Building Addressable Libraries: The Use of “Safety-Catch” Linkers on Microelectrode Arrays

A “safety-catch” linker strategy has been used to site-selectively cleave and characterize molecules from a microelectrode array. The linkers are attached to the array by means of an ester and contain either a protected amine or protected alcohol nucleophile that can be released using acid generated at the microelectrodes.

Bo Bi, Karl Maurer, and Kevin D. Moeller

J. Am. Chem. Soc., 2010, 132 (49), 17405-17407