Welcome to the Wang lab!
How are the micron-scale functions of organelles determined by the assembly of nanometer-scale proteins? How do complex structures grow and duplicate? How are non-membrane-bound organelles differentiated from the cytoplasm?
The Wang lab (Dr. Jennifer Wang, PI) studies these questions in the context of the mammalian centrosome-cilium complex. This highly conserved structure is involved in cell division, signaling and motility. We use CRISPR/Cas9 gene editing, high resolution microscopy, and biochemical techniques to investigate how this complex forms and functions.