Meredith Jackrel graduated from the College of New Jersey with a BS in Chemistry in 2004. She then attended Yale University where she joined Lynne Regan’s laboratory in the Departments of Molecular Biophysics & Biochemistry and Chemistry. There she studied protein – protein interactions. Her work focused on tetratricopeptide repeat (TPR) proteins and she designed new protein – peptide binding pairs. She also developed a split-GFP reassembly assay. Meredith received her Ph.D. in Chemistry in 2010.
In 2010, Meredith joined James Shorter’s laboratory in the Department of Biochemistry and Biophysics at the Perelman School of Medicine at the University of Pennsylvania as a postdoctoral fellow. There she developed techniques to re-engineer the protein disaggregase, Hsp104, to counter protein misfolding implicated in ALS and Parkinson’s disease. Meredith won American Heart Association Postdoctoral Fellowships in 2011 and 2013. In 2014 Meredith was awarded a Target ALS Springboard Fellowship to support her transition to an independent faculty position.
In 2017, Meredith became an Assistant Professor at Washington University in the Department of Chemistry.