2024
McMillan, OL, Liang, L, Su, G, Song, X, Drago, K, Yang, H, Alvarez, C, Sood, A, Gibson, J, Woods, RJ, Wang, C, Liu, J, Zhang, F, Brett, TJ, Wang, L. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. Journal of Biological Chemistry, Aug (2024). JBC
Sala-Rabanal, M, Yurtsever, Z, Berry, KN, McClenaghan, C, Foy, AJ, Hanson, A, Steinberg, DF, Greven, JA, Kluender, CE, Alexander-Brett, JM, Nichols, CG, Brett, TJ. Modulation of TMEM16B Channel Activity by the Calcium-Activated Chloride Channel Regulator 4 (CLCA4) in Human Cells. Journal of Biological Chemistry, 300 (7) 107432, May (2024). JBC
Dean, HS, Greer, RA, Yang, S-Z, Elston, DS, Brett, TJ, Roberson, ED, Song, Y. Multimerization of TREM2 is impaired by Alzheimer’s disease-associated variants. Alzheimer’s and Dementia, July (2024). Alzheimer’s and Dementia
2022
Greven, JA, Brett, TJ. Production of Eukaryotic Glycoproteins for Structural and Functional Studies using Expi293F Cells. Current Protocols, 2 (8), Aug (2022).
2021
Ganaie, SS ,Schwarz, MM, McMillen, CM, Price, DA, Feng, AX, Albe, JR, Wang, W, Miersch, S, Overdahl, A, Cole, AR, Sentmanat, MF, Mishra, N, Boyles, DA, Koenig, ZT, Kujawa, MR, Demers, MA, Hoehl, RM, Moyle, AB, Wagner, ND, Stubbs, SH, Cardarelli, L, Teyra, J, McElroy, A, Gross, ML, Whelan, SPJ, Doench, J, Cui, X, Brett, TJ, Sidhu, SS, Virgin, HW, Egawa, T, Leung DW, Amarasinghe, GK, Hartman, AL. Lrp1 is a host entry factor for Rift Valley fever virus. Cell, 184, 5613-5178, (2021). Cell
2020
Kober, DL,Stuchell-Brereton, MD, Kluender, CE, Dean, HB, Strickland, MR, Steinberg, DF, Nelson, SS, Baban, B, Holtzman, DM, Frieden, C, Alexander-Brett, J, Roberson, ED, Song, Y, Brett, TJ. Functional insights from biophysical study of TREM2 interactions with ApoE and Abeta1-42. Alzheimer’s and Dementia , online Oct 8 , (2020). Alzheimer’s and Dementia
Berry, KN, Brett, TJ. Structural and Biophysical Analysis of the CLCA1 VWA Domain suggests Mode of TMEM16A Engagement. Cell Reports, 30, 4 1141-1151, (2020). Cell Reports
2019
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C, Brett, TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk.. Sci Transl Med, epub August 14, (2019). STM
2018
Ohlemacher, SI, Xu, Y, Kober, DL, Malik, M, Nix, JC, Brett, TJ, Henderson, JP. YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria. J Biol Chem, epub Oct 24, (2018). JBC
Berry, KN, Kober, DL, Su, A, Brett, TJ. Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-/Tetherin: Knowledge and Gaps. BioEssays, 40, 1-9, (2018). BioEssays
2017
Sala-Rabanal, M, Yurtsever, Z, Berry, KN, Nichols, CG, Brett, TJ. Modulation of TMEM16A Channel Activity by the Von Willebrand Factor Type A (VWA) domain of the Calcium-Activated Chloride Channel Regulator 1 (CLCA1). Journal of Biological Chemistry, 292: 9164-9174, (2017). JBC
Kober DL, Brett, TJ. TREM2-ligand interactions in health and disease. Journal of Molecular Biology , 429, 1607-1629 (2017). JMB
2016
Kober DL, Alexander-Brett, JM, Karch, CM, Cruchaga, C, Colonna, M, Holtzman, MJ, Brett, TJ. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. eLife, Dec 20 , (2016). Pubmed
Yurtsever, Z, Patel, DA, Kober DL, Su, A, Romero, AG, Holtzman, MJ, Brett, TJ. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochimica et Biophysica Acta- General Subjects, 1860: 2335-2344 , (2016). Pubmed
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D’Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nature Communications, Mar 7, 10882, (2016). Pubmed
2015
Kober, DL, Yurtsever, Z, Brett, TJ. Efficient mammalian cell expression and single-step purification of extracellular glycoproteins for crystallization. Journal of Visualized Experiments, 106, 53445, (2015). Pubmed
Sala-Rabanal, M, Yurtsever, Z, Berry, KN, Brett, TJ. Novel roles for chloride channels, exchangers, and regulators in chronic inflammatory airway diseases. Mediators of Inflammation, Nov 9, 497387, 1-13 (2015). Pubmed
Zhang, Y, Mao, D, Roswit, WT, Jin, X, Patel, AC, Patel, DA, Agapov, E, Wang, Z, Tidwell, RM, Atkinson, JJ, Huang, G, McCarthy, R, Yu, J, Yun, NE, Paessler, S, Lawson, TG, Omattage, NS, Brett, TJ, Holtzman, MJ. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection. Nature Immunology, 16 , 1215-1227 (2015). PubMed
