Circadian pacemaker neurons display co-phasic rhythms in basal calcium level and in fast calcium fluctuations. Liang X, Holy TE, Taghert PH. BioRXiv 2021 Preprint

Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay. Liang X, Ho MCW, Zhang Y, Li Y, Wu MN, Holy TE, Taghert PH. Neuron. 2019 May 22;102(4):843-857.e4. doi: 10.1016/j.neuron.2019.03.028. Epub 2019 Apr 10.PMID: 30981533 

EJCB – Molecular basis of protein fates in the secretory and endocytic pathways, and beyond. Couture F, Jansen AM, Taghert P, Brix K. Eur J Cell Biol. 2017 Aug;96(5):369-371. doi: 10.1016/j.ejcb.2017.06.006. Epub 2017 Jun 15.PMID: 28754257 

A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs. Liang X, Holy TE, Taghert PH. Neuron. 2017 Jun 21;94(6):1173-1189.e4. doi: 10.1016/j.neuron.2017.05.007. Epub 2017 May 25.PMID: 28552314 

Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation. Klose M, Duvall L, Li W, Liang X, Ren C, Steinbach JH, Taghert PH. Neuron. 2016 May 18;90(4):781-794. doi: 10.1016/j.neuron.2016.04.002. Epub 2016 May 5.PMID: 27161526 

Synchronous Drosophila circadian pacemakers display nonsynchronous Ca²⁺ rhythms in vivo. Liang X, Holy TE, Taghert PH. Science. 2016 Feb 26;351(6276):976-81. doi: 10.1126/science.aad3997.PMID: 26917772 

The Splice Isoforms of the Drosophila Ecdysis Triggering Hormone Receptor Have Developmentally Distinct Roles. Diao F, Mena W, Shi J, Park D, Diao F, Taghert P, Ewer J, White BH. Genetics. 2016 Jan;202(1):175-89. doi: 10.1534/genetics.115.182121. Epub 2015 Nov 3.PMID: 26534952 

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo. Bohn LM, Lohse MJ, Nitabach MN, Taghert PH, Smit MJ. Mol Pharmacol. 2015 Sep;88(3):534-5. doi: 10.1124/mol.115.100750. Epub 2015 Jul 10.PMID: 26162863 

The Drosophila Prosecretory Transcription Factor dimmed Is Dynamically Regulated in Adult Enteroendocrine Cells and Protects Against Gram-Negative Infection. Beebe K, Park D, Taghert PH, Micchelli CA. G3 (Bethesda). 2015 May 20;5(7):1517-24. doi: 10.1534/g3.115.019117.PMID: 25999585 

Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED. Hadžić T, Park D, Abruzzi KC, Yang L, Trigg JS, Rohs R, Rosbash M, Taghert PH. Nucleic Acids Res. 2015 Feb 27;43(4):2199-215. doi: 10.1093/nar/gku1377. Epub 2015 Jan 29.PMID: 25634895 

Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED. Park D, Li P, Dani A, Taghert PH. J Neurosci. 2014 Sep 24;34(39):13195-207. doi: 10.1523/JNEUROSCI.2075-14.2014.PMID: 25253864 

E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila.
Duvall LB, Taghert PH. J Biol Rhythms. 2013 Aug;28(4):239-48. doi: 10.1177/0748730413497179.PMID: 23929551 

Peptide neuromodulation in invertebrate model systems. Taghert PH, Nitabach MN. Neuron. 2012 Oct 4;76(1):82-97. doi: 10.1016/j.neuron.2012.08.035.PMID: 23040808 

The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila. Duvall LB, Taghert PH. PLoS Biol. 2012;10(6):e1001337. doi: 10.1371/journal.pbio.1001337. Epub 2012 Jun 5.PMID: 22679392 

Therapeutic peptide production in Drosophila. Park D, Hou X, Sweedler JV, Taghert PH. Peptides. 2012 Aug;36(2):251-6. doi: 10.1016/j.peptides. 2012.05.003. Epub 2012 May 15.PMID: 22595312 

Circadian pacemakers: how clock properties relate to their cellular properties. Taghert PH. Curr Biol. 2011 Nov 8;21(21):R894-6. doi: 10.1016/j.cub.2011.09.041.PMID: 22075431 

Scaling factors: transcription factors regulating subcellular domains. Mills JC, Taghert PH. Bioessays. 2012 Jan;34(1):10-6. doi: 10.1002/bies.201100089. Epub 2011 Oct 26.PMID: 22028036 

