Research Interests

  • The role of the innate immune system in regulating pathologic angiogenesis
  • The effects of senescence on macrophage gene regulation
  • Oxidative stress, inflammation and the regulation of cell death in models of macular degeneration
  • Regulation of photoreceptor cell death by inflammation
  • The role of innate immune cells in aging and disease
  • Molecular regulation of uveitis

Lab News


5/19/2021: Congratulations, Dr. Mitsu Yoshida, Washington University School of Medicine graduate!

5/5/2021: Ryo Terao, MD PhD  has been selected as the 2021 International Retinal Research Foundation Alston Callahan, MD Postdoctoral Scholar

4/1/2021: Welcome to the Apte Lab, Dr. Keitaro Hase!

3/22/2021: Dr. Apte appointed Associate Editor to Ophthalmology Science Journal

3/19/2021: Ryo Terao, MD PhD has received a grant from Bayer Japan for retinal research

Current Projects:

  • Investigating the mechanisms underlying photoreceptor cell death in models of retinal disease
  • Investigating the role of the innate immune system in regulating angiogenesis
  • Analyzing gene expression of the macrophage transcriptome and the effects of aging
  • Examining the mechanisms responsible for changes in macrophage cell metabolism that may contribute to blinding diseases of the eye
  • Using tissue specific deletion of soluble and membrane expressed molecular activators of myeloid cell function in order to define the role of these cells in regulating post-developmental angiogenesis and retinal photoreceptor cell demise
  • Studying the role of senescence and physiologic aging and their contribution to age-associated eye diseases