Our laboratory studies the genetic determinants and pathogenic mechanisms of kidney diseases and cancer with the goal of improving diagnostic and therapeutic strategies targeting these diseases. We are an interdisciplinary team combining experimental biology and computational analyses to advance precision medicine. We attack important and challenging problems by integrating data from human specimens, cell lines, organoids, patient-derived xenograft models, and murine genetic models into a comprehensive experimental & analytical framework. Our lab collaborates extensively with other Washington University basic/translational scientists, oncologists, and computational biologists. We are also heavily involved in multiple large-scale NIH consortia, including HTAN, PDXNet, CPTAC, SenNet, and GUDMAP, where we use multi-omics (including single cell and spatial omics) and advanced imaging technologies (including CODEX and 3D imaging) to study disease etiology and treatment, as well as building reference databases and atlases for the research community. The research environment is highly collaborative, intellectually stimulating, and enjoyable.