Research Interests

  • The role of the innate immune system in regulating pathologic angiogenesis
  • The effects of senescence and physiologic aging on macrophage gene regulation
  • Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration
  • Regulation of photoreceptor cell death by inflammation
  • The role of innate immune cells in aging and disease
  • Molecular regulation of uveitis
  • The role of microRNAs in aging and age-related eye pathologies
  • Molecular mechanisms in retinal microglia contributing to eye pathologies
  • The role of cholesterol transport in models of ocular disease
  • Therapeutic interventions for dry eye disease

Lab News

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4-17-2024: New publication in Cell Reports from lead author Ryo Terao, MD, PhD, “LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion.

4-11-24: Chas Pfeiffer, PhD, has been awarded the 2024 Dr. Philip Needleman Pharmacology Award

4-5-24: Joseph Lin, MSTP, was awarded a Mark S. Wrighton Research Award on Aging at the 23rd annual Friedman Lecture and Awards at the Harvey A. Friedman Center for Aging at the Institute for Public Health at Washington University.  This award recognizes doctoral students for outstanding research in age-related topics.  Congratulations, Joseph!

4-2-24: Welcome staff scientist Shuntaro Ogura, PhD!

4-1-24: Congratulations to Zelun Wang (MSTP) on the successful defense of his thesis, “Energetic Heterogeneity in Retinal Ganglion Cells: Role of Neuronal Activity and Implications for Resilience”

3-14-24: New review “Retinal Detachment” available now in Nature Reviews Disease Primers.