(click on paper title to go the Pubmed entry for that paper)

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.

Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A.

JCI Insight. 2019 Sept 5


Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.

Russo A, DiAntonio A.

Cell Rep. 2019 Sep 3


TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.

Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT.

Science. 2019 Aug 23


DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.

Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A.

Neurobiol Dis. 2019 July


Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

DiAntonio A.

Pain. 2019 May


The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.

Russo A, Goel P, Brace EJ, Buser C, Dickman D, DiAntonio A.

EMBO Rep. 2019 March


Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.

Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J.

J Exp Med. 2019 Jan 14


HSP90 is a chaperone for DLK and is required for axon injury signaling.

Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A.

Proc Natl Acad Sci U S A. 2018 Oct 1


Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.

Summers DW, Milbrandt J, DiAntonio A. 

Proc Natl Acad Sci U S A. 2018 Aug 27


Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J.

Curr Biol. 2018 Feb 5


The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J.

Neuron. 2017 Mar 22


MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

Walker LJ, Summers DW, Sasaki Y, Brace EJ, Milbrandt J, DiAntonio A.

Elife. 2017 Jan 17


Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A.

Brain. 2016 Dec


NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J.

Elife. 2016 Oct 13


SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.

Summers DW, Gibson DA, DiAntonio A, Milbrandt J.

Proc Natl Acad Sci U S A. 2016 Oct 11


SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.

Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A.

Neurobiol Dis. 2015 May


Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.

Brace EJ, Wu C, Valakh V, DiAntonio A.

J Neurosci. 2014 Jun 18


Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J.

J Neurosci. 2013 Aug 14


Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A.

Cell Rep. 2013 May 30


Shin JE, Miller BR, Babetto E, Cho Y, Sasaki Y, Qayum S, Russler EV, Cavalli V, Milbrandt J, DiAntonio A.

Proc Natl Acad Sci U S A. 2012 Dec 26


Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A.

Neuron. 2012 Jun 21


Graf ER, Daniels RW, Burgess RW, Schwarz TL, DiAntonio A.

Neuron. 2009 Dec 10


Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A.

Nat Neurosci. 2009 Apr