Publications
Postdoctoral (2017-2022)
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Engineering circular RNA for enhanced protein production
Nature Biotechnology
July 2022
Chen R., Wang S.K., Belk J.A., Amaya L., Li Z., Cardenas A., Abe B.T., Chen C.-K., Wender P.A., and Chang H.Y.
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The role of circular RNAs in pulmonary hypertension
European Respiratory Journal
December 2022
Ali M.K., Schimmel K., Zhao L., Chen C.-K., Dua K., Nicolls M.R., and Spierkerkoetter E.
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Noncoding RNAs: Biology and applications – A Keystone Symposia report
Annals of the New York Academy of Science
December 2021
Cable J., Heard E., Hirose T., Prasanth K.V., Chen L.L., Henninger J.E., Quinodoz S.A., Spector D.L., Diermeier S.D., Porman A.M., Kumar D., Feinberg M.W., Shen X., Unfried J.P., Johnson R., Chen C.-K., Wilusz J.E., Lempradl A., McGeary S.E., Wahba L., Pyle A.M., Hargrove A.E., Simon M.D., Marcia M., Przanowska R.K., Chang H.Y., Jaffrey S.R., Contreras L.M., Chen Q., Shi J., Mendell J.T., He L., Song E., Rinn J.L., Lalwani M.K., Kalem M.C., Chuong E.B., Maquat L.E., and Liu X.
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Structured elements drive extensive circular RNA translation
Molecular Cell
October 2021
Chen C.-K., Cheng R., Demeter J., Chen J., Weingarten-Gabbay S., Jiang L., Snyder M.P., Weissman J.S., Segal E., Jackson P.K., and Chang H.Y.
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A protein assembly mediates Xist localization and gene silencing
Nature
September 2020
Pandya-Jones A., Markaki Y., Serizay J., Chitiashvili T., Leon W.R.M., Damianov A., Chronis C., Papp B., Chen C.-K., McKee R., Wang X.J., Chau A., Sabri S., Leonhardt H., Zheng S., Guttman M., Black D.L., and Plath K.
Ph.D. (2013-2017)
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m6A RNA methylation promotes XIST-mediated transcriptional repression
Nature
September 2016
Patil D.P., Chen C.-K., Pickering B.F., Chow A., Jackson C., Guttman M., and Jaffrey S.R.
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Phosphorylation of synaptojanin differentially regulates endocytosis of functionally distinct synaptic vesicle pools
The Journal of Neuroscience
August 2016
Geng J., Wang L., Lee J.Y., Chen C.-K., and Chang K.T.
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Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing
Science
August 2016
Chen C.-K., Blanco M., Jackson C., Aznauryan E., Ollikainen N., Surka C., Chow A., McDonel P., Cerase A., and Guttman M.
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The Xist IncRNA interacts directly with SHARP to silence transcription through HDAC3
Nature
April 2015
McHugh C.A., Chen C.-K., Chow A., Surka C.F., Tran C., McDonel P., Pandya-Jones A., Blanco M., Burghard C., and Moradian A.
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Single-cell phenotyping within transparent intact tissue through whole-body clearing
Cell
July 2014
Yang B., Treweek J.B., Kulkarni R.P., Deverman B.E., Chen C.-K., Lubeck E., Shah S., Cai L., and Gradinaru V.
M.S. (2011-2013)
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Activity-dependent facilitation of synaptojanin and synaptic vesicle recycling by the minibrain kinase
Nature Communications
June 2014
Chen C.-K., Bregere C., Paluch J., Lu J.F., Dickman D.K., and Chang K.T.
Patents
Postdoctoral (2017-2022)
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Sequence features modulating circular RNA immunity and translation
US PCT/US2020/047995
Howard Y. Chang, Robert Chen, Laura Amaya, and Chun-Kan Chen.
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Genetic elements driving circular RNA translation and methods of use
US PCT/US2021/039127
Howard Y. Chang, Chun-Kan Chen.
Ph.D. (2013-2017)
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Hdac inhibitor compositions for reactivation of the X chromosome
WO EP US JP, US20200179420A1
M Guttman, CK Chen.