The translation of the genetic code into functional protein sequences is a feat accomplished in all domains of life by the ribosome. Protein synthesis is a complex multistep process that can be divided into three main phases: initiation, elongation and termination.
During each cycle of elongation, the two-subunit macromolecular machine decodes the mRNA transcripts by carefully selecting the appropriate aminoacyl-tRNA (aa-tRNA) that matches the mRNA codon in the decoding center from a large pool of competing aa-tRNAs.
The long term goal of the Zaher lab is to expand the understanding of the mechanisms that govern translational fidelity as well as learn about their impact on cellular fitness and codon evolution.
Seeking to avoid ‘full lockdown,’ cells monitor ribosome collisions: Cells activate individual quality control responses if they can (Links to an external site)
Zaher Lab receives NIH grant
Hani promoted to Associate Professor
Department of Biology
Washington University in St. Louis
Campus Box 1137
One Brookings Dr
St. Louis, MO, 63130
For parcels, please use the following address:
1 Brookings Dr – Biology Dept
133 Rebstock Hall
St. Louis, MO 63130-4899
The Zaher lab is located in Bayer Lab 506 at the Danforth Campus of Washington University in St. Louis.