Our laboratory studies the genetics and pathogenesis of benign and malignant human diseases with a focus on the kidney. Our goal is to improve the diagnosis and therapies for these diseases. We have been creating and studying an array of experimental and disease models in cells, organoids, and mice to study the involvement of important pathways in the pathogenesis of kidney diseases and cancer. We use a multi-disciplinary approach, including cutting edge omics and imaging technologies, to study the mechanisms leading from genetic changes to disease initiation and progression. In addition to answering specific questions with clinical relevance, we are also keen on developing new enabling tools for the research community. We are heavily involved in multiple large scale NIH consortia, including HTAN, PDXNet, CPTAC, SenNet, and GUDMAP to use multi-omics and advanced imaging technologies to study disease etiology and treatment, as well as building reference databases and atlases for the research community.
We have close collaboration with the Ding Lab in these and other projects: https://dinglab.wustl.edu/