Publications

Dr. Meng Wu’s google scholar profile

SELECTIVE PUBLICATIONS

  1. Wu, M.*, Zheng ,W.*, Song, X., Bao, B., Wang, Y., Ramanan, D., Yang, D., Liu, R., Macbeth, J.C., Do, E.A., et al. (2024) Gut complement induced by the microbiota combats pathogens and spares commensals. Cell 187(4):897-913.e18. doi: 10.1016/j.cell.2023.12.036. 
    • Research Highlights in Nature: Featured in “Surprise find: a blood-based immune system is discovered in the gut.”
    • Spotlight in Immunity: Discussed in “Complement-ary protection for all ages.”
    • Spotlight in Trends in Immunology: Featured in “Complement: you gutsy thing!”
    • Highlighted and cited in Cell review “From Periphery to Center Stage: 50 Years of Advancements in Innate Immunity.”
    • Podcast Feature in “This Week in Microbiology” (TWiM): “The Marvel of MAC.” https://www.microbe.tv/twim/twim-305/
  2. Song, X.*, Zhang, H.*, Zhang, Y., Goh, B., Bao, B., Mello, S.S., Sun, X., Zheng, W., Gazzaniga, F.S., Wu, M., et al. (2023). Gut microbial fatty acid isomerization modulates intraepithelial T cells. Nature 619, 837–843. 10.1038/s41586-023-06265-4.
  3. Park, J.S.*, Gazzaniga, F.S.*, Wu, M., Luthens, A.K., Gillis, J., Zheng, W., LaFleur, M.W., Johnson, S.B., Morad, G., Park, E.M., et al. (2023). Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance. Nature 617, 377–385. 10.1038/s41586-023-06026-3.
  4. Yang, D.*, Jacobson, A.*, Meerschaert, K.A., Sifakis, J.J., Wu, M., Chen, X., Yang, T., Zhou, Y., Anekal, P.V., Rucker, R.A., et al. (2022). Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell 185, 4190-4205.e25. 10.1016/j.cell.2022.09.024.
  5. Gazzaniga, F.S., Camacho, D.M., Wu, M., Silva Palazzo, M.F., Dinis, A.L., Grafton, F.N., Cartwright, M.J., et al. (2021). Harnessing Colon Chip technology to identify commensal bacteria that promote host tolerance to infection. Frontiers in Cellular and Infection Microbiology 11,105.
  6. Wu, M., Kasper, D.L. (2020), Fiber Sets up the Battleground for Intestinal Prevotella. Cell Host & Microbe 28 (6), 776-777
  7. Wu, M.*, Chen, Y.*, Xia, H.*, Wang, C.*, Tan, C.Y.*, Cai, X., Liu, Y., Ji, F., Xiong, P., Liu, R., et al. (2020). Transcriptional and proteomic insights into the host response in fatal COVID-19 cases. Proceedings of the National Academy of Sciences 117, 28336–28343.
  8. Wu, M., Kasper, D.L. (2020), When Lab Mice Go Wild, Fungi Are in Play. Cell Host & Microbe 27 (5), 687-688.
  9. Ramanan D, Sefik E, Galván-Peña S, Wu, M., Yang L, Yang Z, Kostic A, et al. (2020), An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint. Cell 181(6):1276‐1290.
  10. Zheng, W.*, Zhao, W.*, Wu, M., Song, X., Caro, F., Sun, X., Gazzaniga, F., et al. (2020), Commensal microbiota and protective maternal antibodies active in neonates. Nature 577 (7791), 543-548.
  11. Song, X.*, Sun, X.*, Oh, S.F., Wu, M., Zhang, Y., Zheng W., Geva-Zatorsky, N., Jupp, R., et al. (2020), Microbial bile acid metabolites modulate gut RORγ+ Treg cell homeostasis. Nature 577 (7790), 410-415.
  12. Liu, S., Rezende, R.M., Moreira, T.G., Tankou, S.K., Cox L.M., Wu, M., Song, A., Dhang, F.H., et al. (2019), Oral administration of miR-30d from feces of MS patients suppresses MS-like symptoms in mice by expanding Akkermansia muciniphila. Cell Host & Microbe 26 (6), 779-794, e8.
