Feature Publications

2024


Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension. Liu B, Yi D, Li S, Ramirez K, Xia X, Cao Y, Zhao H, Tripathi A, Qiu S, Kala M, Rafikov R, Gu H, de Jesus Perez V, Lemay SE, Glembotski CC, Knox KS, Bonnet S, Kalinichenko VV, Zhao YY, Fallon MB, Boucherat O, Dai Z. BioRxiv [Preprint]. 2024 Apr 15:2024.02.11.579846. https://www.biorxiv.org/content/10.1101/2024.02.11.579846v2

Guarding the Endothelium: SOX17’s Crucial Role in Pulmonary Hypertension. Zhang X, Dai Z. American Journal of Respiratory Cell and Molecular Biology. 2024. In press. PMID: 39471328

Protocol for Xenium spatial transcriptomics studies using fixed frozen mouse brain sections. Ma X, Chen P, Wei J, Zhang J, Chen C, Zhao H, Ferguson D, McGee A, Dai Z*, Qiu S*. STAR Protocols. 2024 Nov 12;5(4):103420. (*Co-corresponding author) PMID: 39535916

Unraveling the Role of HIF and Epigenetic regulation in Pulmonary Arterial Hypertension: Implications for Clinical Research and its Therapeutic Approach. Mitra A, Yi D, Dai Z* and De Jesus Perez V*. Frontiers in Medicine. 2024. In press. (*Co-corresponding author). PMID: 39450110

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2a/Notch4 Pathway. Liu B, Yi D, Xia X, Ramirez K, Zhao H, Cao Y, Dong R, Gao A, Ding H, Qiu S, Kalinichenko VV, Fallon MB, Dai Z. Circulation. 2024. 2024 Jul 30;150(5):414-417. PMID: 39074180

The Unexpected Role of GCN2 Kinase Activation in Mediating Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension. Zhu MM, Dai J, Dai Z, Peng Y, Zhao YY. JCI Insight. 2024. In press. PMID: 39316438 

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits. Cui Y, Ma X, Wei J, Chen C, Shakir N, Guirram H, Dai Z, Anderson T, Ferguson D, Qiu S. Neural Regen Res. 2025 May 1;20(5):1431-1444. PMID: 39075910.

AI-Driven Deep Learning Techniques in Protein Structure Prediction. Chen L, Li Q, Nasif KFA, Xie Y, Deng B, Niu S, Pouriyeh S, Dai Z, Chen J, Xie CY.  International Journal of Molecular Sciences. 2024; 25(15):8426.

A Comparative Analysis of SARS-CoV-2 Variants of Concern (VOC) Spike Proteins Interacting with hACE2 Enzyme.  Chen J, Chen L, Quan H, Lee S, Khan KF, Xie Y, Li Q, Valero M, Dai Z, Xie Y. International Journal of Molecular Sciences. 2024; 25(15):8032.

A Novel Animal Model for Pulmonary Hypertension: Lung Endothelial Specific Deletion of Egln1 in Mice
Liu B, Yi D, Ma X, Ramirez K, Xia X, Zhao H, Fallon MB, Kalinichenko VV, Qiu S, Dai Z.  Journal of Respiratory Biology and Translational Medicine. 2024,1(2),10007. PMID: 38974505

Translational Potential 5 of Hypoxia-Inducible Factor-2α Signaling in Pulmonary Hypertension
Dai Z. Lung Biology and Pathophysiology [Book]. Chapter 5. 2024. DOI: 10.1201/9781003355243-6

2023


New Way to Study Pulmonary Hypertension in HFpEF. Dai Z, Thorp EB. Circ Res​. 2023 Nov 10;133(11):899-901. PMID: 37943948

E2F1 mediates SOX17 Deficiency Induces Pulmonary Hypertension. Yi D, Liu B, Ding H, Li S, Li R, Pan J, Ramirez K, Xia X, Kala M, Singh I, Ye Q, Lee WH, Frye R, Wang T, Zhao Y, Knox KS, Glembotski C, Fallon MB, Dai Z. Hypertension. 2023 Nov;80(11):2357-2371. PMID: 37737027.

