SELECTED PUBLICATIONS (Complete list on PubMed)

Kim DH, Van Dyken SJ. (2020). ILC2s in High Definition: Decoding the Logic of Tissue-Based Immunity. Trends Immunol. Jan. 41(1):7-16 https://doi.org/10.1016/j.it.2019.11.003

Ricardo-Gonzales RR,*  Van Dyken SJ,*  Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM.  Tissue signals imprint ILC2 identity with anticipatory function.  Nat. Immunol., in press.   *Equal contribution.


Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken SJ, Iashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. (2018). Pulmonary neuroendocrine cells amplify allergic asthma responses.  Science Jun 8;360(6393). pii:eaan8546. 


Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. (2017).  Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.  Cell 169(3):497-503.e13. 


Van Dyken SJ,* Nussbaum JC,* Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. (2016).  A tissue checkpoint regulates type 2 immunity.  Nat. Immunol. 17:1381-87. *Equal contribution.


Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. (2016).  Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.  Mucosal Immunol. 9(1):275-86.


Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, Van Dyken SJ, Wagner JG, Harkema JR. (2016).  Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells.   Am. J. Respir. Cell. Mol. Biol. 54(6):782-91.


Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. (2015).  Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.  Immunity 43(1):161-74.


Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie ANJ, Krummel MF, Liang HE, Locksley RM. (2014).  Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.  Immunity 40(3):414-24.


O’Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton (2014).  Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.  Infect. Immun. 82(8):3199-205.


Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. (2013).  Type 2 innate lymphoid cells control eosinophil homeostasis.  Nature 502:245-48.  


Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. (2013).  Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.   J. Exp. Med. 210(3):535-49.


Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM. (2011).  Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.  J. Immunol.187(5):2261-7.  


Hernandez JD, Klein J, Van Dyken SJ, Marth JD, Baum LG. (2007).  T-cell activation results in microheterogeneous changes in glycosylation of CD45.  Int. Immunol. 19(7):847-56.


Van Dyken SJ, Green RS, Marth JD. (2007).  Structural and mechanistic features of protein O-glycosylation linked to CD8+ T-cell apoptosis.  Mol. Cell. Biol. 27(3):1096-111.


Brennan PJ, Saouaf SJ, Van Dyken S, Marth JD, Li B, Bhandoola A, Greene MI. (2005).  Sialylation regulates peripheral tolerance in CD4+ T cells.  Int. Immunol. 18(5):627-35.


Moody AM, North SJ, Reinhold B, Van Dyken SJ, Rogers ME, Panico M, Dell A, Morris HR, Marth JD, Reinherz EL. (2003).  Sialic acid capping of CD8β core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.  J. Biol. Chem. 278(9):7240-6.


REVIEWS & COMMENTARIES

Van Dyken SJ and Locksley RM. (2018).  Chitins and chitinase activity in airway diseases.  J. Allergy Clin. Immunol. 142(2):364-369.


Van Dyken SJ and Locksley RM. (2013).  Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.  Ann. Rev. Immunol. 31:317-43.


Van Dyken SJ and Locksley RM. (2007).  Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity.   Immunol. Cell. Biol. 85(8):572-4.


ORCID iD iconorcid.org/0000-0002-9787-0883