(click on paper title to go the Pubmed entry for that paper)
Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.
Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A.
JCI Insight. 2019 Sept 5
Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.
Russo A, DiAntonio A.
Cell Rep. 2019 Sep 3
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.
Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT.
Science. 2019 Aug 23
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.
Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A.
Neurobiol Dis. 2019 July
Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.
DiAntonio A.
Pain. 2019 May
The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.
Russo A, Goel P, Brace EJ, Buser C, Dickman D, DiAntonio A.
EMBO Rep. 2019 March
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.
Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J.
J Exp Med. 2019 Jan 14
HSP90 is a chaperone for DLK and is required for axon injury signaling.
Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A.
Proc Natl Acad Sci U S A. 2018 Oct 1
Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.
Summers DW, Milbrandt J, DiAntonio A.
Proc Natl Acad Sci U S A. 2018 Aug 27
Frey E, Karney-Grobe S, Krolak T, Milbrandt J, DiAntonio A.
eNeuro. 2018 May 30
Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J.
Curr Biol. 2018 Feb 5
Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J.
Neuron. 2017 Mar 22
Walker LJ, Summers DW, Sasaki Y, Brace EJ, Milbrandt J, DiAntonio A.
Elife. 2017 Jan 17
Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.
Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A.
Brain. 2016 Dec
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.
Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J.
Elife. 2016 Oct 13
Summers DW, Gibson DA, DiAntonio A, Milbrandt J.
Proc Natl Acad Sci U S A. 2016 Oct 11
SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J.
Science. 2015 Apr 24
Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A.
Neurobiol Dis. 2015 May
Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.
Summers DW, DiAntonio A, Milbrandt J.
J Neurosci. 2014 Jul 9
Brace EJ, Wu C, Valakh V, DiAntonio A.
J Neurosci. 2014 Jun 18
Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J.
J Neurosci. 2013 Aug 14
Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A.
Cell Rep. 2013 May 30
Shin JE, Miller BR, Babetto E, Cho Y, Sasaki Y, Qayum S, Russler EV, Cavalli V, Milbrandt J, DiAntonio A.
Proc Natl Acad Sci U S A. 2012 Dec 26
Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A.
Neuron. 2012 Jun 21
Graf ER, Daniels RW, Burgess RW, Schwarz TL, DiAntonio A.
Neuron. 2009 Dec 10
Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A.
Nat Neurosci. 2009 Apr