The Role of a Lung Vascular Endothelium Enriched Gene TMEM100. Jiakai Pan, Bin Liu, Zhiyu Dai. Biomedicines. 2023.11(3), 937. PMID: 36979916

2022


Fatty Acid Metabolism in Endothelial Cell. Liu B, Dai Z. Genes. 2022 Dec 6;13(12):2301. PMID: 36553568
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TMEM100, a Lung-Specific Endothelium Gene. Liu B, Yi D, Yu Z, Pan J, Ramirez K, Li S, Wang T, Glembotski CC, Fallon MB, Oh SP, Gu M, Kalucka J, Dai Z. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022 Oct. PMID: 36252125.

Endothelial PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Hypertension. Liu B, Yi D, Dai J, Peng Y, Vanderpool R, Zhu MM, Dai Z.* & Zhao YY*. (*Co-corresponding author). Eur Respir J. 2022 June. PMID:35798360

Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial Hypertension. Liu B, Yi, D, Pan JK, Dai J, Zhu MM, Zhao YY, Oh SP, Fallon MB, Dai Z. Pulmonary Circulation. 2022;12:e12056. PMID: 35506101

2021


Loss of Endothelial HIF-Prolyl hydroxylase 2 (PHD2) Induces Cardiac Hypertrophy and Fibrosis. Dai Z*, Cheng J, Liu B, Yi D, Feng A, Wang T, Gao C, Wang Y, Zhu MM, Zhang X, Zhao YY*. J Am Heart Assoc.2021. Nov 16;10(22):e022077. (*Co-corresponding author). PMID: 34743552

Endothelial Cells in the Pathogenesis of Pulmonary Arterial Hypertension. Evans CE, Cober ND, Dai Z, Stewart DJ, Zhao YY. Eur Respir J. 2021. Jan. 28;2003957. PMID: 33509961.

Endothelial Autocrine Signaling through CXCL12/CXCR4/FoxM1 Axis Contributes to Severe Pulmonary Arterial Hypertension. Yi D, Liu B, Wang T, Liao Q, Zhu MM, Zhao YY, Dai Z.  Int. J. Mol. Sci. 2021, 22(6), 3182. PMID: 33804745.

before 2020


BET in Pulmonary Arterial Hypertension: Exploration of BET Inhibitors to Reverse Vascular Remodeling
​Dai Z, Zhao YY. Am J Respir Crit Care Med. 2019; 200(7):806-808. PMID: 31112388

Therapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor.
Dai Z, Zhu MM, Peng Y, Machireddy N, Evans CE, Machado R, Zhang X, Zhao YY. Am J Respir Crit Care Med. 2018;198(11):1423-1434. PMID: 29924941

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension. Dai Z, Zhu MM, Peng Y, Machireddy N, Jin H, Zhang X, Zhao YY. Am J Respir Crit Care Med. 2018:198(6):788-802. PMID: 29664678 
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Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α. Dai Z, Li M, Wharton J, Zhu MM, Zhao YY. Circulation. 2016; 133: 2447-2458. PMID: 27143681
This is the first study identifying a novel mouse model (Egln1Tie2Cre mice) with spontaneous severe PAH. Egln1Tie2Cre mice have high eleven right ventricular systolic pressure, right heart failure, severe occlusive vascular remodeling and plexiform-like lesions and progressive mortality.
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Endothelial p110gammaPI3K mediates endothelial regeneration and vascular repair after inflammatory vascular injury. Huang X*, Dai Z*, Cai L, Sun K, Cho J, Albertine KH, Malik AB, Schraufnagel DE, Zhao YY. Circulation. 2016; 133: 1093-1103. (* Equal contribution) PMID: 26839042

Full publications


https://www.ncbi.nlm.nih.gov/myncbi/1rQDlzzGngZka/bibliography/public/