Integrative Muscle Physiology
Exploring the underpinnings of muscle pathology from cells to people.
- Skeletal muscle is one of the most adaptable tissues in the body – capable of dramatic changes in size and strength in response to physical load. However, with age, injury and disease the capacity of muscle to efficiently adapt declines. In these situations, healthy contractile tissue may be supplanted by connective tissue and fat which in turn impede the signals that drive adaptation. Our research aims to define the mechanisms that regulate the development and progression of cellular pathology in muscle and to design cell-based regenerative therapies to improve muscle’s ability to adapt to loading in the context of pathology.
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Check us out on the cover of the Journal of Physiology! (Also, read what’s inside)