Anuradhika is a postdoctoral fellow in the lab. She joined the lab in 2021 and in 2022 she was awarded the two-year ALS Association’s Milton Safenowitz Postdoctoral Fellowship. She is originally from Himachal Pradesh, India. She graduated with a degree in Biotechnology from Panjab University, Chandigarh. She then completed her PhD at the Institute of Microbial Technology (IMTECH) in Chadigarh, India where she worked in Dr. Deepak Sharma’s lab. There she focused on studying the yeast prions [URE3] and [PSI+] using a range of molecular genetics, biochemical, and biophysical techniques. When not in the lab, she enjoys listening to music, cooking, and watching movies.
Publications
Chen S, Puri A, Bell B, Fritsche J, Palacios HH, Balch M, Sprunger ML, Howard MK, Ryan JJ, Haines JN, Patti GJ, Davis AA, and Jackrel ME (2024). HTRA1 disaggregates α-synuclein amyloid fibrils and coverts them into non-toxic and seeding incompetent species. Nat. Commun. 15: 2436. link
Kim, Y., Li C., Gu C., Tycksen E., Puri A., Pietka T.A., Sivapackiam J., Fang Y., Kidd K., Park S., Johnson B.G., Kmoch S., Duffield J.S., Bleyer A.J., Jackrel M.E., Urano F., Sharma V., Lindahl M, and Chen Y.F. (2023). MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy. BioRxiv. pdf file link
Sharma, V., Jahan, K., Kumar, P., Puri, A., Sharma, V.K., Mishra, A., Bharatam, P.V., Sharma, D., Rishi, V., and J. Roy. (2022). Mechanistic insights into granule-bound starch synthase I (GBSSI.L539P) allele in high amylose starch biosynthesis in wheat (Triticum aestivum L.). Funct Integr Genomics. 23(1):20. doi: 10.1007/s10142-022-00923-y.
Puri, A., Singh, P., Kumar, N., Kumar, R., and D. Sharma. (2021). Tah1, a key component of R2TP complex that regulates assembly of snoRNP, is involved in de novo generation and maintenance of yeast prion [URE3]. J Mol Biol. 433(13):166976. doi: 10.1016/j.jmb.2021.166976.
Singh, P., Unik, B., Puri, A., Nagpal, G., Singh, B., Gautam, A., and D. Sharma. (2020). HSPMdb: a computational repository of heat shock protein modulators. Database (Oxford). doi: 10.1093/database/baaa003.
Gupta, A., Puri, A., Singh, P., Sonam, S., Pandey, R., and D. Sharma. (2018). The yeast stress inducible Ssa Hsp70 reduces alpha-synuclein toxicity by promoting its degradation through autophagy. PLoS Genet. 14(10):e1007751. doi: 10.1371/journal.pgen.1007751.
Kumar, N., Gaur, D., Gupta, A., Puri, A., and D. Sharma. (2015). Hsp90-associated immunophilin homolog Cpr7 is required for the mitotic stability of [URE3] prion in Saccharomyces cerevisiae. PLoS Genet. 11(10):e1005567. doi: 10.1371/journal.pgen.1005567.