Our research focuses on the regulation of pancreatic islet function by primary cilia. We use:

  • Light and electron microscopy 
  • Live-cell imaging
  • Molecular biology
  • Genetic models
  • In vivo metabolic studies
Undergraduate researcher Henry Roseman examining islet ultrastructure on a JEOL electron microscope.

Primary cilia are specialized antennae that control cell-cell communication. In the pancreatic islets and ducts, cilia disruption leads to diabetes and cancer. We have generated novel mouse models to test how cilia control islet response to nutrients, calcium and cAMP activation, and whole-body metabolism. These studies will advance our understanding of islet physiology and diabetes. 

Our work is generously supported by:

  • The Integrated Islet Distribution Program (IIDP)
  • The Human Islet Research Network (HIRN)
  • Diabetes Research Connection (DRC)
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • Washington University Center for Cellular Imaging (WUCCI)
  • Washington University Diabetes Research Center (WU DRC)