Brett, TJ. CLCA1 and TMEM16A: the link towards a potential cure for airway diseases. Expert Reviews in Respiratory Medicine, 9 , 503-6 (2015). PubMed
Wu, K, Beyers, DE, Jin, X, Agapov, E, Alexander-Brett, JM, Patel, AC, Cella, M, Gilfillan, S, Colonna, M, Kober, DL, Brett, TJ, Holtzman, MJ. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection. Journal of Experimental Medicine, 212, 681-97 (2015). PubMed
Yurtsever, Z, Scheaffer, SM, Romero, AG, Holtzman, MJ, Brett, TJ. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation. Acta Crystallographica D, Biological Crystallography, D71, 790-9 (2015). PubMed
Sala-Rabanal, M, Yurtsever, Z, Nichols, CG, Brett, TJ. Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells. eLife, 4, 1-14 (2015). PubMed
2014
Kober, DL, Wanhainen, KM, Johnson, BM, Randolph, DT, Holtzman, MJ, Brett, TJ. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases. Protein Expression and Purification, 96, 32-8 (2014). PubMed
Xu, W, Edwards, MR, Borek, DM, Feagins, AR, Mittal, A., Alinger, JB, Berry, KN, Yen, B, Hamilton, J, Brett, TJ, Pappu, RV, Leung, DW, Basler, CF, Amarasinghe, GK. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. Cell Host and Microbe, 16, 187-200 (2014). PubMed
2013
Combs, MD, Knutsen, RH, Broekelmann, TJ, Toennies, HM, Brett, TJ, Miller, CA, Kober, DL, Craft, CS, Atkinson, JJ, Shipley, JM, Trask, BC, Mecham, RP. Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. Journal of Biological Chemistry, 288, 28869-80 (2013). PubMed
Swiecki, M., Omattage, N.S., and Brett, T.J., BST-2/tetherin: Structural biology, viral antagonism, and immunobiology of a potent host antiviral factor. Molecular Immunology, 54, 132-9 (2013). PubMed
2012
Alevy, Y.G., Patel, A.C., Romero, A.G., Patel, D.A., Tucker J., Roswit, W.T., Miller, C.A., Heier, R.F., Byers, D.E., Brett, T.J., and Holtzman, M.J., IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. Journal of Clinical Investigation, 122, 4555-4568 (2012). PubMed
Yurtsever, Z., Sala-Rabanal, M., Randolph, D.T., Scheaffer, S.M., Roswit, W.T., Alevy, Y.G., Patel, A.C., Heier, R.F., Romero, A.G., Nichols, C.G., Holtzman, M.J., and Brett, T.J., Self-cleavage of human CLCA1 by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. Journal of Biological Chemistry, 287, 42138-49 (2012). Article of the Week. PubMed
Doray, B., Misra, S., Qian, Y., Brett, T.J., and Kornfeld, S., Do GGA adaptors bind internal DXXLL motifs? Traffic, 13, 1315-1325 (2012). PubMed
2011
Swiecki, M., Scheaffer, S.M., Allaire, M., Fremont, D.H., Colonna, M., and Brett, T.J., Structural and biophysical analysis of BST-2/tetherin ectodomains reveal an evolutionary conserved design to inhibit virus release. Journal of Biological Chemistry, 286, 2987-2997 (2011). PubMed
Akhtar, K., Broekelmann, T.J., Song, H., Turk, J., Brett, T.J., Mecham, R.P., and Adair-Kirk, T.I., Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding. Journal of Biological Chemistry, 286, 13574-13582 (2011). PubMed
2009
Patel, A.C., Brett, T.J., and Holtzman, M.J., The role of CLCA proteins in inflammatory airway disease. Annual Review of Physiology, 71, 425-449 (2009). PubMed
2006
Brett, T.J. and Traub, L.M., Molecular structures of coat and coat-associated proteins: function follows form. Current Opinion in Cell Biology, 18, 395-406 (2006). PubMed
Brett, T.J., Legendre-Guillemin, V., McPherson, P.S., and Fremont, D. H., Structural definition of the F-actin-binding THATCH domain from HIP1R. Nature Structural & Molecular Biology, 13, 121-130 (2006). PubMed
2004
Ota, N., Brett, T.J., Murphy, T.L., Fremont, D.H., and Murphy, K.M., N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nature Immunology, 5, 208-215 (2004). PubMed
Mishra, S.K.*, Hawryluk, M.J.*, Brett, T.J.*, Keyel, P.K., Dupin, A.L., Jha, A., Heuser, J.E., Fremont, D.H., and Traub, L.M., Dual engagement regulation of protein interactions with the AP-2 adaptor a-appendage**. Journal of Biological Chemistry, 279, 46191-46203 (2004).
