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Our research focuses on the cytoskeletal machinery for cell morphogenesis. We want to know how microtubules become dynamically patterned into specific arrays and how these arrays guide cell wall deposition to impart cell shape. Our work uses a synergistic combination of live imaging, in vitro reconstitution at single-molecule resolution, molecular genetics and computational modeling. This multidisciplinary approach has allowed us to discover new components and mechanisms underlying the complex and multi-scale process linking microtubule dynamics and organization to cell shape determination.

Latest Lab News

Ram’s perspective published in Plant Cell

Ram’s perspective on the cortical microtubule cytoskeleton as a mechanosensory apparatus is part of the  “Fifteen compelling open questions in plant cell biology”, published by The Plant Cell.

Cellular Transformations book published!

Ram and Sung Ho Kim’s book based on their Cellular Transformations course is published! This book highlights how the confluence of biology and architecture can be used to develop new solutions to address real-world problems.

We are part of the NSF-funded Science and Technology Center for Engineering Mechanobiology (https://cemb.upenn.edu/) which seeks to understand how mechanical forces impact biology at molecular, cellular and tissue scales.

Contact Us

Contact us at:
Biology Department
Washington University in St. Louis
1 Brookings Dr, CB 1137
St. Louis, MO 63130.
Lab phone: (314) 935 9080