. PMID: 30893583

VEGF in Signaling and Disease: Beyond Discovery and Development. Apte RS, Chen DS, Ferrara N. Cell. 2019 Mar 7;176(6):1248-1264. doi:10.1016/j.cell.2019.01.021. PMID: 30849371

No Bad Blood: A Pars Plana Approach to Controlled Drainage of Suprachoroidal Hemorrhage. Li AS, Apte RS. Ophthalmol Retina. 2018 Oct;2(10):1082-1083. doi:0.1016/j.oret.2018.05.001. Epub 2018 Jun 7. PMID: 31047500

NAD+ and sirtuins in retinal degenerative diseases: A look at future therapies. Lin JB, Apte RS. Prog Retin Eye Res. 2018 Nov;67:118-129. doi:10.1016/j.preteyeres.2018.06.002. Epub 2018 Jun 12. PMID: 29906612

Role of Sirtuins in Retinal Function Under Basal Conditions. Lin JB, Kubota S, Mostoslavsky R, Apte RS. Adv Exp Med Biol. 2018;1074:561-567. doi:10.1007/978-3-319-75402-4_68. PMID: 29721988

Inflammation-Induced Photoreceptor Cell Death. Sene A, Apte RS. Adv Exp Med Biol. 2018;1074:203-208. doi:10.1007/978-3-319-75402-4_25. Review. PMID: 29721945

Gene Therapy for Retinal Degeneration. Apte RS. Cell. 2018 Mar 22;173(1):5. doi: 10.1016/j.cell.2018.03.021. PMID: 29570997

Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Does Flavor Matter? Apte RS. JAMA Ophthalmol. 2018 Mar 1;136(3):269-270. doi:10.1001/jamaophthalmol.2017.6559. PMID: 29392302

Monitoring Neurodegeneration in Glaucoma: Therapeutic Implications. Ban N, Siegfried CJ, Apte RS. Trends Mol Med. 2018 Jan;24(1):7-17. doi:10.1016/j.molmed.2017.11.004. Epub 2017 Dec 7. PMID: 29233479