We utilize multi-omic and high-throughput screening approaches to investigate the regulation and function of circRNA and uncover the molecular mechanisms of circRNA-mediated disease.

We aim to uncover (i) the RNA elements, genomic features, and protein components
regulating the functions of circRNAs, (ii) the molecular mechanism of how circRNAs regulate cell physiology, and (iii) how circRNA dysregulation can lead to disease pathogenesis. Our long-term goal is to harness the unique properties of circRNAs to develop new tools for RNA-based technologies and therapeutic interventions.

Select Publications

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Engineering circular RNA for enhanced protein production

Nature Biotechnology
July 2022

Chen R., Wang S.K., Belk J.A., Amaya L., Li Z., Cardenas A., Abe B.T., Chen C.-K., Wender P.A., and Chang H.Y.

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Structured elemens drive extensive circular RNA translation

Molecular Cell
October 2021

Chen C.-K., Cheng R., Demeter J., Chen J., Weingarten-Gabbay S., Jiang L., Snyder M.P., Weissman J.S., Segal E., Jackson P.K., and Chang H.Y.

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Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing

August 2016

Chen C.-K., Blanco M., Jackson C., Aznauryan E., Ollikainen N., Surka C., Chow A., Cerase A., McDonel P., and Guttman M.

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m(6)A RNA methylation promotes XIST-mediated transcriptional repression

September 2016

Patil D.P., Chen C.-K., Pickering B.F., Chow A., Jackson C., Guttman M., and Jaffrey S.R.

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The Xist IncRNA interacts directly with SHARP to silence transcription through HDAC3

April 2015

McHugh C.A.*, Chen C.-K.*, Chow A., Surka C.F., Tran C., McDonel O., Pandya-Jones A., Blanco M., Burghard C., Moradian A., Sweredoski M.J., Shishkin A.A., Su J., Lander E.S., Hess S., Plath K., and Guttman M. *Co-first authors

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The Chen Lab is always looking for new team members. Learn more about our lab and how to join!