Our Focus

The Hughes lab at Washington University studies primary cilia, whose function as a cellular sensor and signaling hub underlies islet hormone secretion and cell-cell interactions. Metabolic diseases such as diabetes and obesity are influenced by primary cilia in many ways, which we are studying using imaging and cell biology approaches: 

  • multi-modal microscopy
  • live-cell sensors
  • animal models of ciliopathy
  • metabolic phenotyping
  • proteomics
  • transcriptomics

Contact Us

Hughes Lab

815 Southwest Tower, Barnes-Jewish Hospital

Washington University School of Medicine

(314) 362-7878



Division of Endocrinology, Metabolism & Lipid Research

Department of Cell Biology & Physiology

DBBS Graduate Program 

Washington University Diabetes Research Center