Publications

Sviben S, Polino AJ, Melena I, Hughes JW. (2024) Immuno-Scanning Electron Microscopy of Islet Primary Cilia. J Cell Sci. https://doi.org/10.1242/jcs.262038.

Adamson SE & Hughes JW. (2024) Paracrine Signaling by Pancreatic Islet Cilia. Curr Opin Endo Metab Res. https://www.sciencedirect.com/science/article/pii/S2451965024000036

Adamson SE, Li ZA, Hughes JW. (2023) Beta cell primary cilia mediate somatostatin responsiveness via SSTR3. Islets. https://pubmed.ncbi.nlm.nih.gov/37660302/

Polino AJ, Sviben S, Melena I, Piston DW, Hughes JW. (2023) Scanning electron microscopy of human islet cilia. PNAS. https://www.pnas.org/doi/10.1073/pnas.2302624120 (cover)

Lee EY & Hughes JW. (2023) Rediscovering Primary Cilia in Pancreatic Islets. Diabetes & Metabolism Journal.  https://doi.org/10.4093/dmj.2022.0442

P. Chabosseau, F. Yong, L. F. Delgadillo-Silva, E. Y. Lee, R. Melhem, S. Li, N. Gandhi, J. Wastin, L. L. Noriega, I. Leclerc, Y. Ali, J. W. Hughes, R. Sladek, A. Martinez-Sanchez, G. A. Rutter. (2023) Molecular phenotyping of single pancreatic islet leader beta cells by “Flash-Seq.” Life Sciences, 121436.

Melena I, Hughes JW. (2022) Islet cilia and glucose homeostasis. Frontiers in Cell and Developmental Biology. DOI: https://doi.org/10.3389/fcell.2022.1082193

Cho JH, Li ZA, Zhu L, Muegge BM, Roseman HF, Utterback T, Woodhams L, Bayly PV, Hughes JW. (2022) Islet primary cilia controls insulin secretion. Science Advances. DOI: 10.1126/sciadv.abq8486 (selected for editorial comment)

Li Z, Cho JH, Woodhams L, Hughes JW. (2022) Fluorescent imaging of beta cell primary cilia. Frontiers in Endocrinology. PMC9540379 DOI: 10.3389/fendo.2022.1004136

Cho JH, Hughes JW. (2022) Cilia action in islets: lessons from mouse models. Frontiers in Endocrinology. PMID: 35813631

Hughes JW, Cho JH, Conway HE, DiGruccio MR, Ng XW, Roseman HF, Abreu D, Urano F, Piston DW. (2020) Primary cilia control glucose homeostasis via paracrine interactions. PNAS. PMID: 32253320

Miranda M, Carson C, St. Pierre C, Macias-Velasco J, Hughes J, Kunzmann M, Schmidt H, Wayhart J, Lawson H. (2020) Spontaneous restoration of functional β-cell mass in obese SM/J mice. Physiological Reports. PMID: 33113267

Hughes JW, Ustione A, Lavagnino Z, Piston D. (2018) Regulation of islet glucagon secretion: Beyond calcium. Diabetes, Obesity and Metabolism. PMID: 30230183

Vomund A, Zinselmyer B, Hughes J, Calderon B, Valderrama C, Ferris S, Wan X, Kanekura K, Carrero J, Urano F, Unanue E. (2015) Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. PNAS. PMID: 26324934.

Hughes JW, Vudattu N, Sznol M, Gettinger S, Kluger H, Lupsa B, & Herold KC. (2015) Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy. Diabetes Care. PMID: 25805871.