Research Interests
- The role of the innate immune system in regulating pathologic angiogenesis
- The effects of senescence on macrophage gene regulation
- Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration
- Regulation of photoreceptor cell death by inflammation
- The role of innate immune cells in aging and disease
- Molecular regulation of uveitis
Lab News
5/19/2021: Congratulations, Dr. Mitsu Yoshida, Washington University School of Medicine graduate!
5/5/2021: Ryo Terao, MD PhD has been selected as the 2021 International Retinal Research Foundation Alston Callahan, MD Postdoctoral Scholar
4/1/2021: Welcome to the Apte Lab, Dr. Keitaro Hase!
3/22/2021: Dr. Apte appointed Associate Editor to Ophthalmology Science Journal
3/19/2021: Ryo Terao, MD PhD has received a grant from Bayer Japan for retinal research
Current Projects:
- Investigating the mechanisms underlying photoreceptor cell death in models of retinal disease
- Investigating the role of the innate immune system in regulating angiogenesis
- Analyzing gene expression of the macrophage transcriptome and the effects of aging
- Examining the mechanisms responsible for changes in macrophage cell metabolism that may contribute to blinding diseases of the eye
- Using tissue specific deletion of soluble and membrane expressed molecular activators of myeloid cell function in order to define the role of these cells in regulating post-developmental angiogenesis and retinal photoreceptor cell demise
- Studying the role of senescence and physiologic aging and their contribution to age-associated eye diseases