Research Interests

  • The role of the innate immune system in regulating pathologic angiogenesis
  • The effects of senescence on macrophage gene regulation
  • Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration
  • Regulation of photoreceptor cell death by inflammation
  • The role of innate immune cells in aging and disease

Lab News

12/15/2020: Welcome to the Apte Lab, Dr. Ryo Terao!

11/30/2020: Christopher K. Wang, MD PhD, receives Vitreoretinal Surgery Foundation (VRSF) research grant 

11/22/2020: Congratulations, Harsh Moolani, Rhodes finalist!

11/5/2020: Sourcing Photoreceptor-like Cells for Treating Vision Loss

11/3/2020: Cornea appears to resist infection from novel coronavirus 

10/29/2020: SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration                                                                  

Current Projects:

  • Investigating the mechanisms underlying photoreceptor cell death in models of retinal disease
  • Investigating the role of the innate immune system in regulating angiogenesis
  • Analyzing gene expression of the macrophage transcriptome and the effects of aging
  • Examining the mechanisms responsible for changes in macrophage cell metabolism that may contribute to blinding diseases of the eye
  • Using tissue specific deletion of soluble and membrane expressed molecular activators of myeloid cell function in order to define the role of these cells in regulating post-developmental angiogenesis and retinal photoreceptor cell demise
  • Studying the role of senescence and physiologic aging and their contribution to age-associated eye diseases