2020

Berry, KN, Brett, TJ. Structural and Biophysical Analysis of the CLCA1 VWA Domain suggests Mode of TMEM16A Engagement.  Cell Reports, 30, 4 1141-1151, (2020). Cell Reports

2019

Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, Zetterberg H, Heslegrave A, Johansson PM, Svensson J, Nellgård B, Lleo A, Alcolea D, Clarimon J, Rami L, Molinuevo JL, Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Ewers M, Harari O, Haass C,  Brett, TJ, Benitez BA, Karch CM, Piccio L, Cruchaga C. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk..  Sci Transl Med, epub August 14, (2019). STM

2018

Ohlemacher, SI, Xu, Y, Kober, DL, Malik, M, Nix, JC, Brett, TJ, Henderson, JP. YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.  J Biol Chem, epub Oct 24, (2018). JBC

Berry, KN, Kober, DL, Su, A, Brett, TJ. Limiting Respiratory Viral Infection by Targeting Antiviral and Immunological Functions of BST-/Tetherin: Knowledge and Gaps.  BioEssays, 40, 1-9, (2018). BioEssays

2017

Sala-Rabanal, M, Yurtsever, Z, Berry, KN, Nichols, CG, Brett, TJ. Modulation of TMEM16A Channel Activity by the Von Willebrand Factor Type A (VWA) domain of the Calcium-Activated Chloride Channel Regulator 1 (CLCA1).  Journal of Biological Chemistry, 292: 9164-9174, (2017).   JBC

Kober DL, Brett, TJ. TREM2-ligand interactions in health and disease.  Journal of Molecular Biology , 429, 1607-1629 (2017).   JMB

2016

Kober DL, Alexander-Brett, JM, Karch, CM, Cruchaga, C, Colonna, M, Holtzman, MJ, Brett, TJ. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.  eLife, Dec 20 , (2016).   Pubmed

Yurtsever, Z, Patel, DA, Kober DL, Su, A, Romero, AG, Holtzman, MJ, Brett, TJ. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.  Biochimica et Biophysica Acta- General Subjects, 1860: 2335-2344 , (2016).   Pubmed

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D’Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis.  Nature Communications, Mar 7, 10882, (2016).   Pubmed

2015

Kober, DL, Yurtsever, Z, Brett, TJ. Efficient mammalian cell expression and single-step purification of extracellular glycoproteins for crystallization.  Journal of Visualized Experiments, 106, 53445, (2015).   Pubmed

Sala-Rabanal, M, Yurtsever, Z, Berry, KN, Brett, TJ. Novel roles for chloride channels, exchangers, and regulators in chronic inflammatory airway diseases.  Mediators of Inflammation, Nov 9, 497387, 1-13 (2015).   Pubmed

Zhang, Y, Mao, D, Roswit, WT, Jin, X, Patel, AC, Patel, DA, Agapov, E, Wang, Z, Tidwell, RM, Atkinson, JJ, Huang, G, McCarthy, R, Yu, J, Yun, NE, Paessler, S, Lawson, TG, Omattage, NS, Brett, TJ, Holtzman, MJ. PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.  Nature Immunology, 16 , 1215-1227 (2015).   PubMed

Brett, TJ. CLCA1 and TMEM16A: the link towards a potential cure for airway diseases.  Expert Reviews in Respiratory Medicine, 9 , 503-6 (2015).   PubMed

Wu, K, Beyers, DE, Jin, X, Agapov, E, Alexander-Brett, JM, Patel, AC, Cella, M, Gilfillan, S, Colonna, M, Kober, DL, Brett, TJ, Holtzman, MJ. TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.  Journal of Experimental Medicine, 212, 681-97 (2015).   PubMed

Yurtsever, Z, Scheaffer, SM, Romero, AG, Holtzman, MJ, Brett, TJ. The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.  Acta Crystallographica D, Biological Crystallography, D71, 790-9 (2015).   PubMed