*- co-first authors **- cover article PubMed
2002
Brett, T.J., Traub, L.M., and Fremont, D.H., Accessory protein recruitment motifs in clathrin-mediated endocytosis**. Structure (Camb), 10, 797-809 (2002).
**- cover article PubMed
Alexander, J.M., Nelson, C.A., van Berkel, V., Lau, E.K., Studts, J.M., Brett, T.J., Speck, S.H., Handel, T.M., Virgin, H.W., and Fremont, D.H., Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell, 111, 343-356 (2002). PubMed
Alexander, J.M., Clark, J.L., Brett, T.J., and Stezowski J.J., Chiral discrimination in cyclodextrin complexes of amino acid derivatives: b-cyclodextrin/N-acetyl-L-phenylalanine and N-acetyl-D-phenylalanine complexes. Proceedings of the National Academy of Sciences of the U.S.A., 99, 5115-5120 (2002). PubMed
2001
Mishra, S.K., Agostinelli, N.R., Brett, T.J., Mizukami, I., Ross, T.S., and Traub, L.M., Clathrin- and AP-2-binding sites in HIP1 uncover a general role for endocytic accessory proteins. Journal of Biological Chemistry, 276, 46230-46236 (2001). PubMed
Rajca, A., Wang, H., Pawitranon, V., Brett, T.J., and Stezowski, J.J., Synthesis and structure of tetrathiophene with a chiral 1,1’-binaphthyl kink. Chemical Communications, 1060-1061 (2001).
2000
Clark, K. A., George, T. A., Brett, T. J., Ross, C. R., & Shoemaker, R. K. (2000). Synthesis, characterization, crystal structures, and reactions of trigonal bipyramidal tin(iv) complexes containing a tetradentate tripodal Tristhiolatophosphine ligand. use in the one-step synthesis of an iron(iv) complex. Inorganic Chemistry, 39(11), 2252–2253. https://doi.org/10.1021/ic991371n
Brett, T. J., & Stezowski, J. J. (2000). Structural studies of supramolecular β-cyclodextrin complexes with butyrophenone and valerophenone: An explanation for photochemical reaction modification. Chemical Communications, (10), 857–858. https://doi.org/10.1039/b002828m
Brett, T. J., Alexander, J. M., & Stezowski, J. J. (2000b). Chemical Insight from crystallographic disorder-structural studies of supramolecular photochemical systems. part 3. the β-cyclodextrin–7-hydroxy-4-methylcoumarin inclusion complex: Direct observation of photodimerization by X-ray crystallography. Journal of the Chemical Society, Perkin Transactions 2, (6), 1105–1111. https://doi.org/10.1039/a906042a
Brett, T. J., Alexander, J. M., & Stezowski, J. J. (2000a). Chemical Insight from crystallographic disorder-structural studies of supramolecular photochemical systems. part 2. the β-cyclodextrin–4,7-dimethylcoumarin inclusion complex: A new β-cyclodextrin dimer packing type, unanticipated photoproduct formation, and an examination of guest influence on β-CD dimer packing. Journal of the Chemical Society, Perkin Transactions 2, (6), 1095–1103. https://doi.org/10.1039/a906041c
1999
Brett, T. J., Stezowski, J. J., Liu, S., & Coppens, P. (1999). The 20 K structure of P-amino-p′-nitrobiphenyl in the non-constraining environment of its β-cyclodextrin inclusion complex. Chemical Communications, (6), 551–552.
Brett, T. J., Alexander, J. M., Clark, J. L., Ross II, C. R., Harbison, G. S., & Stezowski, J. J. (1999). Chemical Insight from Crystallographic disorder: Structural studies of a supramolecular β-cyclodextrin/coumarin photochemical system. Chemical Communications, (14), 1275–1276.
1994
Guan, H. W., Pauley, M. A., Brett, T. J., Wang, C. H. (1994). Investigation of dipolar reorientation dynamics of pure bulk polymers using second harmonic generation. Journal of Polymer Science Part B: Polymer Physics, 32(16), 2615–2624.