SELECTED PUBLICATIONS (Complete list on PubMed)
Kim DH, Wang Y, Jung H, Field RL, Zhang X, Liu T, Ma C, Fraser JS, Brestoff JR, Van Dyken SJ. (2023). A type 2 immune circuit in the stomach controls mammalian adaptation to dietary chitin. Science 381(6662):1092-1098.
Díaz RE, Ecker AK, Correy GJ, Asthana P, Young ID, Faust B, Thompson MC, Seiple IB, Van Dyken SJ, Locksley RM, Fraser JS. (2023). Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. bioRxiv Jun 28; doi: 10.1101/2023.06.03.542675.
Hou J, Zhou Y, Cai Z, Terekhova M, Swain A, Andhey PS, Guimaraes RM, Ulezko Antonova A, Qiu T, Sviben S, Strout G, Fitzpatrick JAJ, Chen Y, Gilfillan S, Kim DH, Van Dyken SJ, Artyomov MN, Colonna M. (2023). Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination. Cell Rep. 42(4):112293.
Liu TT, Kim S, Desai P, Kim DH, Huang X, Ferris ST, Wu R, Ou F, Egawa T, Van Dyken SJ, Diamond MS, Johnson PF, Kubo M, Murphy TL, Murphy KM. (2022). Ablation of cDC2 development by triple mutations within the Zeb2 enhancer. Nature 607(7917):142-148.
Panda SK, Kim DH, Desai P, Rodrigues PF, Sudan R, Gilfillan S, Cella M, Van Dyken SJ, Colonna M. (2022). SLC7A8 is a key amino acids supplier for the metabolic programs that sustain homeostasis and activation of type 2 innate lymphoid cells. Proc. Natl. Acad. Sci. U.S.A. 119(46):e2215528119.
Wang WL, Kasamatsu J, Joshita S, Gilfillan S, Di Luccia B, Panda SK, Kim DH, Desai P, Bando JK, Huang SC, Yomogida K, Hoshino H, Fukushima M, Jacobsen EA, Van Dyken SJ, Ruedl C, Cella M, Colonna M. (2022). The aryl hydrocarbon receptor instructs the immunomodulatory profile of a subset of Clec4a4(+) eosinophils unique to the small intestine. Proc. Natl. Acad. Sci. U.S.A. 119(23):e2204557119.
Jung H, Kim DH, Wang Y, Van Dyken SJ. (2022). Finding a Niche: Tissue Immunity and Innate Lymphoid Cells. Adv. Exp. Med. Biol. 1365:57-73.
Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A, McIntire KM, Singamaneni S, Sutterwala F, Morley SC. (2022). L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis. Cell Rep. 38(11):110507.
Kotas ME, Dion J, Van Dyken S, Ricardo-Gonzalez RR, Danel CJ, Taillé C, Mouthon L, Locksley RM, Terrier B. (2021). A role for IL-33-activated ILC2s in eosinophilic vasculitis. JCI Insight. 6(12).
Kim DH and Van Dyken SJ. (2020). ILC2s in High Definition: Decoding the Logic of Tissue-Based Immunity. Trends Immunol. Jan. 41(1):7-16.
Barad BA, Liu L, Diaz RE, Basilio R, Van Dyken SJ, Locksley RM, Fraser JS. (2020). Differences in the chitinolytic activity of mammalian chitinases on soluble and insoluble substrates. Protein Sci. 2020 29:966-977.
Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A. (2020). Ly6c(Lo) non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Sci. Rep. 28;10(1):7165.
Jarjour NN, Bradstreet TR, Schwarzkopf EA, Cook ME, Lai CW, Huang SC, Taneja R, Stappenbeck TS, Van Dyken SJ, Urban JF Jr, Edelson BT. (2020). BHLHE40 Promotes T(H)2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines. J Immunol. 204(4):923-932.
Ricardo-Gonzales RR,* Van Dyken SJ,* Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. (2018). Tissue signals imprint ILC2 identity with anticipatory function. Nat. Immunol. 19:1093-1099. *Equal contribution.
Van Dyken SJ and Locksley RM. (2018). Chitins and chitinase activity in airway diseases. J. Allergy Clin. Immunol. 142(2):364-369.
Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken SJ, Iashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. (2018). Pulmonary neuroendocrine cells amplify allergic asthma responses. Science 360:eaan8546.
Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. (2017). Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell 169(3):497-503.e13.
Van Dyken SJ,* Nussbaum JC,* Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. (2016). A tissue checkpoint regulates type 2 immunity. Nat. Immunol. 17:1381-87. *Equal contribution.
Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. (2015). Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity 43(1):161-74.
Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie ANJ, Krummel MF, Liang HE, Locksley RM. (2014). Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity 40(3):414-24.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. (2013). Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 502:245-48.
Van Dyken SJ and Locksley RM. (2013). Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Ann. Rev. Immunol. 31:317-43.
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