(click on paper title to go the Pubmed entry for that paper)
Multiple domain interfaces mediate SARM1 autoinhibition.
Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J.Proc Natl Acad Sci U S A. 2021 Jan 26
Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.
Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R. Cell Rep. 2021 Jan 5
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration.
Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N, Dong Z, Lin JB, Boye SL, DiAntonio A, Boye SE, Apte RS, Milbrandt J. Elife. 2020 Oct 27
SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.
Ko KW, Milbrandt J, DiAntonio A. J Cell Biol. 2020 Aug 3
Domain-centric database to uncover structure of minimally characterized viral genomes.
Sci Data. 2020 Jun 25
Models of Axon Degeneration in Drosophila Larvae.
Methods Mol Biol. 2020
The SARM1 axon degeneration pathway: control of the NAD+metabolome regulates axon survival in health and disease.
Curr Opin Neurobiol. 2020 Apr 17
cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.
Exp Neurol. 2020 July
SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+and water.
Li H, Russo A, DiAntonio A. J Cell Biol. 2019 Dec 2.
DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration.
Summers DW, Frey E, Walker LJ, Milbrandt J, DiAntonio A. Mol Neurobiol. 2019 Nov 7.
Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.
Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A. JCI Insight. 2019 Sept 5
Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.
Russo A, DiAntonio A.Cell Rep. 2019 Sep 3
TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.
Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT. Science. 2019 Aug 23
DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.
Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A. Neurobiol Dis. 2019 July
Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.
DiAntonio A. Pain. 2019 May
The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.
Russo A, Goel P, Brace EJ, Buser C, Dickman D, DiAntonio A. EMBO Rep. 2019 March
Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.
Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J.J Exp Med. 2019 Jan 14
HSP90 is a chaperone for DLK and is required for axon injury signaling.
Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A. Proc Natl Acad Sci U S A. 2018 Oct 1
Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.
Summers DW, Milbrandt J, DiAntonio A. Proc Natl Acad Sci U S A. 2018 Aug 27
TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.
Frey E, Karney-Grobe S, Krolak T, Milbrandt J, DiAntonio A. eNeuro. 2018 May 30
TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.
Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J. Curr Biol. 2018 Feb 5
Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J. Neuron. 2017 Mar 22
Walker LJ, Summers DW, Sasaki Y, Brace EJ, Milbrandt J, DiAntonio A. Elife. 2017 Jan 17
Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.
Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A. Brain. 2016 Dec
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.
Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. Elife. 2016 Oct 13
Summers DW, Gibson DA, DiAntonio A, Milbrandt J. Proc Natl Acad Sci U S A. 2016 Oct 11
SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J. Science. 2015 Apr 24
Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A. Neurobiol Dis. 2015 May
Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.
Summers DW, DiAntonio A, Milbrandt J. J Neurosci. 2014 Jul 9
Brace EJ, Wu C, Valakh V, DiAntonio A. J Neurosci. 2014 Jun 18
Sarm1-mediated axon degeneration requires both SAM and TIR interactions.
Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J. J Neurosci. 2013 Aug 14
The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.
Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A. Cell Rep. 2013 May 30
SCG10 is a JNK target in the axonal degeneration pathway.
Shin JE, Miller BR, Babetto E, Cho Y, Sasaki Y, Qayum S, Russler EV, Cavalli V, Milbrandt J, DiAntonio A. Proc Natl Acad Sci U S A. 2012 Dec 26
Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.
Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A. Neuron. 2012 Jun 21
Rab3 dynamically controls protein composition at active zones.
Graf ER, Daniels RW, Burgess RW, Schwarz TL, DiAntonio A. Neuron. 2009 Dec 10
A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration.
Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A. Nat Neurosci. 2009 Apr