Welcome to the Dixit Lab website! Our research is motivated by the spectacular diversity of cell shapes in nature. We want to know how different cell types acquire characteristic shapes and how hormones and mechanical stimuli alter cell shape to guide growth and development. We use plants as a model system to study how microtubules become dynamically patterned into specific configurations that determine cell morphology by spatially organizing the rigid cell wall. Our work uses a synergistic combination of live imaging, in vitro reconstitution at single-molecule resolution, molecular genetics and computational modeling. This multidisciplinary approach has allowed us to discover new components and mechanisms underlying the complex and multi-scale process linking microtubule dynamics and organization to cell shape determination.
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We are part of the NSF-funded Science and Technology Center for Engineering Mechanobiology (https://cemb.upenn.edu/) which seeks to understand how mechanical forces impact biology at molecular, cellular and tissue scales.
Contact us at:
Washington University in St. Louis
1 Brookings Dr, CB 1137
St. Louis, MO 63130.
Lab phone: (314)-935 9080