Welcome to the Dixit Lab website! Our research is motivated by the spectacular diversity of cell shapes in nature. We want to know how different cell types acquire characteristic shapes and how hormones and mechanical stimuli alter cell shape to guide growth and development. We use plants as a model system to study how microtubules become dynamically patterned into specific configurations that determine cell morphology by spatially organizing the rigid cell wall. Our work uses a synergistic combination of live imaging, in vitro reconstitution at single-molecule resolution, molecular genetics and computational modeling. This multidisciplinary approach has allowed us to discover new components and mechanisms underlying the complex and multi-scale process linking microtubule dynamics and organization to cell shape determination.

Latest Lab News

Two postdoctoral research positions available in the Dixit Lab

Two NIH-funded postdoctoral research positions are available immediately to study new mechanisms that regulate the microtubule severing activity of katanin and to develop a microfluidics platform to study how biochemical and biophysical mechanisms together influence microtubule array organization. NIH Funding is available for 5 years for each position, with the expectation that the candidates will […]

We are part of the NSF-funded Science and Technology Center for Engineering Mechanobiology (https://cemb.upenn.edu/) which seeks to understand how mechanical forces impact biology at molecular, cellular and tissue scales.

Contact Us

Contact us at:
Biology Department
Washington University in St. Louis
1 Brookings Dr, CB 1137
St. Louis, MO 63130.
Lab phone: (314)-935 9080