Research Interests:

  • The role of the innate immune system in regulating pathologic angiogenesis.
  • The effects of senescence on macrophage gene regulation.
  • Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration.
  • Regulation of photoreceptor cell death by inflammation.

Current Projects:

  • Investigating the mechanisms underlying photoreceptor cell death in models of retinal disease
  • Investigating the role of the innate immune system in regulating angiogenesis
  • Analyzing gene expression of the macrophage transcriptome and the effects of aging
  • Examining the mechanisms responsible for changes in macrophage cell metabolism that may contribute to blinding diseases of the eye
  • Using tissue specific deletion of soluble and membrane expressed molecular activators of myeloid cell function in order to define the role of these cells in regulating post-developmental angiogenesis and retinal photoreceptor cell demise
  • Studying the role of senescence and physiologic aging and their contribution to age-associated eye diseases