Development
Yousef Abu-Amer, PhD
Investigating molecular mechanisms underlying inflammation-induced degenerative skeletal diseases including joint degeneration, inflammatory arthritis and osteolysis
Luis F. Z. Batista, PhD
Understanding the role of telomerase and other ribonucleoproteins during tissue homeostasis, regeneration, aging, and cancer
Douglas Chalker, PhD
Genetic and epigenetic regulation of developmentally programmed DNA rearrangements of Tetrahymena.
Grant Challen, PhD
Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells.
Shiming Chen, PhD
Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas.
Kyunghee Choi, PhD
We study molecular mechanisms that regulate hematopoietic and vascular development and regeneration.
Brian Clark, PhD
Analysis of the temporally regulated program of retinal cell type specification.
Joseph Corbo, MD, PhD
Our research has three major goals: (1) To elucidate the cis-regulatory architecture of the retina and to use this knowledge to treat blindness; (2) to understand the molecular and genetic basis of color vision, focusing on how animals both see and produce colors; and (3) to decipher the role of cis-regulatory variation in human cognition and neuropsychiatric disease.
Erika Crouch, MD, PhD
Our research focuses on the structure and function of collagenous carbohydrate binding proteins known as collectins.
Cristina de Guzman Strong, PhD
The long-term goal of the Strong laboratory is to understand the morphogenesis and homeostasis of functional tissue barriers.
Aaron DiAntonio, MD, PhD
Our laboratory investigates molecular mechanisms that control the structure and function of neural circuits in development and disease.
Ian Duncan, PhD
Temporal control of target gene specificity for developmental regulators in Drosophila.
Takeshi Egawa, MD, PhD
My laboratory’s main interest is understanding molecular mechanisms by which the development of lymphocytes, their clonal expansion and effector functions are regulated.
Guy Genin, PhD
My group studies how connections between dissimilar materials occur in nature, and applies this knowledge to propose and develop treatments and interventions.
Matthew Goldsmith, MD
My lab is interested in skeletal biology and growth control, including growth during normal ontogeny and during the regeneration of tissues/organs.
Farshid Guilak, PhD
We focus on the role of biomechanical factors in the onset, progression, and treatment of osteoarthritis and other joint diseases.
Erik Herzog, PhD
Our laboratory studies the cellular and molecular bases for circadian rhythms in mammals.
Jing Hughes, MD, PhD
We study how cilia control islet response to nutrients, calcium and cAMP activation, and whole-body metabolism.
Sanjay Jain, MD, PhD
The Jain lab studies interactions between the nervous and genitourinary systems during development, molecular basis for heterogeneity in progenitors and their lineage commitments in the GU tract, injury and regeneration using animal models, mechanisms of malformations using organoids from iPSCs.
Charles Kaufman, MD, PhD
Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease.
Daniel Kerschensteiner, MD
To goals of our research are (1) to understand how neural circuits process information, (2) to uncover the principles and mechanisms that guide their development, (3) to develop approaches to preserve and restore circuit function in neurodegenerative diseases.
S. Kerry Kornfeld, MD, PhD
DRSCB Program Co-Director
Our research addresses two areas—organismal aging and the biology of metals during growth and development.
Kristen Kroll, PhD
Transcriptional and epigenetic regulation of neural development and its dysregulation in neurodevelopmental disorders.
Kory Lavine, MD, PhD
Identify signaling pathways that mediate cardiac tissue repair/regeneration and heart failure pathogenesis.
Qingyun "Tristan" Li, PhD
Microglial biology and neuro-immune interactions in development, aging and disease.
Jeffrey Magee, MD, PhD
Developmental context and genetic variation as underlying mechanisms of childhood cancer.
Moe Mahjoub, PhD
The focus of research in my laboratory is to define the functions of the microtubule cytoskeleton, specifically the centrosome and cilium, during mammalian development.
Helen McNeill, PhD
DRSCB Program Co-Director
The overall goal of research in the McNeill lab is to understand at a cellular level how tissue growth and tissue organization are regulated during normal development, and how loss of this control leads to human disease.
Robert Mecham, PhD
A major goal of our research is to understand the complex process of extracellular matrix (ECM) secretion and assembly, with a particular focus on ECM proteins important to the cardiovascular and pulmonary systems.
Craig Micchelli, PhD
Our laboratory investigates the basis of stem cell behavior in their native tissue microenvironments.
Jeffrey Milbrandt, MD, PhD
Axonal degeneration, regulation of myelination, neuronal energetics and mitochondrial function in neuropathy and neurodegenerative disease.
Jeffrey Miner, PhD
The main interest of my laboratory is the role of the glomerular basement membrane (GBM) in kidney function and disease.
Josh Morgan, PhD
Use advanced cellular imaging techniques to investigate how neurons organize themselves into image processing circuits.
Samantha Morris, PhD
Developing new single-cell technologies to create high-resolution maps of lineage and identity; Manipulating gene regulatory networks, via direct lineage reprogramming, to generate clinically valuable cell types.
David Ornitz, MD, PhD
Regulation of lung, skeletal, and cardiovascular development, injury response, and regeneration by Fibroblast Growth Factors.
Philip Osdoby, PhD
Bone remodeling cell and molecular events of osteoclast activity and development.
Deborah Rubin, MD, PhD
Intestinal stem cells and the stem cell niche in intestinal injury/short bowel syndrome and colitis associated colon cancer.