Sala-Rabanal, M, Yurtsever, Z, Nichols, CG, Brett, TJ. Secreted CLCA1 modulates TMEM16A to activate Ca2+-dependent chloride currents in human cells.  eLife, 4, 1-14 (2015).   PubMed

2014

Kober, DL, Wanhainen, KM, Johnson, BM, Randolph, DT, Holtzman, MJ, Brett, TJ. Preparation, crystallization, and preliminary crystallographic analysis of wild-type and mutant human TREM-2 ectodomains linked to neurodegenerative and inflammatory diseases.  Protein Expression and Purification, 96, 32-8 (2014).   PubMed

Xu, W, Edwards, MR, Borek, DM, Feagins, AR, Mittal, A., Alinger, JB, Berry, KN, Yen, B, Hamilton, J, Brett, TJ, Pappu, RV, Leung, DW, Basler, CF, Amarasinghe, GK. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.  Cell Host and Microbe, 16, 187-200 (2014).   PubMed

2013

Combs, MD, Knutsen, RH, Broekelmann, TJ, Toennies, HM, Brett, TJ, Miller, CA, Kober, DL, Craft, CS, Atkinson, JJ, Shipley, JM, Trask, BC, Mecham, RP. Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.  Journal of Biological Chemistry, 288, 28869-80 (2013).   PubMed

Swiecki, M., Omattage, N.S., and Brett, T.J., BST-2/tetherin: Structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.  Molecular Immunology, 54, 132-9 (2013).   PubMed

2012

Alevy, Y.G., Patel, A.C., Romero, A.G., Patel, D.A., Tucker J., Roswit, W.T., Miller, C.A., Heier, R.F., Byers, D.E., Brett, T.J., and Holtzman, M.J., IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.  Journal of Clinical Investigation, 122, 4555-4568 (2012).   PubMed

Yurtsever, Z., Sala-Rabanal, M., Randolph, D.T., Scheaffer, S.M., Roswit, W.T., Alevy, Y.G., Patel, A.C., Heier, R.F., Romero, A.G., Nichols, C.G., Holtzman, M.J., and Brett, T.J., Self-cleavage of human CLCA1 by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.  Journal of Biological Chemistry, 287, 42138-49 (2012). Article of the Week.   PubMed

Doray, B., Misra, S., Qian, Y., Brett, T.J., and Kornfeld, S., Do GGA adaptors bind internal DXXLL motifs?  Traffic, 13, 1315-1325 (2012).   PubMed

2011

Swiecki, M., Scheaffer, S.M., Allaire, M., Fremont, D.H., Colonna, M., and Brett, T.J., Structural and biophysical analysis of BST-2/tetherin ectodomains reveal an evolutionary conserved design to inhibit virus release.  Journal of Biological Chemistry, 286, 2987-2997 (2011).   PubMed

Akhtar, K., Broekelmann, T.J., Song, H., Turk, J., Brett, T.J., Mecham, R.P., and Adair-Kirk, T.I., Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding.  Journal of Biological Chemistry, 286, 13574-13582 (2011).   PubMed

2009

Patel, A.C., Brett, T.J., and Holtzman, M.J., The role of CLCA proteins in inflammatory airway disease Annual Review of Physiology, 71, 425-449 (2009).   PubMed

2006

Brett, T.J. and Traub, L.M., Molecular structures of coat and coat-associated proteins: function follows form Current Opinion in Cell Biology, 18, 395-406 (2006).   PubMed

Brett, T.J., Legendre-Guillemin, V., McPherson, P.S., and Fremont, D. H., Structural definition of the F-actin-binding THATCH domain from HIP1R Nature Structural & Molecular Biology, 13, 121-130 (2006).   PubMed

2004

Ota, N., Brett, T.J., Murphy, T.L., Fremont, D.H., and Murphy, K.M., N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nature Immunology, 5, 208-215 (2004).   PubMed

