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2023
Okuno, Y. and Clore, G.M., Extending the Experimentally Accessible Range of Spin Dipole-Dipole Spectral Densities for Protein-Cosolute Interactions by Temperature-Dependent Solvent Paramagnetic Relaxation Enhancement Measurements. The Journal of Physical Chemistry B
2022
Tugarinov, V., Okuno, Y., Torricella, F., Karamanos, K. T., Clore, G. M., A “Steady-State” Relaxation Dispersion Nuclear Magnetic Resonance Experiment for Studies of Chemical Exchange in Degenerate 1H Transitions of Methyl Groups. The Journal of Physical Chemistry Letters 13 (48), 11271-11279.
Okuno, Y., Schwieters, C.D., Yang, Z., Clore, G.M. Theory and Applications of Nitroxide-based Paramagnetic Cosolutes for Probing Intermolecular and Electrostatic Interactions on Protein Surfaces. J. Am. Chem. Soc, 144 (46), 21371-21388
2021
Okuno, Y., Yoo, J., Schwieters, C.D., Best, R.B., Chung, H.S. & Clore, G.M. Atomic view of cosolute-induced protein denaturation probed by NMR solvent paramagnetic relaxation enhancement. Proc. Natl. Acad. Sci. 118, e211202118
2020
Schmidts, T., Jeon, J., Okuno, Y., Chilveri, S.C., Clore, G. M. Submillisecond Freezing Permits Cryoprotectant‐Free EPR Double Electron− Electron Resonance Spectroscopy. Chem. Phys. Chem. 2020, 21(12) 1224-1229
Okuno, Y., Szabo, A., Clore, G. M. Quantitative interpretation of solvent paramagnetic relaxation for probing protein–cosolute interactions. J. Am. Chem. Soc. 2020, 142 (18) 8181-8290
2019
Okuno, Y., Mecha, M. F., Cavagnero, S. Laser-and cryogenic probe-assisted NMR enables hypersensitive analysis of biomolecules at submicromolar concentration, Proc. Natl. Acad. Sci. 116 (24), 11602-11611
2018
Varela, A. E., Lang, J. F., Wu, Y., Dalphin M.D. , Stangl, A. J., Okuno, Y., Cavagnero, S., Kinetic trapping of folded proteins relative to aggregates under physiologically relevant conditions. J. Phys. Chem. B. 2018, 122, 7682-7698
Okuno. Y., Cavagnero, S.,Effect of heavy atoms on photochemically induced dynamic nuclear polarization in liquids, J. Magn. Reson. 2018, 286, 172-187
2017
Okuno, Y., Cavagnero, S., Photochemically induced dynamic nuclear polarization: Basic principles and applications, eMagRes. 2017, 283-314
2016
Okuno, Y., Cavagnero, S., Fluorescein: A photo-CIDNP sensitizer enabling hypersensitive NMR data collection in liquids at low micromolar concentration. J. Phys. Chem. B 2016, 120 (4), 715–723
2015
Lee, J. H., Zhang, D., Hughes, C., Okuno, Y., Sekhar, A., Cavagnero, S. Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone. Proc. Natl. Acad. Sci. USA 2015, 112 (31), E4206-E4215
2014
Lee, J. H., Okuno, Y., Cavagnero, S. Sensitivity enhancement in solution NMR: Emerging ideas and new frontiers. J. Magn. Reson. 2014, 241, 18-31
Honda, M.; Okuno, Y., Hengel, S. R., Martín-López, J. V., Cook, C. P., Amunugama, R., Soukup, R. J., Subramanyam, S., Fishel, R., Spies, M. Mismatch repair protein hMSH2–hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate. Proc. Natl. Acad. Sci. USA 2014, 111 (3), E316-E325
2011
Honda, M., Okuno, Y., Yoo, J., Ha, T., Spies, M. Tyrosine phosphorylation enhances RAD52‐mediated annealing by modulating its DNA binding. EMBO J. 2011, 30 (16), 3368-3382
2010
Grimme, J. M., Honda, M., Wright, R., Okuno, Y., Rothenberg, E., Mazin, A. V., Ha, T., Spies, M. Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes. Nucleic Acids Res. 2010, 38 (9), 2917-2930