-First structure of a CLCA protein; modulator of the TMEM16A calcium-activated chloride channel; 6PYO and 6PYX
YbtT
-Structures of E. coli YbtT- Type II thioesterase from the Yerseniabactin NRPS/PKS biosynthetic pathway; drug target for urinary tract infections (UTI); 6BA8 and 6BA9
TREM2
-First crystal structure of TREM2; Emerging drug target for Alzheimer’s disease; 5ELI
MAPK13 in complex with inhibitors and in activated form
-MAPK13 is a drug target for mucus overproduction in asthma and COPD; First structures of MAPK13 in complex with inhibitors; First structure of activated MAPK13; 4YNO, 4MYG, 5EKO, 5EKN, 4EYJ, 4EYM
BST-2/Tetherin Ectodomain
-First full ectodomain structure of the antiviral restriction factor BST-2/tetherin, 3NI0
HIP1R THATCH Domain core
-First structure of the F-actin binding THATCH domain from the clathrin-mediated endocytic adaptor HIP1R, 1R0D
Clathrin Adaptor Protein AP-2 alpha-appendage in complex with accessory protein motifs
-First structure of the clathrin adaptor AP-2 alpha appendage in complex with recruitment motifs from endocytosis accessory proteins (DPF, DPW, and FxDxF); 1KY6, 1KY7, 1KYD, 1KYF, 1KYU
