Current Research
Corey is investigating the role of central carbon metabolism in the regulation of bacterial growth and morphology.
Publications
Mueller, E. A. and C. S. Westfall (2019) Blown out of proportion — The role of ppGpp in balanced metabolism. Small Things Considered Blog, March 11, 2019. Link is here.
Westfall, C. S., A. L. Flores-Mireles, J. I. Robinson, A. J. L. Lynch, S. Hultgren, J. P. Henderson, and P. A. Levin (2019) The widely used antimicrobial triclosan induces high levels of antibiotic tolerance in vitro and reduces antibiotic efficacy up to 100-fold in vivo. Antimicrob Agents Chemother. doi: 10.1128/AAC.02312-18. PMID:30782996
Westfall, C. S. (2018) An “Uncommon” Role for Cyclic Enterobacterial Common Antigen in Maintaining Outer Membrane Integrity, mBio, mBio Oct 2018, 9 (5) e02162-18; DOI: 10.1128/mBio.02162-18 PMID: 30377288
Westfall, C. S. and P. A. Levin (2018) Comprehensive analysis of central carbon metabolism reveals multiple connections between nutrients, biosynthetic capacity, and cell morphology in Escherichia coli, PLOS Genetics, 14(2) e1007205. doi.org/10.1371/journal.pgen.1007205
Westfall, C. S. and P. A. Levin (2017) Bacterial Cell Size: Multifactorial and Multifaceted, Invited review for Annual Review of Microbiology, 71: 499-517. PMID: 28886685 DOI: 10.1146/annurev-micro-090816-093803
Korasick D.A., Westfall C.S., Lee S.G., Nanao M.H., Dumas R., Hagen G., Guilfoyle T.J., Jez J.M., Strader L.C. (2014) Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression. PNAS. 111:5427-5432.
Herrmann J., Ravilious G.E., McKinney S.E., Westfall C.S., Lee S.G., Baraniecka P., Giovannetti M., Kopriva S., Krishnan H.B., Jez J.M. (2014) Structure and mechanism of soybean ATP sulfurylase and the committed step in plant sulfur assimilation. J Biol Chem. 289:10919-10929.
Round A., Brown E., Marcellin R., Kapp U., Westfall C.S., Jez J.M., Zubieta C. (2013) Determination of the GH3.12 protein conformation through HPLC-integrated SAXS measurements combined with X-ray crystallography. Acta Crystallogr D. 69:2072-2080.
Choudhury S.R., Westfall C.S., Hackenberg D., Pandey S. (2013) Measurement of GTP-binding and GTPase activity of heterotrimeric Gɑ proteins. Methods Mol Biol. 1043:13-20.
Ravilious G.E., Herrmann J., Goo Lee S., Westfall C.S., Jez J.M. (2013) Kinetic mechanism of the dimeric ATP sulfurylase from plants. Biosci Rep. 33:4.
Westfall C.S., Muehler A.M., Jez J.M. (2013) Enzyme action in the regulation of plant hormone response. J Biol Chem. 288:19304-19311.
Ravilious G.E., Westfall C.S., Jez J.M. (2013) Redox-linked gating of nucleotide binding by the N-terminal domain of adenosine 5’-phosphosulface kinase. J Biol Chem. 288:6107-6115.
Choudhury S.R., Westfall C.S., Pandey S. (2012) The RGS proteins add to the diversity of soybean heterotrimeric G-protein signaling. Plant Signal Behav. 7:1114-1117.
Li Y., Macdonald-Obermann J., Westfall C., Piwnica-Worms D., Pike L.J. (2012) Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization. J Biol Chem. 287:31116-31125.
Westfall C.S.*, Zubieta C.*, Herrmann J., Kapp U., Nanao M.H., Jez J.M. (2013) Structural basis for prereceptor modulation of plant hormones by GH3 proteins. Science 336:1708-1711. (* co-first authors)
Choudhury S.R., Westfall C.S., Laborde J.P., Bisht N.C., Jez J.M., Pandey S. (2012) Two chimeric regulators of G-protein signaling (RGS) proteins differentially modulate soybean heterotrimeric G-protein cycle. J Biol Chem 287:17870-17881.
Westfall C.S., Herrmann J., Chen Q., Wang S., Jez J.M. (2010) Modulating plant hormones by enzyme action: the GH3 family of acyl acid amido synthetases. Plant Signal Behav. 5:1607-1612.
Chen Q., Westfall C.S., Hicks L.M., Wang S., Jez J.M. (2010) Kinetic basis for the conjugation of auxin by a GH3 family indole-acetic acid-amido synthetase. J Biol Chem. 285:29780-29786.