Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel.
. Nature Communications 13:6904 (2022).
Structure of the Wilson disease copper transporter ATP7B.
. Science Advances 8:eabl5508 (2022).
Connecting copper and cancer: from transition metal signalling to metalloplasia.
Ge EJ et al. Nature Reviews Cancer (2021). https://doi.org/10.1038/s41568-021-00417-2
High-affinity copper transporter Ctr1.
Yuan P. Encyclopedia of Inorganic and Bioinorganic Chemistry (2021). https://doi.org/10.1002/9781119951438.eibc2778
Cryo-EM structure of a proton-activated chloride channel TMEM206.
, , , , , ,, , Yuan P. Science Advances 7:eabe5983 (2021).
Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance.
Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P. Nature Communications 11: 3690 (2020).
Gating of human TRPV3 in a lipid bilayer.
Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P. Nature Structural & Molecular Biology 27: 635-644 (2020).
Coupling of Ca2+ and voltage activation in BK channels through the αB helix/voltage sensor interface.
Geng Y,Deng Z, Zhang G, Budelli G, Butler A, Yuan P, Cui J, Salkoff L, Magleby KL. Proceedings of the National Academy of Sciences of the United States of America 117: 14512-14521 (2020).
Cryo-EM structures of the ATP release channel pannexin 1.
Deng Z, He Z, Maksaev G, Bitter RM, Rau M, Fitzpatrick JAJ, Yuan P. Nature Structural & Molecular Biology 27: 373-381(2020).
Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.
Zangerl-Plessl EM, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P, Stary-Weinzinger A, Nichols CG. Journal of General Physiology 152: e201912422 (2020).
Structural biology of thermoTRPV channels.
Yuan P. Cell Calcium 84: 102106 (2019).
X-ray structures of the high-affinity copper transporter Ctr1.
Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P. Nature Communications 10: 1386 (2019).
Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.
Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ. Nature Microbiology 3: 1362-1368 (2018).
Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms.
Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P. Nature Structural & Molecular Biology 25: 252-260 (2018).
A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities.
Geng Y, Ferreira JJ, Dzikunu V, Butler A, Lybaert P, Yuan P, Magleby KL, Salkoff L, Santi CM. Journal of Biological Chemistry 292:8978-8987 (2017).
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.
Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG. Journal of General Physiology 148: 227-237 (2016).
Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel.
Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R. Nature 527: 198-203 (2015).
Attachment site recognition and regulation of directionality by the serine integrases.
Rutherford K, Yuan P, Perry K, Sharp R, Van Duyne GD. Nucleic Acids Research 41:8341-8356. (2013).
Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Leonetti MD, Yuan P, Hsiung Y, MacKinnon R. Proceedings of the National Academy of Sciences of the United States of America 109: 19274-19279 (2012).
Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.
Yuan P, Leonetti MD, Hsiung Y, MacKinnon R. Nature 481: 94-97 (2012).
Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution.
Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R. Science 329: 182-186 (2010).