Mishra, S.K.*, Hawryluk, M.J.*, Brett, T.J.*, Keyel, P.K., Dupin, A.L., Jha, A., Heuser, J.E., Fremont, D.H., and Traub, L.M., Dual engagement regulation of protein interactions with the AP-2 adaptor a-appendage**. Journal of Biological Chemistry, 279, 46191-46203 (2004).
*- co-first authors   **- cover article   PubMed

2002

Brett, T.J., Traub, L.M., and Fremont, D.H., Accessory protein recruitment motifs in clathrin-mediated endocytosis**. Structure (Camb), 10, 797-809 (2002).
**- cover article   PubMed

Alexander, J.M., Nelson, C.A., van Berkel, V., Lau, E.K., Studts, J.M., Brett, T.J., Speck, S.H., Handel, T.M., Virgin, H.W., and Fremont, D.H., Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell, 111, 343-356 (2002).   PubMed

Alexander, J.M., Clark, J.L., Brett, T.J., and Stezowski J.J., Chiral discrimination in cyclodextrin complexes of amino acid derivatives: b-cyclodextrin/N-acetyl-L-phenylalanine and N-acetyl-D-phenylalanine complexesProceedings of the National Academy of Sciences of the U.S.A.99, 5115-5120 (2002).   PubMed

2001

Mishra, S.K., Agostinelli, N.R., Brett, T.J., Mizukami, I., Ross, T.S., and Traub, L.M., Clathrin- and AP-2-binding sites in HIP1 uncover a general role for endocytic accessory proteins. Journal of Biological Chemistry,  276, 46230-46236 (2001).   PubMed

Rajca, A., Wang, H., Pawitranon, V., Brett, T.J., and Stezowski, J.J., Synthesis and structure of tetrathiophene with a chiral 1,1’-binaphthyl kink. Chemical Communications, 1060-1061 (2001).

2000

Brett, T.J., Alexander, J.M., Stezowski, J.J., Chemical insight from crystallographic disorder- structural studies of supramolecular photochemical systems.  Part 3.  The b-cyclodextrin/7-hydroxy-4-methylcoumarin inclusion complex: Direct observation of photodimerization by X-ray crystallography. Journal of the Chemical Society, Perkin Transactions II, 1105-1111 (2000).

Brett, T.J., Alexander, J.M., Stezowski, J.J., Chemical insight from crystallographic disorder- structural studies of supramolecular photochemical systems.  Part 2.  The b-cyclodextrin/4,7-dimethylcoumarin inclusion complex: A new b-cyclodextrin dimer packing type, unanticipated photoproduct formation, and an examination of guest influence on b-CD dimer packing. Journal of the Chemical Society, Perkin Transactions II, 1095-1103 (2000).

Clark, K.A., George, T.A., Brett, T.J., Ross,II, C.R., Shoemaker, R.K., Synthesis, characterization, crystal structures, and reactions of trigonal bipyramidal tin(IV) complexes containing a tetradentate tripodal tristhiolatophosphine ligand. Use in one-step synthesis of an iron(IV) complex. Inorganic Chemistry, 39, 2252-2253 (2000).   PubMed

Brett, T.J., Stezowski, J.J., Structural studies of supramolecular b-cyclodextrin complexes with butyrophenone and valerophenone:  An explanation for photochemical reaction modification. Chemical Communications, 857-858 (2000).

1999

Brett, T.J., Alexander, J.M., Clark, J.L., Ross,II, C.R., Harbison, G.S., Stezowski, J.J., Chemical insight from crystallographic disorder: Structural studies of a supramolecular b-cyclodextrin/coumarin photochemical system. Chemical Communications, 1275-1276 (1999).

Brett, T.J., Liu, S., Coppens, P., Stezowski, J.J., The 20K structure of p-amino-p’-nitrobiphenyl in the non-constraining environment of its b-cyclodextrin inclusion complex. Chemical Communications, 551-552 (1999).