Research Interests



  • The role of the innate immune system in regulating pathologic angiogenesis
  • The effects of senescence on macrophage gene regulation
  • Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration
  • Regulation of photoreceptor cell death by inflammation
  • The role of innate immune cells in aging and disease
  • Molecular regulation of uveitis
  • The role of microRNAs in aging and age-related eye pathologies
  • Molecular mechanisms in retinal microglia contributing to eye pathologies
  • Contributions of immune cells in




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Lab News

12/2/2021: Congratulations, Chas Pfeiffer, DBBS graduation student! Chas has been awarded a grant from the VitreoRetinal Surgery Foundation (VRSF) to support his research.

11/11/2021: Congratulations, Keitaro Hase MD PhD, on the arrival of his first daughter.

11/9/2021: New publication “Dexamethasone implant improves anatomic response to anti-VEGF therapy in treatment-resistant polypoidal choroidal vasculopathy” is now available in International Ophthalmology.

11/1/2021: New publication “New-Onset Macular Schisis in a Patient With Glaucoma” is now available in JAMA Ophthalmology.

10/30/2021: Congratulations, Zelun Wang (MSTP), for winning first prize for his poster presentation at the inaugural DOVS research retreat.

 

Current Projects:

  • Investigating the mechanisms underlying photoreceptor cell death in models of retinal disease
  • Investigating the role of the innate immune system in regulating angiogenesis
  • Analyzing the macrophage transcriptome and its effects on aging
  • Examining the mechanisms responsible for changes in macrophage cell metabolism that may contribute to blinding diseases of the eye
  • Using tissue specific deletion of soluble and membrane expressed molecular activators of myeloid cell function in order to define the role of these cells in regulating post-developmental angiogenesis and retinal photoreceptor cell demise
  • Elucidating the role of resident microglia in retinal pathologies
  • Examining circadian rhythm in retinal immune cells
  • Studying the role of senescence and physiologic aging and their contribution to age-associated eye diseases