Darcy Harris

Darcy is a graduate student in the lab. She works jointly with the Rudra lab and is in the Biochemistry, Biophysics & Structural Biology program. In 2024, Darcy was awarded a National Science Foundation Graduate Research Fellowship (NSF-GRFP)! Darcy is from Pottstown, Pennsylvania and graduated from Franklin & Marshall College in 2020 with a BA in Biochemistry & Molecular Biology. After college, she worked for two years as a post-baccalaureate fellow at NIAID. Outside of the lab, Darcy enjoys baking, reading, and chilling with her cat.


Liu, C, Wang, L, Shi, W, Merriam, J, Yang, ES, Zhang, Y, Chen, M, Kong, W-P, Cheng, C, Tsybovsky, Y, Stephens, T, Verardi, R, Leung, K, Stein, C, Olia, AS, Harris, DR, Graham, BS, Kwong, PD, Pegu, A, Koup, RA, Mascola, JR. Potent and Durable Neutralizing Antibody Responses Elicited by Gene Delivery of Self-Assembling SARS-CoV-2 Spike HBsAg Nanoparticles. Accepted at npj Vaccines.

Olia, AS, Cheng, C, Zhou, T, Biju, A, Harris, DR, Changela, A, Duan, H, Ivleva, VB, Kong, W-P, Ou, L, Rawi, R, Tsybovsky, Y, Van Wazer, DJ, Corrigan, AR, Gonelli, CA, Lee, M, McKee, K, Narpala, S, O’Dell, S, Parchment, DK, Stancofski, E-SD, Stephens, S, Tan, I, Teng, I-T, Wang, S, Yang, Y, Zhang, B, VRC Production Program, Doria-Rose, NA, Koup, RA, McDermott, AB, Gall, JG, Lei, QP, Mascola, JR, Kwong, PD. Soluble Prefusion-Closed HIV-Envelope Trimers with Glycan-Covered Bases Reveal Glycans Can Mask the Base but May Destabilize the Trimer. Accepted at iScience. 

Andrews, SF, Cominsky, LY, Shimberg, GD, Gillespie, RA, Gorman, J, Raab, JE, Brand, J, Creanga, A, Gajjala, SR, Narpala, S, Cheung, CSF, Harris, DR, Zhou, T, Gordon, I, Holman, L, Mendoza, F, Houser, KV, Chen, GL, Mascola, JR, Graham, BS, Kwong, PD, Widge, A, Dropulic, LK, Ledgerwood, JE, Kanekiyo, M, McDermott, AB. An Influenza Hemagglutinin Stem-only Immunogen Elicits a Broadly Cross-Reactive B Cell Response in Humans. Sci Transl Med. 15(692):eade4976. 

Chonira, V, Kwon, YD, Gorman, J, Case, JB, Ku, Z, Simeon, R, Casner, RG, Harris, DR, Olia, AS, Stephens, T, Shapiro, L, Bender, MF, Boyd, H, Teng, I-T, Tsybovsky, Y, Krammer, F, Zhang, N, Diamond, MS, Kwong, PD, An, Z, Chen, Z. (2023). A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat Chem Biol. 19(3):284-291. 

Cheung, CS-F, Gorman, J, Andrews, SF, Rawi, R, Reveiz, M, Shen, C-H, Wang, Y, Harris, DR, Nazzari, AF, Olia, AS, Raab, J, Teng, I-T, Verardi, R, Wang, S, Chuang, G-Y, McDermott, AB, Zhou, T, Kwong, PD. (2022). Structure of an Influenza Pan-Group 2 Neutralizing Antibody Targeting the Hemagglutinin Stem Supersite. Structure. S0969-2126(22)00130-7. 

