Actively-enrolling studies



Biomarkers of Alzheimer Disease in Sleep and EEG

The goal of this study is to develop sleep and EEG (brain wave) biomarkers of early Alzheimer Disease, to use for non-invasive screening, even prior to cognitive symptoms.

We are actively enrolling participants at least 65 years of age, who have normal memory or mild problems with memory. The study involves memory tests, sleep studies at home and at the Washington University medical campus, and a lumbar puncture. Participants will be reimbursed for their time and effort.

[In collaboration with Miranda Lim MD PhD]

NAPS Consortium

NAPS Consortium

North American Prodromal Synucleinopathy Consortium for REM sleep behavior disorder

The NAPS Consortium is enrolling participants with REM sleep behavior disorder (RBD), in order to form a trial-ready cohort for future neuroprotective treatment clinical trials. Washington University is the lead site for the 10 NAPS Consortium sites in the US and Canada. Please visit the NAPS Consortium website for additional details.

Sleep and Circadian Rhythms in Alzheimer Disease

Sleep and Circadian Rhythms in Alzheimer Disease

“Sleep & Tau” study

There is a bi-directional relationship between sleep/circadian dysfunction and Alzheimer Disease pathology. In this study, we will tease apart this chicken-and-egg relationship by re-measuring sleep in individuals who participated in the Knight ADRC Actigraphy Wave 1 study in 2010-2012. Contact or call us if you are interested in participating.

[In collaboration with David Holtzman MD, Erik Musiek MD PhD]

Completed studies

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Sleep and Amyloid

Targeting slow wave sleep to control neuronal activity and amyloid-beta dynamics

This study showed that

  1. Obstructive sleep apnea appears to reduce clearance of brain waste products including amyloid-beta,
  2. Treatment of obstructive sleep apnea seems to normalize the relationship between amyloid-beta and sleep quality, and
  3. Slow wave sleep disruption specifically results in an increase in amyloid-beta levels in the cerebrospinal fluid.

This study has completed enrollment, but CSF, polysomnography, EEG, and other data and biospecimens are available for further analysis.

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KADRC Actigraphy Wave 1

Original 2010-2012 cohort

205 cognitively-normal participants from the Knight Alzheimer Disease Research Center had actigraphy measurement of their sleep and circadian rhythms. This study was the first to show that individuals with preclinical Alzheimer Disease (brain changes but without cognitive symptoms) have worse sleep quality as well as irregular circadian activity rhythms.

[In collaboration with David Holtzman MD]


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OSA and Glucose Metabolism

PI Bettina Mittendorfer PhD

This study uses deep metabolic phenotyping to determine tissues and mechanisms responsible for abnormal glucose metabolism in individuals with obstructive sleep apnea.

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Postoperative Delirium and Electroencephalographic Measures of Sleep and Wakefulness

PI Ben Palanca MD PhD

This study examines sleep EEG predictors of delirium in the postoperative period.

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Sleep Apnea and FEtal growth Restriction

PI Ellen Lockhart MD

This study will assess the effect of obstructive sleep apnea in pregnant women on fetal growth restriction.

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Perioperative Delirium

CPAP adherence and postoperative delirium in patients with OSA

PI Michael Avidan MBBCh FCA SA

This study examined the effect of obstructive sleep apnea and its treatment with CPAP on postoperative delirium.

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Systemic Lupus Erythematosus Evaluation of Poor Sleep

PI Alfred Kim MD PhD

SLEEPS is a prospective, longitudinal, observational cohort enrolling patients with Lupus followed at the Lupus Clinic at Washington University.

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March of Dimes Prematurity Center

Theme 3: The Influence of Chronotype on Risk of Preterm Birth

Theme 3 Leaders: Sarah England PhD, Erik Herzog PhD, Emily Jungheim MD MSCI, Justin Fay

Does the disruption of maternal sleep/wake patterns contribute to preterm birth?