Plastrik, A.R. and Zaher, H.S. (2024) “Not just a garbage truck, no-go decay plays a role during embryo development in zebrafish”. PLoS Biology. 22(12):e3002925(Preview/Primer).
Kim, K.Q., Li, J.J., Nanjaraj Urs, A.N., Pacheco, M.E., Lasehinde, V., Denk, T., Tesina, P., Tomomatsu, S., Matsuo, Y., McDonald, E., Beckmann, R., Inada, T., Green, R. and Zaher, H.S. (2024) “Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes”. Mol Cell. 84(23):4594-4611.
Zaher, H.S.* and Mosammaparast, N. (2024)“RNA damage responses in cellular homeostasis and genome stability”. Annual Review of Pathology: Mechanisms of Disease. doi: 10.1146/annurev-pathmechdis-111523-023516.
Nanjaraj Urs, A.N., Lasehinde, V., Kim, L., McDonald, E. Yan, L.L. and Zaher, H.S. (2024) “Inability to rescue stalled ribosomes results in overactivation of the integrated stress response”. J Biol Chem. 300(5):107290.
Kim, K.Q., Nanjaraj Urs, A.N., Lasehinde, V., Greenlaw, A.C., Hudson, B.H. and Zaher, H.S. (2024) “eIF4F complex dynamics are important for the activation of the integrated stress response”. Mol Cell. 84(11):2135-2151.
McGuffey J.C., Jackson-Litteken C.D., Di Venanzio G., Zimmer A.A., Lewis J.M., Distel J.S., Kim K.Q., Zaher H.S., Alfonzo J., Scott N.E., Feldman M.F. (2023) “The tRNA methyltransferase TrmB is critical for Acinetobacter baumannii stress responses and pulmonary infection”. mBio 14(5):e0141623
Crawford J.M., Yan L.L., Zaher H. and Hardy R.W. (2022) “Host-dependent modifications of packaged alphavirus genomic RNA influence virus replication in mammalian cells” Viruses 14(12):2606
43 Hilliard K.A., Throm A.A., Pingel J.T., Saucier N., Zaher H.S. and French AR (2022) “Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis” Front Immunol 13:1007022
Kim, K.Q. and Zaher, H.S. (2022) “Translating while under attack: Plant defense mRNAs find a way” Mol Cell. 82(17):3124-3125 (Preview)
Kim K.Q., Burgute B.D., Tzeng S.C., Jing C., Jungers C., Zhang J., Yan L.L.1, Vierstra R.D., Djuranovic S., Evans B.S. and Zaher, H.S. (2022) “N1-methylpseudouridine of COVID-19 mRNA vaccines produces faithful protein products” Cell Reports 40(9):111300
Bhattacharya, T., Yan, L., Zaher, H., Hardy, R. and Newton, I. (2022) “Differential methylation of viral RNA in the presence of Wolbachia pipientis contributes to pathogen blocking in arthropods” PLOS Pathogens 8: e1010393
Bonilla, B., Brown, A.J., Hengel, S.R., Rapchak, K.S., Mitchell, D., Pressimone, C.A., Fagunloye, A.A., Luong, T.T, Zaher, H., Mosammaparast, N., Malc, E.P., Mieczkowski, P.A., Roberts, S.A. and Bernstein, K.A. (2021) “The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific DNA alkylation lesions” eLife 10: e68080
Kim, K.Q. and Zaher, H.S. (2022) “Canary in a coal mine: collided ribosomes as sensors of cellular conditions” Trends Biochem. Sci. 47: 82-97 (Invited Review)
Encyclopedia of Biological Chemistry, 3rd Edition (2021) Jez JM, Ed.; Allewell N, Blankenship R, Chapman KD, Cooper AJL, Maresca TJ, Pandey S, Zaher H, Assoc. Eds. Elsevier, Oxford, UK (4822 pages)
Yan, L.L. and Zaher, H.S. (2021) “Ribosome-quality control antagonizes the activation of the integrated-stress response on colliding ribosomes” Mol. Cell81: 614-628
Thomas, E.N., Kim, K.Q. McHugh, E.P., Marcinkiewicz, T. and Zaher, H.S. (2020) “Alkylative damage of mRNA leads to ribosome stalling and rescue by trans-translation in bacteria” eLife, 9:e61984.