Gagne, M, Moliva, JI, Foulds, KE, Andrew, SF, Flynn, BJ, Werner, AP, Wagner, DA, Teng, I-T, Lin, BC, Moore, C, Jean-Baptiste, N, Carroll, R, Foster, SL, Patel, M, Ellis, M, Edara, V-V, Vargas Maldonado, N, Minai, M, McCormick, L, Honeycutt, CC, Nagata, BM, Bock, KW, Dulan, CNM, Cordon, J, Flebbe, DR, Todd, J-PM, McCarthy, E, Pessaint, L, Van Ry, A, Narvaez, B, Valentin, D, Cook, A, Dodson, A, Steingrebe, K, Nurmukhambetova, ST, Godbole, S, Henry, AR, Laboune, F, Roberts-Torres, J, Lorang, CG, Amin, S, Trost, J, Naisan, M, Basappa, M, Willis, J, Wang, L, Shi, W, Doria-Rose, NA, Zhang, Y, Yang ES, Leung, K, O’Dell, S, Schmidt, SD, Olia, AS, Liu, C, Harris, DR, Chuang, G-Y, Stewart-Jones, G, Renzi, I, Lai, Y-T, Malinowski, A, Wu, K, Mascola, JR, Carfi, A, Kwong, PD, Edwards, DK, Lewis, MG, Andersen, H, Corbett, KS, Nason, MC, McDermott, AB, Suthar, MS, Moore, IN, Roederer, M, Sullivan, NJ, Douek, DC, Seder, RA. (2022). mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron. Cell. 185(9):1556-1571.e18. 

Zhou, T, Wang, L, Misasi, J, Pegu, A, Zhang, Y, Harris, DR, Olia, AS, Talana, CA, Yang, ES, Chen, M, Choe, M, Shi, W, Teng, I-T, Creanga, A, Jenkins, C, Leung, K, Liu, T, Stancofski, E-SD, Stephens, T, Zhang, B, Tsybovsky, Y, Mascola, JR, Sullivan, NJ, Kwong, PD (2022). Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529. Science. 376(6591):eabn8897. 

Andrews, SF, Raab, JE, Gorman, J, Gillespie, RA, Cheung, CS-F, Rawi, R, Cominsky, LY, Boyington, JC, Creanga, A, Shen, C-H, Harris, DR, Olia, AS, Nazzari, AF, Zhou, T, Houser, KV, Chen, GL, Mascola, JR, Graham, BS, Kanekiyo, M, Ledgerwood, JE, Kwong, PD, McDermott, AB. (2022). A single residue in influenza virus H2 hemagglutinin enhances breadth of the B cell response elicited by H2 vaccination. Nat Med. 28(2):373-382.

Olenginski, GM, Piacentini, J, Harris, DR, Runko, NA, Alter, JR, Hess, KR, Brewer, SH, and Phillips-Piro,CM. (2021). Structural and spectrophotometric investigation of two unnatural amino-acid altered chromophores in the superfolder green fluorescent protein. Acta Crystallogr D Struct Biol. 77(Pt 8):1010-1018.

Lin, BC, Harris, DR, Kirkman, LMD, Perez, AM, Qian, Y, Schermerhorn, JT, Hong, MY, Winston, DS, Xu, L, Brandt, GS. (2017). FIKK kinase, a Ser/Thr kinase essential to malaria parasites, is inhibited by tyrosine kinase inhibitors. ACS Omega. 2(10):6605-6612. 

Lin, BC, Harris, DR, Kirkman, LMD, Perez AM, Qian, Y, Schermerhorn, JT, Hong, MY, Winston, DS, Xu, L, Lieber, AM, Hamilton, M, Brandt, GS. (2017). The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparumBioorg Chem. 75:217-223.

Fuller-Espie, SL, Harris, DR, Daly, JH, and Jakeman, JM. Optimization of Cell Culture Conditions for the Earthworm Eisenia hortensis: (2015). A Study Investigating the Effects of Media, Carbon Dioxide, Temperature, Serum, and Anti-Fungal Agents. J Pa Acad Sci. 89(2):57-68.