The Genome Engineering Core (GEC Directors: Dr. Farshid Guilak and Dr. Megan Cooper). The GEC has two units: a) the Genome Engineering and iPSC Center (GEiC directed by Dr. Xiaoxia Cui) and b) the Transgenic and Knockout Mouse Facility (TKMF headed by Mr. Mike White).
- The GEiC offers a wide range of services including CRISPR nuclease design, assembly and validation for generation of genetically modified mouse models. A comprehensive list of services at GEiC is available at http://geic.wustl.edu/. The GEC will facilitate use of GEiC by as many members as possible but will prioritize use by junior faculty (Instructors, Assistant Professors). The GEC will reimburse 50% costs for autoimmune- and rheumatic disease-related projects (up to $4,000 for junior faculty and $1,000 for other members). Submissions are o a rolling basis and can be directed to Dr. Megan Cooper.
- The TKMF works closely with the GEiC for the rapid generation of genetically-modified mice. Other services offered by the TKMF are available at https://pathology.wustl.edu/research/corefacilities/transgenic-knockout-micro-injection-core/. All WU-RDRRC members receive subsidized services when using the TKMF.