  13. Yang, D., Chen, X., Wang, J., Lou Q., Lou, Y., Li, L., Wang, H., Chen, J., Wu, M., Song, X., Qian, Y. (2019), Dysregulated Lung Commensal Bacteria Drive Interleukin-17B Production to Promote Pulmonary Fibrosis through Their Outer Membrane Vesicles. Immunity 50 (3), 692-706, e7.
  14. Hibberd, M., Wu, M., Rodionov, D.A., Li, X., Cheng, J., Griffin, N. W., Barratt, M. J., et al. (2017) The effects of micronutrient deficiencies on bacterial species from the human gut microbiota. Science Translational Medicine 9(390), eall4069-1-17.
  15. Wu, M., McNulty, N.P., Rodionov, D.A., Khoroshkin, M. S., Griffin, N. W., Cheng, J., Latreille, P., Kerstetter, R.A., et al. (2015) Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides. Science 350(6256): 55, aac5992-1-8.
  16. Chen, S.L.*, Wu, M.*, Henderson, J.P., Hooton, T.M., Hibbing, M.E., et al. (2013). Genomic diversity and fitness of E.coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection. Science Translational Medicine 5(184), 184ra60-184ra60.
  17. Reyes, A., Wu, M., McNulty, N.P., Rohwer, F.L., and Gordon, J.I. (2013). Gnotobiotic mouse model of phage-bacterial host dynamics in the human gut. Proceedings of the National Academy of Sciences 110(50), 20236-20241.
  18. McNulty, N.P., Wu, M., Erickson, A.R., Martens, E.C., Pudlo, N.A., Muegge, B., et al. (2013). Effects of diet on resource utilization by a defined model human gut microbiota containing Bacteroides cellulosilyticus WH2, a symbiont with an extensive glycobiome. PLoS biology 11(8), e1001637.
  19. Rey, F.E., Gonzalez, M., Cheng, J., Wu, M., Ahern, P.P., and Gordon, J.I. (2013). The metabolic niche of a prominent sulfate-reducing human gut bacterium. Proceedings of the National Academy of Sciences 110(33), 13582-13587.
  20. Martens, E.C., Lowe, E., Abbott, W., Chiang, H., Pudlo, N., Wu, M., McNulty, N., Abbott, W., et al. (2011). Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts. PLoS biology 9(12), e1001221.
  21. Goodman, A., Wu, M., and Gordon, J.I. (2011). Identifying microbial fitness determinants by insertion sequencing using genome-wide transposon mutant libraries. Nature Protocols 6(12), 1969-1980.
  22. Hansen, E., Lozupone, C.A., Rey, F.E., Wu, M., Guruge, J.L., Narra, A., Goodfellow, J., et al. (2011). Pan-genome of the dominant human gut-associated archaeon, Methanobrevibacter smithii: studied in twins. Proceedings of the National Academy of Sciences 108(Supplement 1), 4599-4606.
  23. Giannakis, M., Kling Backhed, H., Chen, S.L., Faith, J.J., Wu, M., Guruge J.L., et al. (2009). The response of gastric epithelial progenitors to Helicobacter pylori isolates obtained from Swedish patients with chronic atrophic gastritis. Journal of Biological Chemistry 284(44), 30383-30394.
  24. Saccone N.L., Wang J.C., Breslau N., Johnson E.O., Hatsukami D., Saccone S.F., Grucza R.A., Sun L., Duan W., Budde J., Culverhouse R.C., Fox L., Hinrichs A.L., Steinbach J.H., Wu, M., et al. (2009). The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research 69 (17): 6848-6856.