Publications | The Moeller Research Group | Washington University in St. Louis

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Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites

Yu-Chia Chang, Benoit Arnould, Jennifer M. Heemstra and Kevin D. Moeller*

Microelectrode Arrays, Electrocatalysis, and the Need for Proper Characterization

Albert Huang, Ruby Krueger, Kevin D Moeller

Publication Date: Nov 17, 2023

Anodic Cyclizations, Densely Functionalized Synthetic Building Blocks, and the Importance of Recent Mechanistic Observations

Ruby Krueger, Enqi Feng, Polina Barzova, Noah Lieberman, Song Lin, Kevin D. Moeller*

Anodic Cyclizations and Umpolung Reactions Involving Imines

Zach Medcalf, Essence G. Redd, Jaemyeong Oh, Chang Ji*, and Kevin D. Moeller*

Publication Date:May 30, 2023

A Building Block Approach for the Total Synthesis of YM-385781

Yu Zhu, Siyue Liu, Johnny Zigmond, Kevin M. Kaltenbronn, Kendall J. Blumer, Kevin David Moeller

Publication date : 25 April 2023

Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface

Kendra Drayton-White‡, Siyue Liu‡, Yu-Chia Chang, Sakashi Uppal and Kevin D. Moeller*

Publish date: 20 Oct 2022

Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability

Matthew R. Medcalf , Ruby L. Krueger , Zach T. Medcalf , Peter A. Rosston , Yu Zhu , Kevin M. Kaltenbronn , Kendall J. Blumer∗ , Kevin D. Moeller∗

Publication date: 10 June 2022

15 Paired Electrolysis

Wu, T.; Moeller, K. D., Science of Synthesis: Electrochemistry in Organic Synthesis, (2021) 1, 481.

Lessons from an Array: Using an Electrode Surface to Control the Selectivity of a Solution-Phase Chemical Reaction

The confinement of a preparative reaction to the surface of an electrode offers new opportunities to induce selectivity into the transformation.

Enqi Feng, Qiwei Jing, Kevin D. Moeller*

Publication Date: 04 January 2022

Electrochemistry in Synthetic Organic Chemistry

Hai-Chao Xu* and Kevin D. Moeller*

Publication Date:November 19, 2021

Capitalizing on Mediated Electrolyses for the Construction of Complex, Addressable Molecular Surfaces

Ruby Krueger and Kevin D. Moeller*

Publication Date:October 7, 2021

Anodic Olefin Coupling Reactions: Elucidating Radical Cation Mechanisms and the Interplay between Cyclization and Second Oxidation Steps

Zach Medcalf, Kevin D. Moeller*

Publication Date: June 11, 2021

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Tiandi Wu, Kevin D. Moeller*

Publication Date: March 26, 2021

Using a Combination of Electrochemical and Photoelectron Transfer Reactions to Gain New Insights into Oxidative Cyclization Reactions

Matthew D. Graaf, Luisalberto Gonzalez, Zach Medcalf and Kevin D. Moeller*

Publication Date: October 12, 2020

Electrons, Electrodes, and the Transformation of Organic Molecules

Robert Francke, Luisalberto Gonzalez, R. Daniel Little, Kevin D. Moeller*

Publication Date: January 17, 2020

From Molecules to Molecular Surfaces. Exploiting the Interplay Between Organic Synthesis and Electrochemistry

Qiwei Jing and Kevin D. Moeller*

Publication Date:December 31, 2019

Electroorganic Synthesis and the Construction of Addressable Molecular Surfaces

Nai-Hua Yeh, Yu Zhu, and Kevin D. Moeller*, ChemElectroChem 2019, 6, pp 4134-4143

Anodic Cyclizations, Seven-Membered Rings, and the Choice of Radical Cation vs. Radical Pathways

Robert J. Perkins, Ruozhu Feng, Qingquan Lu, and Kevin D. Moeller*

Chin. J. Chem. 2019, 37, pp 672－678

Paired Electrochemical Reactions and the On‐Site Generation of a Chemical Reagent

Tiandi Wu; Bichlien H. Nguyen; Michael C. Daugherty; Kevin D. Moeller

Angew. Chem. Int. Ed., 2019, 58, pp 3562-3565

Organic Electrochemistry and a Role Reversal: Using Synthesis To Optimize Electrochemical Methods

