Hughes Lab

The Hughes lab at Washington University studies primary cilia, whose function as a cellular sensor and signaling hub underlies islet hormone secretion and cell-cell interactions. Metabolic diseases such as diabetes and obesity are influenced by primary cilia in many ways, which we are studying using imaging and cell biology approaches: 

• multi-modal microscopy
• live-cell sensors
• animal models of ciliopathy
• metabolic phenotyping
• proteomics
• transcriptomics