Verma, M.*, Junhong Choi, J.*, Cottrell, K.A.*, Lavagnino, Z., Thomas, E.N., Pavlovic-Djuranovic, S., Pawel Szczesny, P., Piston, D.W., Zaher, H.S., Puglisi, J.D. and Djuranovic, S. (2019) “Short translational ramp determines efficiency of protein synthesis” Nat Commun. 10(1):5774
Yan, L.L., Simms, C.L., McLoughlin, F., Vierstra, R.D. and Zaher, H.S. (2019) “Oxidation and alkylation stresses activate ribosome-quality control”. Nat Comm. 10(1):5611
Thomas E.N., Simms C.L., Keedy H.E. and Zaher H.S. (2019) “Insights into the base-pairing preferences of 8-oxoguanosine on the ribosome” Nucleic Acids Res, 47(18):9857-9870.
Yan, L.L. and Zaher H.S. (2019) “How do cells cope with RNA damage and its consequences?” J Biol Chem, 294(41):15158-15171. (Invited review).
Simms, C. L., Yan, L.L., Qiu, J. N., and Zaher H.S. (2019) “Ribosome Collisions Result in +1 Frameshifting in the Absence of No-Go Decay” Cell Rep 28(7):1679-1689.
Oliviera, V., Mahajan, N., Bates, M.L., Tripathi, C., Kim, K.Q., Zaher, H.S., Maggi, L. B. (Jr) and Tomasson, M.H. (2019) “The snoRNA target of t (4; 14) in multiple myeloma regulates ribosome biogenesis” FASEB BioAdvances 1(7):404-414.
Yan, L.L. and Zaher, H.S. (2019) “Ubiquitin is a beacon for all during quality control on the ribosome” EMBO J, 38(5). pii: e101633.
Simms, C.L., Kim, K.Q., Yan, L.L., Qiu, J. and Zaher H.S. (2018) “Interactions between the mRNA and Rps3/uS3 at the entry tunnel of the ribosomal small subunit are important for no-go decay” PLoS Genet., 14(11):e1007818.
Keedy, H.E. Thomas, E.N., and Zaher, H.S. (2018) “Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone” Proc Natl Acad Sci USA, 115(29):E6731-E6740
Simms, C. L., Yan, L.L. and Zaher H.S. (2017) “Ribosome collision is critical for quality control during no-go decay” Mol Cell, 68(2):361-373
Arefanian S., Schäll D., Chang S., Ghasemi R., Higashikubo R., Zheleznyak A., Guo Y., Yu J., Asgharian H., Li W., Gelman A.E., Kreisel D., French A.R., Zaher H., Plougastel-Douglas B., Maggi L., Yokoyama W., Beer-Hammer S., Krupnick A.S. (2016) “Deficiency of the adaptor protein SLy1 results in a natural killer cell ribosomopathy affecting tumor clearance”. Oncoimmunology, 5(12):e1238543.
Pierson, W.E., Hoffer, E., Keedy, H.E., Simms, C.L., Dunham, C.M. and Zaher H.S. (2016) “Uniformity of peptide release is maintained by methylation of release factors” Cell reports, 17(1):11-8
Simms, C.L., Thomas, E.N. and Zaher, H.S. (2016) “Ribosome-based Quality Control Mechanisms” Wiley Interdiscip Rev RNA. doi: 10.1002/wrna.1366 (Invited review).
Simms, C.L. and Zaher, H.S. (2016) “Quality control of chemically damaged RNA” Cellular and Molecular Life Sciences. 73(19):3639-53 (Invited review)
Carle, C.M., Zaher, H.S. and Chalker, D.L. (2016) “A parallel G quadruplex-binding protein regulates the boundaries of DNA elimination events of Tetrahymena thermophile” PLOS Genetics. 12(3):e1005842.
