Welcome to the Huang Lab!

We study the neural mechanisms of learning and memory using state-of-the-art in vivo voltage imaging

Spike propagation within axonal branches of a fly CNS neuron. Voltage indicator: pAce. Imagine rate: 1k Hz.
Bottom left, Video of a fly running on a trackball under the microscope objective during voltage imaging of the fly’s neural activity. Bottom right, Time traces of the fly’s forward running speed and rotational speed on the trackball. Top left, Voltage-imaging movie, recorded simultaneously with the behavioral video, showing the fluorescence changes of the Ace2N-mNeon-v2 voltage indicator in a pair of MBON-γ1pedc>ɑ/β neurons located in opposite hemispheres of the fly brain. Top right, Fluorescence traces and spike raster plots show the spiking dynamics of the two MBON-γ1pedc>ɑ/β neurons.
Learn more about our research

Selected publications

Dopamine-mediated interactions between short- and long-term memory dynamics

Dopamine-mediated interactions between short- and long-term memory dynamics

Cheng Huang*,†, Junjie Luo†, Seung Je Woo, Lucas Roitman, Jizhou Li, Vincent Pieribone, Madhuvanthi Kannan*, Ganesh Vasan*, and Mark J. Schnitzer*. Nature 634 (2024): 1141–1149. (†Equal contribution, *Corresponding author).

Wide-field fluorescence lifetime imaging of neuron spiking and sub-threshold activity in vivo

Wide-field fluorescence lifetime imaging of neuron spiking and sub-threshold activity in vivo

Adam J Bowman, Cheng Huang, Mark J Schnitzer, and Mark A Kasevich. Science 380 (2023): 1270-1275.

Dual polarity voltage imaging reveals subthreshold dynamics and concurrent spiking patterns of multiple neuron-types

Dual polarity voltage imaging reveals subthreshold dynamics and concurrent spiking patterns of multiple neuron-types

Madhuvanthi Kannan, Ganesh Vasan, Simon Haziza, Cheng Huang, Radoslaw Chrapkiewicz, Junjie Luo, Jessica A. Cardin, Mark J. Schnitzer, and Vincent A. Pieribone. Science 378 (2022): eabm8797.

Long-term optical brain imaging in live adult fruit flies

Long-term optical brain imaging in live adult fruit flies

Cheng Huang*, Jessica R Maxey, Supriyo Sinha, Joan Savall, Yiyang Gong, and Mark J. Schnitzer*. Nature Communications 9 (2018): 872. (*Corresponding author)

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