Nai-Hua Yeh, Matthew Medcalf, and Kevin D. Moeller*

J. Am. Chem. Soc., 2018, 140 (24), pp 7395–7398

Introduction: Electrochemistry: Technology, Synthesis, Energy, and Materials

R. Daniel Little, Kevin D. Moeller

Chem. Rev., 2018, 118 (9), pp 4483–4484

Using Physical Organic Chemistry To Shape the Course of Electrochemical Reactions

Kevin D. Moeller

Chem. Rev. 2018, 118, pp 94817-4833

Anodic Cyclization Reactions and the Mechanistic Strategies That Enable Optimization

Ruozhu Feng, Jake A. Smith, and Kevin D. Moeller

Acc. Chem. Res., 2017, 50 (9), pp 2346–2352

Insights into the Mechanism of Anodic N-N Bond Formation by Dehydrogenative Coupling

Gieshoff, Tile; Kehl, Anton; Schollmeyer, Dieter; Moeller, Kevin D.; Waldvogel, Siegfried R.

J. Am. Chem. Soc., 2017, 139(35), pp 12317–12324

Electrochemical synthesis of benzoxazoles from anilides – a new approach to employ amidyl radical intermediates

Tile Gieshoff, Anton Kehl, Dieter Schollmeyer, Kevin D. Moeller and Siegfried R. Waldvogel

Chem. Commun., 2017, 53, pp 2974-2977

Paired Electrolysis in the Simultaneous Production of Synthetic Intermediates and Substrates

Llorente, Mark J.; Nguyen, Bichlien H.; Kubiak, Clifford P.; Moeller, Kevin D.

J. Am. Chem. Soc., 2016, 138 (46), pp 15110–15113

New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of Concept

Graaf, M. D.; Marquez, B. V.; Yeh, N. – H.; Lapi, S. E.; Moeller, K. D. ACS Chem. Biol. 2016, 11, pp 2829– 2837

Considering organic mechanisms and the optimization of current flow in an electrochemical oxidative condensation reaction

D. T. Rensing, B. H. Nguyen and K. D. Moeller, Org. Chem. Front., 2016, 3, 1236–1240

Chemoselectivity and the Chan–Lam Coupling Reaction: Adding Amino Acids to Polymer-Coated Microelectrode Arrays

Matthew D. Graaf and Kevin D. Moeller, J. Org. Chem., 2016, 81, pp 1527–1534

Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog

Rensing, Derek T.; Uppal, Sakshi; Blumer, Kendall J. and Moeller, Kevin D. Org. Lett. 2015, 17, 2270-2273

Photoredox Catalysts: Synthesis of the Bipyrazine Ligand

Graaf, Matthew D. and Moeller, Kevin D. Journal of Organic Chemistry, 2015, 80, pp 2032-2035

Competition studies and the relative reactivity of enol ether and allylsilane coupling partners toward ketene dithioacetal derived radical cations

Campbell, John M.; Smith, Jake A.; Gonzalez, Luisalberto and Moeller, Kevin D. Tetrahedron Lett. 2015, 56, 3595−3599

Photovoltaic-driven organic electrosynthesis and efforts toward more sustainable oxidation reactions

Nguyen, Bichlien H.; Perkins, Robert J.; Smith, Jake A. and Moeller, Kevin D. Beilstein J. Org. Chem. 2015, 11, pp 280–287

Introduction to Microelectrode Arrays, the Site-Selective Functionalization of Electrode Surfaces, and the Real-Time Detection of Binding Events

Graaf, Matthew D. and Moeller, Kevin D. Langmuir 2015, 31, 28, 7697-7706

Intramolecular Anodic Olefin Coupling Reactions: Using Competition Studies to Probe the Mechanism of Oxidative Cyclization Reactions

Hai-Chao Xu and Kevin D. Moeller

Org. Lett., 2010, 12 (8), 1720–1723

Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites

Microelectrode Arrays, Electrocatalysis, and the Need for Proper Characterization

Anodic Cyclizations, Densely Functionalized Synthetic Building Blocks, and the Importance of Recent Mechanistic Observations

Anodic Cyclizations and Umpolung Reactions Involving Imines

A Building Block Approach for the Total Synthesis of YM-385781

Microelectrode arrays, electrosynthesis, and the optimization of signaling on an inert, stable surface