Molecular organization of Drosophila neuroendocrine cells by Dimmed. Park D, Hadžić T, Yin P, Rusch J, Abruzzi K, Rosbash M, Skeath JB, Panda S, Sweedler JV, Taghert PH. Curr Biol. 2011 Sep 27;21(18):1515-24. doi: 10.1016/j.cub.2011.08.015. Epub 2011 Sep 1.PMID: 21885285 

PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila. Im SH, Li W, Taghert PH.PLoS One. 2011 Apr 29;6(4):e18974. doi: 10.1371/journal.pone.0018974.PMID: 21559487 

Circadian rhythms: biological clocks work in phospho-time. Duvall LB, Taghert PH.Curr Biol. 2011 May 10;21(9):R305-7. doi: 10.1016/j.cub.2011.04.005.PMID: 21549947

Neuroscience. A CRY to rise. Im SH, Taghert PH. Science. 2011 Mar 18;331(6023):1394-5. doi: 10.1126/science.1204293.PMID: 21415342 

PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila. Im SH, Taghert PH. J Comp Neurol. 2010 Jun 1;518(11):1925-45. doi: 10.1002/cne.22311.PMID: 20394051 

Transcriptional orchestration of the regulated secretory pathway in neurons by the bHLH protein DIMM. Hamanaka Y, Park D, Yin P, Annangudi SP, Edwards TN, Sweedler J, Meinertzhagen IA, Taghert PH. Curr Biol. 2010 Jan 12;20(1):9-18. doi: 10.1016/j.cub.2009.11.065. Epub 2009 Dec 31.PMID: 20045330 

RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide’s circadian functions. Shafer OT, Taghert PH. PLoS One. 2009 Dec 14;4(12):e8298. doi: 10.1371/journal.pone.0008298.PMID: 20011537 

Circadian biology: a neuropeptide is bound to activate its receptor.
Taghert PH. Curr Biol. 2009 Aug 25;19(16):R696-7. doi: 10.1016/j.cub.2009.07.009.PMID: 19706280
Peptidergic neurosecretory cells in insects: organization and control by the bHLH protein DIMMED.Park D, Taghert PH. Gen Comp Endocrinol. 2009 May 15;162(1):2-7. doi: 10.1016/j.ygcen.2008.12.012. Epub 2008 Dec 24.PMID: 19135054 

Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Shafer OT, Kim DJ, Dunbar-Yaffe R, Nikolaev VO, Lohse MJ, Taghert PH. Neuron. 2008 Apr 24;58(2):223-37. doi: 10.1016/j.neuron.2008.02.018.PMID: 18439407 

Mapping peptidergic cells in Drosophila: where DIMM fits in. Park D, Veenstra JA, Park JH, Taghert PH. PLoS One. 2008 Mar 26;3(3):e1896. doi: 10.1371/journal.pone.0001896.PMID: 18365028 

Organization of the Drosophila circadian control circuit. Nitabach MN, Taghert PH. Curr Biol. 2008 Jan 22;18(2):R84-93. doi: 10.1016/j.cub.2007.11.061.PMID: 18211849 Review.

The Drosophila basic helix-loop-helix protein DIMMED directly activates PHM, a gene encoding a neuropeptide-amidating enzyme. Park D, Shafer OT, Shepherd SP, Suh H, Trigg JS, Taghert PH. Mol Cell Biol. 2008 Jan;28(1):410-21. doi: 10.1128/MCB.01104-07. Epub 2007 Oct 29.PMID: 17967878 

Mechanisms of clock output in the Drosophila circadian pacemaker system. Taghert PH, Shafer OT. J Biol Rhythms. 2006 Dec;21(6):445-57. doi: 10.1177/0748730406293910.PMID: 17107935 

Development and morphology of the clock-gene-expressing lateral neurons of Drosophila melanogaster. Helfrich-Förster C, Shafer OT, Wülbeck C, Grieshaber E, Rieger D, Taghert P. J Comp Neurol. 2007 Jan 1;500(1):47-70. doi: 10.1002/cne.21146.PMID: 17099895

Reevaluation of Drosophila melanogaster’s neuronal circadian pacemakers reveals new neuronal classes.
Shafer OT, Helfrich-Förster C, Renn SC, Taghert PH. J Comp Neurol. 2006 Sep 10;498(2):180-93. doi: 10.1002/cne.21021.PMID: 16856134 

PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors.
Mertens I, Vandingenen A, Johnson EC, Shafer OT, Li W, Trigg JS, De Loof A, Schoofs L, Taghert PH. Neuron. 2005 Oct 20;48(2):213-9. doi: 10.1016/j.neuron.2005.09.009.PMID: 16242402 

Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides.Birse RT, Johnson EC, Taghert PH, Nässel DR. J Neurobiol. 2006 Jan;66(1):33-46. doi: 10.1002/neu.20189.PMID: 16193493

Lithium- and valproate-induced alterations in circadian locomotor behavior in Drosophila.Dokucu ME, Yu L, Taghert PH. Neuropsychopharmacology. 2005 Dec;30(12):2216-24. doi: 10.1038/sj.npp.1300764.PMID: 15956996

A novel diuretic hormone receptor in Drosophila: evidence for conservation of CGRP signaling.Johnson EC, Shafer OT, Trigg JS, Park J, Schooley DA, Dow JA, Taghert PH. J Exp Biol. 2005 Apr;208(Pt 7):1239-46. doi: 10.1242/jeb.01529.PMID: 15781884

Regulators acting in combinatorial codes also act independently in single differentiating neurons.Allan DW, Park D, St Pierre SE, Taghert PH, Thor S. Neuron. 2005 Mar 3;45(5):689-700. doi: 10.1016/j.neuron.2005.01.026.PMID: 15748845 

The neuropeptide pigment-dispersing factor coordinates pacemaker interactions in the Drosophila circadian system.Lin Y, Stormo GD, Taghert PH. J Neurosci. 2004 Sep 8;24(36):7951-7. doi: 10.1523/JNEUROSCI.2370-04.2004.PMID: 15356209 

Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2.Han M, Park D, Vanderzalm PJ, Mains RE, Eipper BA, Taghert PH. J Neurochem. 2004 Jul;90(1):129-41. doi: 10.1111/j.1471-4159.2004.02464.x.PMID: 15198673

Ap-let neurons–a peptidergic circuit potentially controlling ecdysial behavior in Drosophila.Park D, Han M, Kim YC, Han KA, Taghert PH. Dev Biol. 2004 May 1;269(1):95-108. doi: 10.1016/j.ydbio.2004.01.015.PMID: 15081360

Drosophila CG8422 encodes a functional diuretic hormone receptor.Johnson EC, Bohn LM, Taghert PH. J Exp Biol. 2004 Feb;207(Pt 5):743-8. doi: 10.1242/jeb.00818.PMID: 14747406

Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.Johnson EC, Bohn LM, Barak LS, Birse RT, Nässel DR, Caron MG, Taghert PH. J Biol Chem. 2003 Dec 26;278(52):52172-8. doi: 10.1074/jbc.M306756200. Epub 2003 Oct 10.PMID: 14555656

Circadian rhythms: in the loop at last.Van Gelder RN, Herzog ED, Schwartz WJ, Taghert PH. Science. 2003 Jun 6;300(5625):1534-5. doi: 10.1126/science.1085446.PMID: 12791982

Drosophila neuropeptide signaling.Taghert PH, Veenstra JA. Adv Genet. 2003;49:1-65. doi: 10.1016/s0065-2660(03)01001-0.PMID: 12779250 Review.

Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophilamelanogaster.
Johnson EC, Garczynski SF, Park D, Crim JW, Nassel DR, Taghert PH. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6198-203. doi: 10.1073/pnas.1030108100. Epub 2003 May 2.PMID: 12730362 

The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila.
Hewes RS, Park D, Gauthier SA, Schaefer AM, Taghert PH. Development. 2003 May;130(9):1771-81. doi: 10.1242/dev.00404.PMID: 12642483

Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.
Lin Y, Han M, Shimada B, Wang L, Gibler TM, Amarakone A, Awad TA, Stormo GD, Van Gelder RN, Taghert PH. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9562-7. doi: 10.1073/pnas.132269699. Epub 2002 Jun 27.PMID: 12089325 

Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila.Taghert PH, Hewes RS, Park JH, O’Brien MA, Han M, Peck ME. J Neurosci. 2001 Sep 1;21(17):6673-86. doi: 10.1523/JNEUROSCI.21-17-06673.2001.PMID: 11517257 

How does the circadian clock send timing information to the brain?Taghert PH. Semin Cell Dev Biol. 2001 Aug;12(4):329-41. doi: 10.1006/scdb.2001.0260.PMID: 11463217 

Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome.
Hewes RS, Taghert PH. Genome Res. 2001 Jun;11(6):1126-42. doi: 10.1101/gr.169901.PMID: 11381038 

PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila.Jiang N, Kolhekar AS, Jacobs PS, Mains RE, Eipper BA, Taghert PH. Dev Biol. 2000 Oct 1;226(1):118-36. doi: 10.1006/dbio.2000.9832.PMID: 10993678

The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila.
Hewes RS, Schaefer AM, Taghert PH. Genetics. 2000 Aug;155(4):1711-23.PMID: 10924469 

Metamorphosis of tangential visual system neurons in Drosophila.Taghert PH, Roberts ME, Renn SC, Jacobs PS. Dev Biol. 2000 Jun 15;222(2):471-85. doi: 10.1006/dbio.2000.9724.PMID: 10837134

Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion.Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I. J Biol Chem. 2000 Jun 9;275(23):17886-93. doi: 10.1074/jbc.M000032200.PMID: 10749852

A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila.Renn SC, Park JH, Rosbash M, Hall JC, Taghert PH. Cell. 1999 Dec 23;99(7):791-802. doi: 10.1016/s0092-8674(00)81676-1.PMID: 10619432

Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex.Renn SC, Armstrong JD, Yang M, Wang Z, An X, Kaiser K, Taghert PH. J Neurobiol. 1999 Nov 5;41(2):189-207.PMID: 10512977

FMRFamide neuropeptides and neuropeptide-associated enzymes in Drosophila.
Taghert PH. Res Tech. 1999 Apr 15;45(2):80-95. doi: 10.1002/(SICI)1097-0029(19990415)45:2<80::AID-JEMT3>3.0.CO;2-X.PMID: 10332726 Review.

Cell type-specific regulatory sequences control expression of the Drosophila FMRF-NH2 neuropeptide gene.Benveniste RJ, Taghert PH. J Neurobiol. 1999 Mar;38(4):507-20. doi: 10.1002/(sici)1097-4695(199903)38:4<507::aid-neu7>;2-x.PMID: 10084686

Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor.Benveniste RJ, Thor S, Thomas JB, Taghert PH. Development. 1998 Dec;125(23):4757-65.PMID: 9806924

Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction.
Hewes RS, Snowdeal EC 3rd, Saitoe M, Taghert PH. J Neurosci. 1998 Sep 15;18(18):7138-51. doi: 10.1523/JNEUROSCI.18-18-07138.1998.PMID: 9736637 

Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster.
Renn SC, Tomkinson B, Taghert PH. J Biol Chem. 1998 Jul 24;273(30):19173-82. doi: 10.1074/jbc.273.30.19173.PMID: 9668104 

A peritracheal neuropeptide system in insects: release of myomodulin-like peptides at ecdysis.
O’Brien MA, Taghert PH. J Exp Biol. 1998 Jan;201(Pt 2):193-209.PMID: 9405303

Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation.Kolhekar AS, Roberts MS, Jiang N, Johnson RC, Mains RE, Eipper BA, Taghert PH. J Neurosci. 1997 Feb 15;17(4):1363-76. doi: 10.1523/JNEUROSCI.17-04-01363.1997.PMID: 9006979 

Drosophila MEF2, a transcription factor that is essential for myogenesis.Bour BA, O’Brien MA, Lockwood WL, Goldstein ES, Bodmer R, Taghert PH, Abmayr SM, Nguyen HT. Genes Dev. 1995 Mar 15;9(6):730-41. doi: 10.1101/gad.9.6.730.PMID: 7729689 

The genetic analysis of neuropeptide signaling systems.O’Brien MA, Taghert PH. Zoolog Sci. 1994 Oct;11(5):633-45.PMID: 7765852 Review. 

A genetic and molecular analysis of the 46C chromosomal region surrounding the FMRFamide neuropeptide gene in Drosophila melanogaster.O’Brien MA, Roberts MS, Taghert PH. Genetics. 1994 May;137(1):121-37.PMID: 8056304 

An immunocytochemical study of the FMRFamide neuropeptide gene products in Drosophila.Schneider LE, Sun ET, Garland DJ, Taghert PH. J Comp Neurol. 1993 Nov 15;337(3):446-60. doi: 10.1002/cne.903370308.PMID: 8282851

Cell type-specific transcriptional regulation of the Drosophila FMRFamide neuropeptide gene.Schneider LE, Roberts MS, Taghert PH. Neuron. 1993 Feb;10(2):279-91. doi: 10.1016/0896-6273(93)90318-l.PMID: 8439413

Molecular genetic analysis of the FMRFamide-related neuropeptides in Drosophila.Taghert PH, O’Brien MA, Schneider LE, Roberts MS. Prog Brain Res. 1992;92:163-74. doi: 10.1016/s0079-6123(08)61173-5.PMID: 1302876 Review. 