Hudson, B.H. and Zaher, H.S. (2015) “O6-Methylguanosine leads to position-dependent effects on ribosome speed and fidelity”. RNA, 21(9):1648-1659.
Djuranovic, S.D. and Zaher, H.S. (2015) “Targeted mRNA degradation” in Encyclopedia of Cell Biology, Hart, Goud, Raposo, Ezekowitz and Lauffenburger, eds (Elsevier, Oxford, UK). (Book chapter)
Simms, C.S., Hudson, B.H., Mosior, J.W., Rangwala A. S. and Zaher, H.S. (2014) “An active role for the ribosome in determining the fate of oxidized mRNA”. Cell reports, 9(4):1256-1264.
Hudson, B.H. and Zaher, H.S. (2014) “Ribosomes left in the dust: diverse strategies for peptide-mediated translation stalling”. Mol. Cell. 56(3):345-346.
Petropoulos, A. D., McDonald, M. E., Green, R. and Zaher, H. S. (2014) “Distinct roles for release factor 1 and release factor 2 in translational quality control”. J. Biol. Chem., 289(25):17589-96.
Zaher, H. S. and Green, R. (2014) “In vitro synthesis of proteins in bacterial extracts”. Methods Enzymol. 539:3-15.
Zaher, H. S. and Green, R. (2011) “A primary role for release factor 3 in quality control during translation elongation in Escherichia coli”. Cell, 147(2):396-408.
Miller, M. R., Liu, Z., Cazier, D. J., Gebhard, G. M., Herron, S. R., Zaher, H. S., Green, R. and Buskirk, A. R. (2011) “The role of SmpB and the ribosomal decoding center in licensing tmRNA entry into stalled ribosomes”. RNA, 17(9):1727-36.
Zaher, H. S., Shaw, J. J., Strobel, S. A. and Green, R. (2011) “The 2′-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC”. EMBO J, 30(12):2445-53.
Ortiz-Meoz, R. F., He, S. L., Zaher, H. S. and Green, R. (2011) “Sense and nonsense recognition by the ribosome” in Ribosomes Structure, Function, and Dynamics, Rodnina, M. V.; Wintermeyer, W.; Green, R., eds. (Springer-Verlag, New York). (Book Chapter)
Zaher, H. S. and Green, R. (2010) “Kinetic basis for global loss of fidelity arising from mismatches in the P-site codon:anticodon helix”. RNA, 16(10):1980-9.
Zaher, H.S. and Green, R. (2010) “Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRNA selection”. Molecular Cell, 39(1):110-20.
Zaher, H. S. and Green, R. (2009) “Quality control on the ribosome following peptide bond formation”. Nature, 457(7226): 161-166.
Zaher, H. S. and Green, R. (2009) “Fidelity at the molecular level: lessons from protein synthesis”. Cell, 136(4): 746-762. (Review)
Zaher, H. S. and Unrau, P. J. (2007) “Selection of an improved RNA polymerase ribozyme with superior extension and fidelity”. RNA, 13(7):1017-26.
Zaher, H. S. and Unrau, P. J. (2006) “A general RNA-capping ribozyme retains stereochemistry during cap exchange”. JACS, 128(42):13894-900.
Zaher, H. S., Watkins, R. A. and Unrau, P. J. (2006) “Two distinct capping ribozymes have highly convergent catalytic properties”. RNA, 12(11):1949-58.
Zaher, H. S. and Unrau, P. J. (2005) “Nucleic acid library construction using synthetic DNA constructs”. Methods Mol Biol. 288: 359-378. (Book Chapter)
Zaher, H. S. and Unrau, P. J. (2004) “T7 RNA polymerase mediates fast promoter-independent extension of unstable nucleic complexes.” Biochemistry 43(24): 7873-7880.