Building Chemical Probes Based on the Natural Products YM-254890 and FR900359: Advances toward Scalability

15 Paired Electrolysis

Lessons from an Array: Using an Electrode Surface to Control the Selectivity of a Solution-Phase Chemical Reaction

Electrochemistry in Synthetic Organic Chemistry

Capitalizing on Mediated Electrolyses for the Construction of Complex, Addressable Molecular Surfaces

Anodic Olefin Coupling Reactions: Elucidating Radical Cation Mechanisms and the Interplay between Cyclization and Second Oxidation Steps

Organic Electrochemistry: Expanding the Scope of Paired Reactions

Using a Combination of Electrochemical and Photoelectron Transfer Reactions to Gain New Insights into Oxidative Cyclization Reactions

Electrons, Electrodes, and the Transformation of Organic Molecules

From Molecules to Molecular Surfaces. Exploiting the Interplay Between Organic Synthesis and Electrochemistry

Electroorganic Synthesis and the Construction of Addressable Molecular Surfaces

Anodic Cyclizations, Seven-Membered Rings, and the Choice of Radical Cation vs. Radical Pathways

Paired Electrochemical Reactions and the On‐Site Generation of a Chemical Reagent

Organic Electrochemistry and a Role Reversal: Using Synthesis To Optimize Electrochemical Methods

Introduction: Electrochemistry: Technology, Synthesis, Energy, and Materials

Using Physical Organic Chemistry To Shape the Course of Electrochemical Reactions

Anodic Cyclization Reactions and the Mechanistic Strategies That Enable Optimization

Insights into the Mechanism of Anodic N-N Bond Formation by Dehydrogenative Coupling

Electrochemical synthesis of benzoxazoles from anilides – a new approach to employ amidyl radical intermediates

Paired Electrolysis in the Simultaneous Production of Synthetic Intermediates and Substrates

New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of Concept

Considering organic mechanisms and the optimization of current flow in an electrochemical oxidative condensation reaction

Chemoselectivity and the Chan–Lam Coupling Reaction: Adding Amino Acids to Polymer-Coated Microelectrode Arrays

Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-​254890 Analog

Photoredox Catalysts: Synthesis of the Bipyrazine Ligand

Competition studies and the relative reactivity of enol ether and allylsilane coupling partners toward ketene dithioacetal derived radical cations

Photovoltaic-​driven organic electrosynthesis and efforts toward more sustainable oxidation reactions

Introduction to Microelectrode Arrays, the Site-Selective Functionalization of Electrode Surfaces, and the Real-Time Detection of Binding Events

Microelectrode Arrays and the Use of PEG-Functionalized Diblock Copolymer Coatings

Electrochemically Generated Organometallic Reagents and Site-​Selective Synthesis on a Microelectrode Array

Microelectrode Arrays: A General Strategy for Using Oxidation Reactions to Site-selectively Modify Electrode Surfaces

Cyclization Reactions of Anode-Generated Amidyl Radicals

Silyl-Substituted Amino Acids: New Routes to the Construction of Selectively Functionalized Peptidomimetics

Building Addressable Libraries: Amino Acid Derived Fluorescent Linkers

Connecting the Dots: Using Sunlight to Drive Electrochemical Oxidations

Anodic Coupling Reactions: Exploring the Generality of Curtin−Hammett Controlled Reactions

Site-Selective, Cleavable Linkers: Quality Control and the Characterization of Small Molecules on Microelectrode Arrays

Site-Selectively Functionalizing Microelectrode Arrays: The Use of Cu(I)-Catalysts

Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays

Building Addressable Libraries: Site-Selective Use of Pd(0) Catalysts on Microelectrode Arrays

Intramolecular Hydroamination of Dithioketene Acetals: An Easy Route To Cyclic Amino Acid Derivatives

Intramolecular Anodic Olefin Coupling Reactions: Use of the Reaction Rate to Control Substrate/Product Selectivity

Anodic Coupling Reactions and the Synthesis of C-Glycosides

Intramolecular Anodic Olefin Coupling Reactions: Using Competition Studies to Probe the Mechanism of Oxidative Cyclization Reactions

Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog

Photovoltaic-driven organic electrosynthesis and efforts toward more sustainable oxidation reactions

Electrochemically Generated Organometallic Reagents and Site-Selective Synthesis on a Microelectrode Array