Research Interests
- The role of the innate immune system in regulating pathologic angiogenesis
- The effects of senescence on macrophage gene regulation
- Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration
- Regulation of photoreceptor cell death by inflammation
- The role of innate immune cells in aging and disease
Lab News
12/15/2020: Welcome to the Apte Lab, Dr. Ryo Terao!
11/30/2020: Christopher K. Wang, MD PhD, receives Vitreoretinal Surgery Foundation (VRSF) research grant
11/22/2020: Congratulations, Harsh Moolani, Rhodes finalist!
11/5/2020: Sourcing Photoreceptor-like Cells for Treating Vision Loss
11/3/2020: Cornea appears to resist infection from novel coronavirus
10/29/2020: SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
Current Projects:
- Investigating the mechanisms underlying photoreceptor cell death in models of retinal disease
- Investigating the role of the innate immune system in regulating angiogenesis
- Analyzing gene expression of the macrophage transcriptome and the effects of aging
- Examining the mechanisms responsible for changes in macrophage cell metabolism that may contribute to blinding diseases of the eye
- Using tissue specific deletion of soluble and membrane expressed molecular activators of myeloid cell function in order to define the role of these cells in regulating post-developmental angiogenesis and retinal photoreceptor cell demise
- Studying the role of senescence and physiologic aging and their contribution to age-associated eye diseases