Origins of the insect enteric nervous system: differentiation of the enteric ganglia from a neurogenic epithelium.Copenhaver PF, Taghert PH. Development. 1991 Dec;113(4):1115-32.PMID: 1811931

The timing of initial neuropeptide expression by an identified insect neuron does not depend on interactions with its normal peripheral target.Wall JB, Taghert PH. J Neurobiol. 1991 Dec;22(9):935-56. doi: 10.1002/neu.480220906.PMID: 1795159

Segment-specific modifications of a neuropeptide phenotype in embryonic neurons of the moth, Manduca sexta.Wall JB, Taghert PH. J Comp Neurol. 1991 Jul 15;309(3):375-90. doi: 10.1002/cne.903090307.PMID: 1918442

In situ hybridization analysis of the FMRFamide neuropeptide gene in Drosophila. II. Constancy in the cellular pattern of expression during metamorphosis.O’Brien MA, Schneider LE, Taghert PH. J Comp Neurol. 1991 Feb 22;304(4):623-38. doi: 10.1002/cne.903040409.PMID: 1672877

In situ hybridization analysis of the FMRFamide neuropeptide gene in Drosophila. I. Restricted expression in embryonic and larval stages.Schneider LE, O’Brien MA, Taghert PH. J Comp Neurol. 1991 Feb 22;304(4):608-22. doi: 10.1002/cne.903040408.PMID: 1672876

Interspecific comparison of a Drosophila gene encoding FMRFamide-related neuropeptides.Taghert PH, Schneider LE. J Neurosci. 1990 Jun;10(6):1929-42. doi: 10.1523/JNEUROSCI.10-06-01929.1990.PMID: 2113087 

Neurogenesis in the insect enteric nervous system: generation of premigratory neurons from an epithelial placode.Copenhaver PF, Taghert PH.Development. 1990 May;109(1):17-28.PMID: 2209463

Organization and expression of the Drosophila Phe-Met-Arg-Phe-NH2 neuropeptide gene.Schneider LE, Taghert PH. J Biol Chem. 1990 Apr 25;265(12):6890-5.PMID: 2324103

Pair-rule expression of a cell surface molecule during gastrulation of the moth embryo.Carr JN, Taghert PH. Development. 1989 Sep;107(1):143-51.PMID: 2627891

Development of the enteric nervous system in the moth. II. Stereotyped cell migration precedes the differentiation of embryonic neurons.Copenhaver PF, Taghert PH. Dev Biol. 1989 Jan;131(1):85-101. doi: 10.1016/s0012-1606(89)80040-5.PMID: 2909411

Development of the enteric nervous system in the moth. I. Diversity of cell types and the embryonic expression of FMRFamide-related neuropeptides.Copenhaver PF, Taghert PH. Dev Biol. 1989 Jan;131(1):70-84. doi: 10.1016/s0012-1606(89)80039-9.PMID: 2909410

Formation of the transverse nerve in moth embryos. II. Stereotyped growth by the axons of identified neuroendocrine neurons.
Carr JN, Taghert PH. Dev Biol. 1988 Dec;130(2):500-12. doi: 10.1016/0012-1606(88)90345-4.PMID: 3197922

Formation of the transverse nerve in moth embryos. I. A scaffold of nonneuronal cells prefigures the nerve.Carr JN, Taghert PH. Dev Biol. 1988 Dec;130(2):487-99. doi: 10.1016/0012-1606(88)90344-2.PMID: 3058542

Isolation and characterization of a Drosophila gene that encodes multiple neuropeptides related to Phe-Met-Arg-Phe-NH2 (FMRFamide).Schneider LE, Taghert PH. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1993-7. doi: 10.1073/pnas.85.6.1993.PMID: 3162321 

Developmental neurobiology. Trophic factor theory matures.Lichtman JW, Taghert PH. Nature. 1987 Mar 26-Apr 1;326(6111):336. doi: 10.1038/326336a0.PMID: 3031503 

Developmental neurobiology. Axon outgrowth in vertebrates.Taghert PH, Lichtman JW. Nature. 1986 Mar 20-26;320(6059):210-11. doi: 10.1038/320210a0.PMID: 3960104