Publications

Postdoctoral (2017-2022)
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Engineering circular RNA for enhanced protein production

Nature Biotechnology
July 2022

Chen R., Wang S.K., Belk J.A., Amaya L., Li Z., Cardenas A., Abe B.T., Chen C.-K., Wender P.A., and Chang H.Y.

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The role of circular RNAs in pulmonary hypertension

European Respiratory Journal
December 2022

Ali M.K., Schimmel K., Zhao L., Chen C.-K., Dua K., Nicolls M.R., and Spierkerkoetter E.

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Noncoding RNAs: Biology and applications – A Keystone Symposia report

Annals of the New York Academy of Science
December 2021

Cable J., Heard E., Hirose T., Prasanth K.V., Chen L.L., Henninger J.E., Quinodoz S.A., Spector D.L., Diermeier S.D., Porman A.M., Kumar D., Feinberg M.W., Shen X., Unfried J.P., Johnson R., Chen C.-K., Wilusz J.E., Lempradl A., McGeary S.E., Wahba L., Pyle A.M., Hargrove A.E., Simon M.D., Marcia M., Przanowska R.K., Chang H.Y., Jaffrey S.R., Contreras L.M., Chen Q., Shi J., Mendell J.T., He L., Song E., Rinn J.L., Lalwani M.K., Kalem M.C., Chuong E.B., Maquat L.E., and Liu X.

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Structured elements drive extensive circular RNA translation

Molecular Cell
October 2021

Chen C.-K., Cheng R., Demeter J., Chen J., Weingarten-Gabbay S., Jiang L., Snyder M.P., Weissman J.S., Segal E., Jackson P.K., and Chang H.Y.

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A protein assembly mediates Xist localization and gene silencing

Nature
September 2020

Pandya-Jones A., Markaki Y., Serizay J., Chitiashvili T., Leon W.R.M., Damianov A., Chronis C., Papp B., Chen C.-K., McKee R., Wang X.J., Chau A., Sabri S., Leonhardt H., Zheng S., Guttman M., Black D.L., and Plath K.

Ph.D. (2013-2017)
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m6A RNA methylation promotes XIST-mediated transcriptional repression

Nature
September 2016

Patil D.P., Chen C.-K., Pickering B.F., Chow A., Jackson C., Guttman M., and Jaffrey S.R.

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Phosphorylation of synaptojanin differentially regulates endocytosis of functionally distinct synaptic vesicle pools

The Journal of Neuroscience
August 2016

Geng J., Wang L., Lee J.Y., Chen C.-K., and Chang K.T.

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Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

Science
August 2016

Chen C.-K., Blanco M., Jackson C., Aznauryan E., Ollikainen N., Surka C., Chow A., McDonel P., Cerase A., and Guttman M.

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The Xist IncRNA interacts directly with SHARP to silence transcription through HDAC3

Nature
April 2015

McHugh C.A., Chen C.-K., Chow A., Surka C.F., Tran C., McDonel P., Pandya-Jones A., Blanco M., Burghard C., and Moradian A.

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Single-cell phenotyping within transparent intact tissue through whole-body clearing

Cell
July 2014

Yang B., Treweek J.B., Kulkarni R.P., Deverman B.E., Chen C.-K., Lubeck E., Shah S., Cai L., and Gradinaru V.

M.S. (2011-2013)
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Activity-dependent facilitation of synaptojanin and synaptic vesicle recycling by the minibrain kinase

Nature Communications
June 2014

Chen C.-K., Bregere C., Paluch J., Lu J.F., Dickman D.K., and Chang K.T.

Patents

Postdoctoral (2017-2022)
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Sequence features modulating circular RNA immunity and translation

US PCT/US2020/047995

Howard Y. Chang, Robert Chen, Laura Amaya, and Chun-Kan Chen.

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Genetic elements driving circular RNA translation and methods of use

US PCT/US2021/039127

Howard Y. Chang, Chun-Kan Chen.

Ph.D. (2013-2017)
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Hdac inhibitor compositions for reactivation of the X chromosome

WO EP US JP, US20200179420A1

M Guttman, CK Chen.

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Reactivation of X chromosome genes

WO EP US, US20160313304A1

M Guttman, CK Chen, CA McHugh.