Publications

  1. Gupta D, Sutherland MC, Rengasamy K, Meacham JM, Kranz RG, Bose A.  Photoferrotrophs Produce a PioAB Electron Conduit for Extracellular Electron Uptake.  mBio. 2019 Nov 5;10(6). pii: e02668-19. doi: 10.1128/mBio.02668-19.PMID: 31690680
  1. Sutherland MC, Jarodsky JM, Ovchinnikov S, Baker D, Kranz RG.  Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis.  Journal of Molecular Biology. 2018; 430(8):1065-1080. NIHMSID: NIHMS952326  PMID: 29518410 PMCID: PMC5889519 (A commentary by Iqbal Hamza on this achievement was commissioned by the JMB editor)
  1. Sutherland MC, Tran NL, Tillman DE, Jarodsky JM, Yuan J, Kranz RG. Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase. mBio. 2018 Dec 18;9(6). pii: e02134-18. doi: 10.1128/mBio.02134-18.PMID:30563894
  1. Babbitt SE, Hsu J, Mendez DL, Kranz RG. 2017.  Biosynthesis of Single Thioether c-Type Cytochromes Provides Insight into Mechanisms Intrinsic to Holocytochrome c Synthase (HCCS).  Biochemistry. 2017 Jul 5;56(26):3337-3346. doi: 10.1021/acs.biochem.7b00286. Epub 2017 Jun 26.  PMID: 28617588
  1. Mendez DL, Akey IV, Akey CW, Kranz RG.  2017.  Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro. Biochemistry. 2017 Jun 6;56(22):2766-2769. doi: 10.1021/acs.biochem.7b00309. Epub 2017 May 19.  PMID: 28510448
  1. Mendez DL, Babbitt SE, King JD, D’Alessandro J, Watson MB, Blankenship RE, Mirica LM, Kranz RG. 2017.  Engineered holocytochrome c synthases that biosynthesize new cytochromes c.  Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2235-2240. doi: 10.1073/pnas.1615929114. Epub 2017 Feb 14.  PMID: 28196881
  1. Babbitt SE, Hsu J, Kranz RG. 2016.  Molecular Basis Behind Inability of Mitochondrial Holocytochrome c Synthase to Mature Bacterial Cytochromes: DEFINING A CRITICAL ROLE FOR CYTOCHROME c α HELIX-1. J Biol Chem. 2016 Aug 19;291(34):17523-34. doi: 10.1074/jbc.M116.741231. Epub 2016 Jul 6. PMID: 27387500.
  1. Sutherland MC, Rankin JA, Kranz RG. 2016.  Heme Trafficking and Modifications during System I Cytochrome c Biogenesis: Insights from Heme Redox Potentials of Ccm Proteins.  Biochemistry. 2016 Jun 7;55(22):3150-6. doi: 10.1021/acs.biochem.6b00427. Epub 2016 May 26. PMID: 27198710.
  1. Babbitt SE, Sutherland MC, Francisco BS, Mendez DL, Kranz RG.  2015 Mitochondrial cytochrome c biogenesis: no longer an enigma. Trends Biochem Sci. 2015.  Aug;40(8):446-55.  Review.  PMID: 26073510.  PMCID: PMC4509832.
  1. Babbitt SE, San Francisco B, Mendez DL, Lukat-Rodgers GS, Rodgers KR, Bretsnyder EC, Kranz RG.  2014. Mechanisms of Mitochondrial Holocytochrome c Synthase and the Key Roles Played by Cysteines and Histidine of the Heme Attachment Site, Cys-XX-Cys-His.  J Biol Chem. Oct 17;289(42):28795-807.  PMID: 25170082.  PMCID: PMC4200240.
  1. Babbitt SE, San Francisco B, Bretsnyder EC, Kranz RG. 2014.  Conserved residues of the human mitochondrial holocytochrome c synthase mediate interactions with heme.  Biochemistry. 2014 Aug 19;53(32):5261-71. PMID: 25054239.  PMCID: PMC4139152.
  1. San Francisco B, Sutherland MC, Kranz RG.  2014.  The CcmFH complex is the system I holocytochrome c synthetase: engineering cytochrome c maturation independent of CcmABCDE.    Mol Microbiol. Mar;91(5):996-1008. PMID: 24397552. PMCID: PMC3959880
  1. San Francisco Band Kranz RG. 2014.  Interaction of HoloCcmE with CcmF in Heme Trafficking and Cytochrome c Biosynthesis. J Mol Biol, Feb 6;426(3):570-85. PMID: 24513106 PMCID: PMC3943652.
  2. San Francisco B, Bretsnyder EC and Kranz RG. 2013. Human mitochondrial holocytochrome c synthase’s heme binding, maturation determinants, and complex formation with cytochrome c. Proc Natl Acad Sci Plus USA. Feb 26;110(9):E788-97. PMID: 23150584.  PMCID: PMC3587199.